THE ROLE OF THE ANESTHESIOLOGIST IN THE MANAGEMENT OF CRITICALLY ILL SEPTIC PATIENTS: A CLINICAL LITERATURE REVIEW
DOI:
https://doi.org/10.31435/ijitss.1(49).2026.5062Keywords:
Sepsis, Septic Shock, Anesthesia Management, Critically Ill Patients, Perioperative Care, Hemodynamic MonitoringAbstract
Sepsis and septic shock are acute, life threatening syndromes in which infection triggers widespread organ dysfunction and rapid clinical deterioration, demanding fast, coordinated action from multiple specialties. In patients who require surgical source control, the anesthesiologist becomes central to perioperative management, because decisions made in the operating room directly influence perfusion, oxygen delivery, and the safety of the procedure. This review focuses on the anesthesiologist’s tasks before, during, and after surgery, with particular attention to how sepsis alters usual anesthetic practice. In unstable patients, careful evaluation of organ failure, cautious choice and dosing of induction drugs (often favoring ketamine or etomidate rather than propofol), advanced monitoring with individually tailored fluid therapy, lung protective ventilation, and timely escalation to vasopressor support are all essential to reduce perioperative risk. Current Surviving Sepsis Campaign recommendations underline that effective source control should be achieved as early as possible, ideally within the first 6 hours from recognizing sepsis, which places anesthesiologists in a key position to balance the urgency of surgery with the need for initial resuscitation. A solid grasp of sepsis pathophysiology and its hemodynamic consequences is therefore fundamental for anesthesiologists involved in the care of these critically ill patients.
References
Evans, L., Rhodes, A., Alhazzani, W., Antonelli, M., Coopersmith, C. M., French, C., Machado, F. R., McIntyre, L., Ostermann, M., Prescott, H. C., Schorr, C., Simpson, S., Wiersinga, W. J., Alshamsi, F., Angus, D. C., Arabi, Y., Azevedo, L., Beale, R., Beilman, G., ... Levy, M. (2021). Surviving sepsis campaign: International guidelines for management of sepsis and septic shock 2021. Intensive Care Medicine, 47(11), 1181–1247. https://doi.org/10.1007/s00134-021-06506-y
Singer, M., Deutschman, C. S., Seymour, C. W., Shankar-Hari, M., Annane, D., Bauer, M., Bellomo, R., Bernard, G. R., Chiche, J. D., Coopersmith, C. M., Hotchkiss, R. S., Levy, M. M., Marshall, J. C., Martin, G. S., Opal, S. M., Rubenfeld, G. D., van der Poll, T., Vincent, J.-L., & Angus, D. C. (2016). The third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA, 315(8), 801–810. https://doi.org/10.1001/jama.2016.0287
La Via, L., Maniaci, A., Lentini, M., Cuttone, G., Ronsivalle, S., Sangiorgio, G., Stefani, S., Marino, A., Nunnari, G., Cocuzza, S., La Mantia, I., Cacopardo, B., Stracquadanio, S., Spampinato, S., & Lavalle, S. (2025). The burden of sepsis and septic shock in the intensive care unit. Journal of Clinical Medicine, 14(19), 6691. https://doi.org/10.3390/jcm14196691
Santacroce, E., D’Angerio, M., Ciobanu, A. L., Masini, L., Lo Tartaro, D., Coloretti, I., & Busani, S. (2024). Advances and challenges in sepsis management: Modern tools and future directions. Cells, 13(5), 439. https://doi.org/10.3390/cells13050439
Carsetti, A., Vitali, E., Pesaresi, L., Antolini, R., Casarotta, E., Damiani, E., Adrario, E., & Donati, A. (2023). Anesthetic management of patients with sepsis/septic shock. Frontiers in Medicine, 10, Article 1150124. https://doi.org/10.3389/fmed.2023.1150124
De Waele, J. J., Bos, M. J., & Schultz, M. J. M. (2024). Importance of timely and adequate source control in sepsis and septic shock. Journal of Intensive Medicine, 4(3), 281–286. https://doi.org/10.1016/j.jointm.2024.01.002
Reitz, K. M., Kennedy, J. N., Li, S. R., Handzel, R. M., Tonetti, D. A., Neal, M. D., Sperry, J. L., Zuckerbraun, B. S., Hall, D. E., Tzeng, E., Angus, D. C., & Seymour, C. W. (2022). Association between time to source control in sepsis and 90-day mortality. JAMA Surgery, 157(9), 817–826. https://doi.org/10.1001/jamasurg.2022.2761
Cecconi, M., Parsons, A. K., & Rhodes, A. (2011). What is a fluid challenge? Current Opinion in Critical Care, 17(3), 290–295. https://doi.org/10.1097/MCC.0b013e32834699cd
Hyun, D. G., Lee, S. H., Kim, H. J., Park, J. S., Choi, J. H., Kim, J., Lee, Y. J., Jeon, K., Park, S. Y., & Lim, C.-M. (2025). Optimal time and volume of fluid resuscitation in patients with sepsis: A nationwide multicenter cohort study. Scientific Reports, 15(1), 30465. https://doi.org/10.1038/s41598-025-14854-8
Prescott, H. C., & Ostermann, M. (2023). What is new and different in the 2021 Surviving Sepsis Campaign guidelines. Medizinische Klinik - Intensivmedizin und Notfallmedizin, 118(Suppl 2), 75–79. https://doi.org/10.1007/s00063-023-01028-5
Wan, C., Hanson, A. C., Schulte, P. J., Dong, Y., & Bauer, P. R. (2021). Propofol, ketamine, and etomidate as induction agents for intubation and outcomes in critically ill patients: A retrospective cohort study. Critical Care Explorations, 3(5), e0435. https://doi.org/10.1097/CCE.0000000000000435
Mohr, N. M., Pape, S. G., Runde, D., Kaji, A. H., Walls, R. M., & Brown, C. A. (2020). Etomidate use is associated with less hypotension than ketamine for emergency department sepsis intubations: A NEAR cohort study. Academic Emergency Medicine, 27(11), 1140–1149. https://doi.org/10.1111/acem.14070
Srivilaithon, W., Bumrungphanithaworn, A., Daorattanachai, K., Limsuwat, C., Aree-On, N., Inrung, W., Dechert, N., Dechasiri, I., Sangmuang, Y., Udomphonphiphat, T., Phungoen, V., & Akaraborworn, O. (2023). Clinical outcomes after a single induction dose of etomidate versus ketamine for emergency department sepsis intubation: A randomized controlled trial. Scientific Reports, 13, 6362. https://doi.org/10.1038/s41598-023-33679-x
Nunnally, M. E. (2016). Sepsis for the anaesthetist. BJA: British Journal of Anaesthesia, 117(Suppl 3), iii44–iii52. https://doi.org/10.1093/bja/aew333
Bhattacharjee, A., Datta, P. K., Kumar, V., Ravikumar, R. H., Sathe, P., & Kundu, R. (2025). Timing of vasopressin initiation in patients with septic shock: An updated systematic review and meta-analysis with trial sequential analysis. Indian Journal of Critical Care Medicine, 29(10), 839–850. https://doi.org/10.5005/jp-journals-10071-25054
Young, C. C., Harris, E. M., Vacchiano, C., Bodnar, S., Bukowy, B., Elliott, R. R. D., Migliarese, J., Ragains, C., Trethewey, B., Woodward, A., & Faust, R. J. (2019). Lung-protective ventilation for the surgical patient: International expert panel-based consensus recommendations. British Journal of Anaesthesia, 123(6), 898–913. https://doi.org/10.1016/j.bja.2019.08.017
Alizada, M., Hancı, V., Bıçak, M., Girgin, N. K., & Ekinci, A. (2025). Evaluation of sepsis frequency and affecting factors in postoperative intensive care unit: A prospective observational study. Medicine, 104(40), e44919. https://doi.org/10.1097/MD.0000000000044919
Stefani, L. C., Gamermann, P. W., Backof, A., Guollo, F., Luciano, R., & Silva, M. C. V. (2018). Perioperative mortality related to anesthesia within 48 h and up to 30 days following surgery: A retrospective cohort study. Journal of Clinical Anesthesia, 49, 63–67. https://doi.org/10.1016/j.jclinane.2018.06.025
Niebhagen, F., Heubner, L., Kirsch, A., Güldner, A., Held, H.-C., Schneider, R., Bodechtel, U., Mehrholz, J., Koch, T., Menk, M., & Spieth, P. (2025). Long-term characteristics and outcomes of septic critically ill patients with and without COVID-19. Journal of Critical Care, 82, Article 154942. https://doi.org/10.1016/j.jcrc.2024.154942
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Copyright (c) 2026 Maja Osuch, Maciej Osuch, Olga Tatarata, Martyna Jaciubek, Carmena Luty, Amanda Abramowicz, Magdalena Rumin, Anna Kiełboń, Zuzanna Olga Reklewska, Kornelia Domagała

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