LUNG ULTRASOUND IN THE DIAGNOSIS OF MECONIUM ASPIRATION SYNDROME IN NEONATES: A SYSTEMATIC REVIEW

Authors

DOI:

https://doi.org/10.31435/ijitss.1(49).2026.4972

Keywords:

Meconium Aspiration Syndrome, Lung Ultrasound, Neonate

Abstract

The aim of the study: Meconium aspiration syndrome (MAS) remains an important cause of neonatal respiratory distress and is traditionally diagnosed using clinical criteria supported by chest X-ray. Lung ultrasound (LUS) is a radiation-free, bedside imaging modality increasingly used in neonatal lung diseases. The objective of this systematic review is to evaluate the diagnostic role of LUS in neonates with MAS.

Materials and methods: A systematic literature search was conducted in PubMed and Google Scholar in accordance with the PRISMA 2020 guidelines. Original studies involving neonates with MAS and reporting MAS-specific LUS data were included. Studies were excluded if they were non-English, animal studies, lacked original data, involved non-MAS populations or focused on therapy guidance rather than diagnosis.

Results: Five studies met the inclusion criteria. Across the included studies, LUS demonstrated high diagnostic performance for MAS, with reported sensitivity ranging from 90% to 100% and specificity 99.3% to 100%. Characteristic LUS findings included lung consolidations with air bronchogram, pleural line abnormalities, disappearance of A-lines and alveolar-interstitial syndrome.

Conclusions: LUS appears to be a reliable diagnostic tool for MAS and offers important advantages including absence of ionizing radiation and bedside applicability. It may be considered a first-line imaging modality in infants with suspected MAS, with chest X-ray reserved for cases of diagnostic uncertainty. Further studies are needed to confirm these findings.

References

Alonso-Ojembarrena, A., Gregorio-Hernández, R., & Raimondi, F. (2024). Neonatal point-of-care lung ultrasound: What should be known and done out of the NICU? European Journal of Pediatrics, 183(4), 1555–1565. https://doi.org/10.1007/s00431-023-05375-5

Chen, S.-W., Fu, W., Liu, J., & Wang, Y. (2017). Routine application of lung ultrasonography in the neonatal intensive care unit. Medicine, 96(2), Article e5826. https://doi.org/10.1097/MD.0000000000005826

Copetti, R., & Cattarossi, L. (2007). The “double lung point”: An ultrasound sign diagnostic of transient tachypnea of the newborn. Neonatology, 91(3), 203–209. https://doi.org/10.1159/000097454

Feng, Z., & Huang, N. (2025). Research on the diagnostic precision of ultrasound imaging characteristics of common neonatal pulmonary disorders: A cross-sectional study. Iranian Journal of Pediatrics, 35(3), Article e156840. https://doi.org/10.5812/ijped-156840

Ismail, R., Raggal, N. M. E., Hegazy, L. A., Sakr, H. M., Eldafrawy, O. A., & Farid, Y. A. (2023). Lung ultrasound role in diagnosis of neonatal respiratory disorders: A prospective cross-sectional study. Children, 10(1), Article 173. https://doi.org/10.3390/children10010173

Liu, J., Cao, H.-Y., & Fu, W. (2016). Lung ultrasonography to diagnose meconium aspiration syndrome of the newborn. Journal of International Medical Research, 44(6), 1534–1542. https://doi.org/10.1177/0300060516663954

Lovrenski, J., Raissaki, M., Plut, D., Alexopoulou, E., Görkem, S. B., Ozcan, H. N., Geiger, J., Gräfe, D., Sileo, C., Caro-Dominguez, P., & Ciet, P. (2025). ESR essentials: Imaging of common paediatric pulmonary diseases—Practice recommendations by the European Society of Paediatric Radiology. European Radiology, 35(8), 5037–5052. https://doi.org/10.1007/s00330-024-11268-4

Monfredini, C., Cavallin, F., Villani, P. E., Paterlini, G., Allais, B., & Trevisanuto, D. (2021). Meconium aspiration syndrome: A narrative review. Children, 8(3), Article 230. https://doi.org/10.3390/children8030230

Pereda, M. A., Chavez, M. A., Hooper-Miele, C. C., Gilman, R. H., Steinhoff, M. C., Ellington, L. E., Gross, M., Price, C., Tielsch, J. M., & Checkley, W. (2015). Lung ultrasound for the diagnosis of pneumonia in children: A meta-analysis. Pediatrics, 135(4), 714–722. https://doi.org/10.1542/peds.2014-2833

Piastra, M., Yousef, N., Brat, R., Manzoni, P., Mokhtari, M., & De Luca, D. (2014). Lung ultrasound findings in meconium aspiration syndrome. Early Human Development, 90, S41–S43. https://doi.org/10.1016/S0378-3782(14)50011-4

Popa, A. E., Popescu, S. D., Tecuci, A., & Vladareanu, S. (2024). Lung ultrasound and ultrasound score: A useful tool in neonatal intensive care units for the diagnosis and therapeutic management of newborns with respiratory pathology. Cureus, 16(8), Article e66064. https://doi.org/10.7759/cureus.66064

Qiu, R.-X., Ren, X.-L., Liu, J., Li, J.-J., Gao, Y.-Q., & Xia, R.-M. (2019). Bronchoalveolar lavage to treat neonatal meconium aspiration syndrome under monitoring of lung ultrasound based on a prospective case series study. Iranian Journal of Pediatrics, 29(4), Article e90012. https://doi.org/10.5812/ijp.90012

Raimondi, F., Migliaro, F., Sodano, A., Ferrara, T., Lama, S., Vallone, G., & Capasso, L. (2014). Use of neonatal chest ultrasound to predict noninvasive ventilation failure. Pediatrics, 134(4), e1089–e1094. https://doi.org/10.1542/peds.2013-3924

Swarnam, K., Soraisham, A. S., & Sivanandan, S. (2012). Advances in the management of meconium aspiration syndrome. International Journal of Pediatrics, 2012, Article 359571. https://doi.org/10.1155/2012/359571

Volpicelli, G., Elbarbary, M., Blaivas, M., Lichtenstein, D. A., Mathis, G., Kirkpatrick, A. W., Melniker, L., Gargani, L., Noble, V. E., Via, G., Dean, A., Tsung, J. W., Soldati, G., Copetti, R., Bouhemad, B., Reissig, A., Agricola, E., Rouby, J.-J., Arbelot, C., et al. (2012). International evidence-based recommendations for point-of-care lung ultrasound. Intensive Care Medicine, 38(4), 577–591. https://doi.org/10.1007/s00134-012-2513-4

Wu, J., Su, C., & Mao, Y. (2024). The value of lung ultrasound in the differential diagnosis of common lung diseases in newborns. Medicine, 103(45), Article e40459. https://doi.org/10.1097/MD.0000000000040459

Downloads

Published

2026-03-15

How to Cite

Mazurek, K., Wojciechowicz, M., Brzęcka, M., Rogiński, S., Chojnowski, Łukasz, Dominiczak, A., Rogiński, K., Szlęzak, K. ., Kryca, K., & Rogińska, K. (2026). LUNG ULTRASOUND IN THE DIAGNOSIS OF MECONIUM ASPIRATION SYNDROME IN NEONATES: A SYSTEMATIC REVIEW. International Journal of Innovative Technologies in Social Science, 5(1(49). https://doi.org/10.31435/ijitss.1(49).2026.4972