A 10-YEAR FOLLOW-UP OF CHILDHOOD-ONSET RECURRENT UNILATERAL IDIOPATHIC ANTERIOR UVEITIS: A CASE REPORT

Daria Valipur Kolti; Kacper Cholewiński; Julia Kierner; Natalia Sara Kuśmierowska; Tymoteusz Białowąs; Dominika Karolak; Monika Kuś; Milena Polak; Konrad Wiśniewski; Magdalena Natalia Nowak; Grzegorz Słomkowski

doi:10.31435/ijitss.1(49).2026.5123

Authors

Daria Valipur Kolti Medical University of Warsaw, Poland https://orcid.org/0009-0005-9900-4419
Kacper Cholewiński Medical University of Warsaw, Poland https://orcid.org/0009-0004-7185-5310
Julia Kierner Medical University of Warsaw, Poland https://orcid.org/0009-0004-2962-3735
Natalia Sara Kuśmierowska Medical University of Warsaw, Poland https://orcid.org/0009-0006-7572-0282
Tymoteusz Białowąs Medical University of Warsaw, Poland https://orcid.org/0009-0001-0889-2635
Dominika Karolak Medical University of Warsaw, Poland https://orcid.org/0009-0007-1131-9171
Monika Kuś Medical University of Warsaw, Poland https://orcid.org/0009-0009-6445-5593
Milena Polak Medical University of Warsaw, Poland https://orcid.org/0009-0007-6148-5354
Konrad Wiśniewski Cardinal Stefan Wyszyński University in Warsaw, Collegium Medicum, Poland https://orcid.org/0009-0007-1076-6471
Magdalena Natalia Nowak Cardinal Stefan Wyszyński University in Warsaw, Collegium Medicum, Poland https://orcid.org/0009-0002-1010-3364
Grzegorz Słomkowski Medical University of Warsaw, Poland https://orcid.org/0009-0003-3742-8377

DOI:

https://doi.org/10.31435/ijitss.1(49).2026.5123

Keywords:

Cytokines, Idiopathic Anterior Uveitis, Local Immune Mechanisms, Recurrent Uveitis, Targeted Therapy

Abstract

Idiopathic anterior uveitis accounts for a significant portion of uveitis and is responsible for localized intraocular inflammation. The case presents a long-term follow-up of a 38-year-old patient with a unilateral, recurrent and childhood-onset IAU. The patient encounters flare-ups approximately every six months, which are treated with topical corticosteroids and mydriatics, leading to quick resolution without lasting complications or visual acuity decline. Comprehensive diagnostic work-up ruled out infectious and autoimmune causes, highlighting the disease's purely ocular involvement. Examination of local immune reactions in the anterior chamber of eyes affected by IAU is crucial, as together with immune memory may persist even after clinical recovery. These mechanisms account for the persistent nature of inflammation and the drawbacks of existing topical treatments, which manage acute flare-ups but fail to address the fundamental immune dysregulation. New targeted strategies, such as locally delivered biologics or cytokine-modulating agents, could reduce recurrence while limiting systemic exposure.

This case highlights the significance of localized ocular immune activation and underscores the necessity for treatments aimed at the root immunopathogenesis of IAU.

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