ANXIETY AND FEAR OF DEATH IN ACUTE CORONARY SYNDROME (ACS)
DOI:
https://doi.org/10.31435/ijitss.1(49).2026.4827Keywords:
Acute Coronary Syndrome, ACS, Anxiety, Fear of DeathAbstract
Research objectives: Anxiety and fear of dying in ACS episodes are recognized as common symptoms that can influence patient outcomes. Etiology of those symptoms remains uncertain, but evidence suggests that the severity of other symptoms and their rapid appearance, combined with the life-threatening nature of ACS, are the main factors.
Methods: This review explores mainly PubMed and Google Scholar databases for studies published between 2000 and 2025. The articles included original research and review papers focusing on the occurrence of anxiety and fear of death symptoms in patients experiencing acute coronary syndrome (ACS), their impact on mortality, severity of anxiety, methods of detecting and finding correlation between those symptoms and types of ACS.
Key findings: Occurrence of Anxiety is high, presented in 32.9% to 56.5% patients. Fear of death occurrence is lower, presented in 21.7% patients. The Cardiac Anxiety Questionnaire (CAQ) is a specialized tool to measure anxiety in ACS. Anxiety during ACS can be divided into three categories: Mild, Moderate, and High/Severe. Anxiety in ACS is associated with 21% greater mortality risk and 47% more major adverse cardiovascular events (MACEs). There is no clear link between anxiety and a specific type of ACS because research results are different and ambiguous.
Conclusion: Anxiety and Fear of death are common but hard to recognize symptoms that occur during ACS. Their presence can cause worse outcomes in some patients. Correct diagnosis and knowledge how to treat fear and anxiety symptoms will improve patient outcomes.
References
Chong, B., Jayabaskaran, J., Jauhari, S. M., Chan, S. P., Goh, R., Kueh, M. T. W., Li, H., Chin, Y. H., Kong, G., Anand, V. V., Wang, J.-W., Muthiah, M., Jain, V., Mehta, A., Lim, S. L., Foo, R., Figtree, G. A., Nicholls, S. J., Mamas, M. A., ... Chan, M. Y. (2025). Global burden of cardiovascular diseases: Projections from 2025 to 2050. European Journal of Preventive Cardiology. https://doi.org/10.1093/eurjpc/zwae281
Salari, N., Morddarvanjoghi, F., Abdolmaleki, A., Rasoulpoor, S., Khaleghi, A. A., Hezarkhani, L. A., Shohaimi, S., & Mohammadi, M. (2023). The global prevalence of myocardial infarction: A systematic review and meta-analysis. BMC Cardiovascular Disorders, 23, Article 206. https://doi.org/10.1186/s12872-023-03231-w
DeVon, H. A., Mirzaei, S., & Zègre-Hemsey, J. (2020). Typical and atypical symptoms of acute coronary syndrome: Time to retire the terms? Journal of the American Heart Association, 9(7), e015539. https://doi.org/10.1161/JAHA.119.015539
Castro Mejía, P. J., Dondero Cassano, P., Díaz Morón, P., Díaz Reátegui, M., Menacho Navarrete, K., & Córdova-Mendoza, P. (2023). Prevalence of anxiety and depression in patients with acute coronary syndrome: Systematic review and meta-analysis. The Pan African Medical Journal, 46, Article 91. https://doi.org/10.11604/pamj.2023.46.91.41792
Perona, M., Cooklin, A., Thorpe, C., O’Meara, P., & Rahman, M. A. (2024). Symptomology, outcomes and risk factors of acute coronary syndrome presentations without cardiac chest pain: A scoping review. European Cardiology Review, 19, e13. https://doi.org/10.15420/ecr.2023.45
Alkhaqani, A. L. (2023). Impact anxiety on quality of life and clinical outcomes of patients with acute coronary syndrome. Figshare. https://doi.org/10.6084/m9.figshare.22266301
Bhatt, D. L., Lopes, R. D., & Harrington, R. A. (2022). Diagnosis and treatment of acute coronary syndromes: A review. JAMA, 327(7), 662–675. https://doi.org/10.1001/jama.2022.0358
Spek, M., Venekamp, R. P., Erkelens, D. C. A., van Smeden, M., Wouters, L. T. C. M., den Ruijter, H. M., Rutten, F. H., & Zwart, D. L. (2023). Shortness of breath as a diagnostic factor for acute coronary syndrome in male and female callers to out-of-hours primary care. Heart. https://doi.org/10.1136/heartjnl-2023-323220
Parodi, G., & Storey, R. F. (2014). Dyspnoea management in acute coronary syndrome patients treated with ticagrelor. European Heart Journal: Acute Cardiovascular Care, 4(6), 555–560. https://doi.org/10.1177/2048872614554108
Boeddinghaus, J., Nestelberger, T., Koechlin, L., Lopez-Ayala, P., Wussler, D., Mais, M., Zwimpfer, L., Zimmermann, T., Wildi, K., Rubini Giménez, M., Strebel, I., Miró, Ò., Martin-Sanchez, F. J., Parenica, J., Keller, D. I., Gualandro, D. M., Nickel, C. H., Bingisser, R., Christ, M., & Mueller, C. (2023). Association of accompanying dyspnoea with diagnosis and outcome of patients presenting with acute chest discomfort. European Heart Journal: Acute Cardiovascular Care, 12(5), 283–295. https://doi.org/10.1093/ehjacc/zuad026
Gokhroo, R. K., Ranwa, B. L., Kishor, K., Priti, K., Ananthraj, A., Gupta, S., & Bisht, D. (2015). Sweating: A specific predictor of ST-segment elevation myocardial infarction among the symptoms of acute coronary syndrome: Sweating in myocardial infarction (SWIMI) Study Group. Clinical Cardiology, 39(1), 17–22. https://doi.org/10.1002/clc.22498
Dobbe, A. S. M., Zwart, D. L., van der Hem, L., Erkelens, D. C., Wouters, L. T. C. M., van Doorn, S., den Ruijter, H. M., & Rutten, F. H. (2025). Are dizziness/lightheadedness helpful symptoms for telephone triage of females and males calling the out-of-hours service for acute chest discomfort? A cross-sectional study. BMJ Open, 15(2), e092368. https://doi.org/10.1136/bmjopen-2024-092368
Leissner, P., Held, C., Humphries, S., Rondung, E., & Olsson, E. M. G. (2024). Association of anxiety and recurrent cardiovascular events: Investigating different aspects of anxiety. European Journal of Cardiovascular Nursing, 23(7), 720–728. https://doi.org/10.1093/eurjcn/zvae036
Marker, C. D., Carmin, C. N., & Ownby, R. L. (2008). Cardiac anxiety in people with and without coronary atherosclerosis. Depression and Anxiety, 25(10), 824–831. https://doi.org/10.1002/da.20348
Leissner, P., Held, C., Rondung, E., & Olsson, E. M. G. (2022). The factor structure of the cardiac anxiety questionnaire, and validation in a post-MI population. BMC Medical Research Methodology, 22, Article 338. https://doi.org/10.1186/s12874-022-01820-5
Whitehead, D. L., Strike, P., Perkins-Porras, L., & Steptoe, A. (2005). Frequency of distress and fear of dying during acute coronary syndromes and consequences for adaptation. The American Journal of Cardiology, 96(11), 1512–1516. https://doi.org/10.1016/j.amjcard.2005.07.070
Birk, J. L., Cumella, R., Lopez-Veneros, D., Jurado, A., Romero, E. K., Lazarov, A., & Kronish, I. M. (2020). Intervening on fear after acute cardiac events: Rationale and design of the INFORM randomized clinical trial. Health Psychology, 39(9), 736–744. https://doi.org/10.1037/hea0000853
Steptoe, A., Molloy, G. J., Messerli-Bürgy, N., Wikman, A., Randall, G., Perkins-Porras, L., & Kaski, J. C. (2011). Fear of dying and inflammation following acute coronary syndrome. European Heart Journal, 32(19), 2405–2411. https://doi.org/10.1093/eurheartj/ehr132
Li, J., Ji, F., Song, J., Gao, X., Jiang, D., Chen, G., Chen, S., Lin, X., & Zhuo, C. (2020). Anxiety and clinical outcomes of patients with acute coronary syndrome: A meta-analysis. BMJ Open, 10(7), e034135. https://doi.org/10.1136/bmjopen-2019-034135
Li, P., Lu, X., Kranis, M., Wu, F., Teng, C., Cai, P., Hashmath, Z., & Wang, B. (2020). The association between anxiety disorders and in-hospital outcomes in patients with myocardial infarction. Clinical Cardiology, 43(6), 622–629. https://doi.org/10.1002/clc.23358
Albarqouni, L., von Eisenhart Rothe, A., Ronel, J., Meinertz, T., & Ladwig, K. H. (2016). Frequency and covariates of fear of death during myocardial infarction and its impact on prehospital delay: Findings from the multicentre MEDEA Study. Clinical Research in Cardiology, 105, 135–144. https://doi.org/10.1007/s00392-015-0895-3
Sławska, A., & Siudak, Z. (2018). Fear of death in acute coronary syndromes—incidence and predictors. Medical Studies/Studia Medyczne, 34(4), 304–308. https://doi.org/10.5114/ms.2018.80946
Rao, S. V., O’Donoghue, M. L., Ruel, M., Rab, T., Tamis-Holland, J. E., Alexander, J. H., & others. (2025). 2025 ACC/AHA/ACEP/NAEMSP/SCAI guideline for the management of patients with acute coronary syndromes. Circulation. https://doi.org/10.1161/CIR.0000000000001309
Eifert, G. H., Thompson, R. N., Zvolensky, M. J., Edwards, K., Frazer, N. L., Haddad, J. W., & Davig, J. (2000). The Cardiac Anxiety Questionnaire: Development and preliminary validity. Behaviour Research and Therapy, 38(10), 1039–1053. https://doi.org/10.1016/S0005-7967(99)00132-1
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Copyright (c) 2026 Kamil Źródłowski, Aleksandra Korżel, Barbara Katarzyna Przybył, Patrycja Anita Kobrzyńska, Natalia Cegielska, Jędrzej Mogilany, Julia Niedźwiecka, Ewelina Wojna, Karolina Górowska, Gabriela Ragan

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