WOUND CARE IN THE AGING POPULATION: CURRENT MANAGEMENT AND FUTURE DIRECTIONS
DOI:
https://doi.org/10.31435/ijitss.2(50).2026.5209Keywords:
Wound Management, Elderly, Personalized Medicine, Frailty, DressingsAbstract
As global demographics shift toward an aging population, wound management in the elderly has become a clinical challenge. Wound management in this demographic is uniquely complex, requiring an understanding of age-specific changes and the multisystemic nature of geriatric health. This article focuses on challenges in geriatric wound care, specifically on how the skin's physical structure changes over time, the diverse range of treatment methods currently available, and the often-overlooked impact of a patient’s socioeconomic status on their recovery. One of the assessment tools being used nowadays is the Clinical Frailty Scale (CFS), which, by shifting focus from chronological age to a patient's functional independence and comorbidity load, can better quantify their risk of complications. Current research into novel therapies, particularly the use of specialized wound dressings, advanced drug therapies and the integration of artificial intelligence, shows promising ways of predicting complications and personalizing care for older adults. Effective wound management in the elderly requires a transition from traditional episodic care to a multidisciplinary, technology-enhanced approach.
References
Chrysostomou, D., Pokorná, A., Cremers, N. A. J., & Peters, L. J. F. (2024). Medical-grade honey is a versatile wound care product for the elderly. Journal of Aging Research and Lifestyle, 13, 51–59. https://doi.org/0.14283/jarlife.2024.7
Khalid, K. A., Mohd Nawi, A. F., Zulkifli, N., Barkat, M. A., & Hadi, H. (2022). Aging and wound healing of the skin: A review of clinical and pathophysiological hallmarks. Life, 12(12), 2142. https://doi.org/10.3390/life12122142
Romanowski, K. S., & Sen, S. (2022). Wound healing in older adults with severe burns: Clinical treatment considerations and challenges. Burns Open, 6(2), 57–64. https://doi.org/10.1016/j.burnso.2022.01.002
Jain, K., Avsar, P., Patton, D., Moore, Z., & Murray, B. (2025). What specific challenges do patients with chronic wounds encounter when attending medical appointments related to wound care? A systematic review. Journal of Tissue Viability, 34(1). https://doi.org/10.1016/j.jtv.2025.100865
Makrantonaki, E., Wlaschek, M., & Scharffetter-Kochanek, K. (2017). Pathogenesis of wound healing disorders in the elderly. Journal der Deutschen Dermatologischen Gesellschaft, 15(3), 255–275. https://doi.org/10.1111/ddg.13199
Johnston, M., & Swarbrick, C. J. (2024). Frailty and multimorbidity in perioperative care. BJA Education, 24(1), 19–27. https://doi.org/10.1016/j.mpmed.2024.10.008
Upton, L. (2020). What is the effect of age on wound healing in the acute trauma setting? A scoping review. Wound Practice and Research, 28(3), 115–126. https://doi.org/10.33235/wpr.28.3.115-126
Chalk, F., & Palmer, A. (2025). The impact of ageing and frailty on wound healing. British Journal of Nursing, 34(20), S27–S34. https://doi.org/10.12968/bjon.2025.0023
Ding, X., Kakanj, P., Leptin, M., & Eming, S. A. (2021). Regulation of the wound healing response during aging. Journal of Investigative Dermatology, 141(4S), 1063–1070. https://doi.org/10.1016/j.jid.2020.11.014
Garcia-Martinez, D., Leyva-Mendivil, M. F., Gefen, A., & Limbert, G. (2020). Biomechanical aspects of skin aging—the risk of skin breakdown under shear loading increases with age. In A. Gefen (Ed.), Innovations and emerging technologies in wound care (pp. 309–335). Academic Press. https://doi.org/10.1016/B978-0-12-815028-3.00017-1
Ozgok Kangal, M. K., & Kopitnik, N. L. (2025). Physiology, wound healing. In StatPearls. StatPearls Publishing.
Shaw, T. J., & Martin, P. (2009). Wound repair at a glance. Journal of Cell Science, 122(18), 3209–3213. https://doi.org/10.1242/jcs.031187
Whittam, A. J., Maan, Z. N., Duscher, D., Wong, V. W., Barrera, J. A., Januszyk, M., & Gurtner, G. C. (2016). Challenges and opportunities in drug delivery for wound healing. Advances in Wound Care, 5(2), 79–88. https://doi.org/10.1089/wound.2014.0600
Zou, L., Wang, X., Zhang, Z., Yang, T., & Zong, J. (2023). Dynamics of microbial communities in chronic wounds and their role in wound healing. International Journal of Clinical and Experimental Medical Research, 7(4), 696–700. https://doi.org/10.26855/ijcemr.2023.10.032
Greenhalgh, D. G. (2015). Management of the skin and soft tissue in the geriatric surgical patient. Surgical Clinics of North America, 95(1), 103–114. https://doi.org/10.1016/j.suc.2014.09.008
Harris, C. L., & Fraser, C. (2004). Malnutrition in the institutionalized elderly: The effects on wound healing. Ostomy Wound Management, 50(10), 54–63.
Morley, J. E., & Silver, A. J. (1988). Anorexia in the elderly. Neurobiology of Aging, 9(1), 9–16. https://doi.org/10.1016/s0197-4580(88)80004-6
Blass, S. C., Goost, H., Tolba, R. H., Stoffel-Wagner, B., Kabir, K., Burger, C., Stehle, P., & Ellinger, S. (2012). Time to wound closure in trauma patients with disorders in wound healing is shortened by supplements containing antioxidant micronutrients and glutamine: A PRCT. Clinical Nutrition, 31(4), 469–475. https://doi.org/10.1016/j.clnu.2012.01.002
Henry, J. C., Peterson, L., Schlanger, R. E., Go, M. R., Sen, C. K., & Higgins, R. S. D. (2024). Wound healing in peripheral arterial disease: Current and future therapy. Journal of Vascular Medicine & Surgery, 2. https://doi.org/10.4172/2329-6925.1000157
Nokaneng, E., Heerschap, C., Thayer, D., Ousey, K., Holloway, S., LeBlanc, K., Netsch, D., Vance, H., Emmons, K. R., & Woo, K. (2025). Best practice recommendations for the prevention and management of skin tears in aged skin (2nd ed.). Wounds International. https://woundsinternational.com/consensus-documents/best-practice-recommendations-for-the-prevention-and-management-of-skin-tears-in-aged-skin-2nd-edition/
Dhar, A., Needham, J., Gibb, M., & Coyne, E. (2024). The client and family experience of attending a nurse-led clinic for chronic wounds. Australian Journal of Primary Health, 30(1). https://doi.org/10.1071/PY23081
Kapp, S., Miller, C., & Santamaria, N. (2018). The quality of life of people who have chronic wounds and who self-treat. Journal of Clinical Nursing, 27(1–2), 182–192. https://doi.org/10.1111/jocn.13870
Michael, G. C., Grema, B. A., Ashimi, A. O., Olawumi, A. L., Umar, Z. A., Mahmoud, Z., & Aji, S. A. (2022). Predictors of satisfaction with wound care services in an outpatient setting in Kano, Nigeria. West African Journal of Medicine, 39(8), 800–807.
Swan, J., Mogford, J., & Leek, K. (2024). Wound care in older people: Overcoming the challenges of assessment and management. Nursing Older People. https://doi.org/10.7748/nop.2024.e1471
National Institute for Health and Care Excellence. (2024). Skin care and management of fragile skin. NICE. https://cks.nice.org.uk/topics/skin-care-management-of-fragile-skin/
Nur, M. G., Rahman, M., Dip, T. M., Hossain, M. H., Hossain, N. B., Baratchi, S., Padhye, R., & Houshyar, S. (2025). Recent advances in bioactive wound dressings. Wound Repair and Regeneration, 33(1), e13233. https://doi.org/10.1111/wrr.13233
Ding, X., Li, Z., Zhang, X., Zhou, S., & Xue, C. (2024). Challenges and innovations in treating chronic and acute wound infections: From basic science to clinical practice. Burns & Trauma, 12, tkad054. https://doi.org/10.1093/burnst/tkac014
Li, A., Jing, Z., Liu, Y., & Wang, Y. (2024). Nanofiber-based wound dressing in wound healing of elderly patients. Postępy Dermatologii i Alergologii, 41(1), 121–127. https://doi.org/10.5114/ada.2024.136034
Fan, R., Cheng, Y., Wang, R., Zhang, T., Zhang, H., Li, J., Song, S., & Zheng, A. (2022). Thermosensitive hydrogels and advances in their application in disease therapy. Polymers, 14(12), 2379. https://doi.org/10.3390/polym14122379
Yun, E. J., Yon, B., Joo, M. K., & Jeong, B. (2012). Cell therapy for skin wound using fibroblast encapsulated poly(ethylene glycol)-poly(L-alanine) thermogel. Biomacromolecules, 13(4), 1106–1111. https://doi.org/10.1021/bm2018596
Lv, T., Chen, Y., Li, N., Liao, X., Heng, Y., Guo, Y., & Hu, K. (2025). A comprehensive review of thermosensitive hydrogels: Mechanism, optimization strategies, and applications. Gels, 11(7), 544. https://doi.org/10.3390/gels11070544
Pan, W., Wu, B., Nie, C., Luo, T., Song, Z., Lv, J., Tan, Y., Liu, C., Zhong, M., Liao, T., Wang, Z., Yi, G., Zhang, L., Liu, X., Li, B., Chen, J., & Zheng, L. (2023). NIR-II responsive nanohybrids incorporating thermosensitive hydrogel as sprayable dressing for multidrug-resistant-bacteria infected wound management. ACS Nano, 17(12), 11253–11267. https://doi.org/10.1021/acsnano.2c10742
Reshmi, C. R., Suja, P. S., Manaf, O., Sanu, P. P., & Sujith, A. (2018). Nanochitosan enriched poly ε-caprolactone electrospun wound dressing membranes: A fine tuning of physicochemical properties, hemocompatibility and curcumin release profile. International Journal of Biological Macromolecules, 108, 1261–1272. https://doi.org/10.1016/j.ijbiomac.2017.11.035
Liu, Y., & Ge, L. (2025). Smart biomaterials in wound healing: Advances, challenges, and future directions in intelligent dressing design. Bioengineering, 12(11), 1178. https://doi.org/10.3390/bioengineering12111178
Ren, Y., Yu, X., Li, Z., Liu, D., & Xue, X. (2020). Fabrication of pH-responsive TA-keratin bio-composited hydrogels encapsulated with photoluminescent GO quantum dots for improved bacterial inhibition and healing efficacy in wound care management: In vivo wound evaluations. Journal of Photochemistry and Photobiology B: Biology, 202, 111676. https://doi.org/10.1016/j.jphotobiol.2019.111676
De Piano, R., Barra, F., Caccavo, D., Barba, A. A., & Lamberti, G. (2026). Design of pH-sensitive alginate-carbopol hydrogel patches for wound healing applications. International Journal of Pharmaceutics, 688, 126469. https://doi.org/10.1016/j.ijpharm.2025.126469
Alka, Singh, P., Pal, R. R., Mishra, N., Singh, N., Verma, A., & Saraf, S. A. (2024). Development of pH-sensitive hydrogel for advanced wound healing: Graft copolymerization of locust bean gum with acrylamide and acrylic acid. International Journal of Pharmaceutics, 661, 124450. https://doi.org/10.1016/j.ijpharm.2024.124450
Li, W., Tan, X., Liang, Y., Chen, N., Feng, D., Tao, Y., Liu, T., Wu, X., Lu, H., & Liu, L. (2025). Multifunctional microneedle patch synergized with electrical stimulation to regulate microenvironment for enhanced healing of infected diabetic wounds. Chemical Engineering Journal, 505, 159255. https://doi.org/10.1016/j.cej.2025.159255
Liu, Z., Liu, J., Sun, T., Zeng, D., Yang, C., Wang, H., Yang, C., Guo, J., Wu, Q., Chen, H. J., & Xie, X. (2021). Integrated multiplex sensing bandage for in situ monitoring of early infected wounds. ACS Sensors, 6(8), 3112–3124. https://doi.org/10.1021/acssensors.1c01279
Wang, C., Shirzaei Sani, E., Shih, C. D., Lim, C. T., Wang, J., Armstrong, D. G., & Gao, W. (2024). Wound management materials and technologies from bench to bedside and beyond. Nature Reviews Materials, 9(8), 550–566. https://doi.org/10.1038/s41578-024-00693-y
Naghib, S. M., Matini, A., Amiri, S., Ahmadi, B., & Mozafari, M. R. (2024). Exploring the potential of polysaccharides-based injectable self-healing hydrogels for wound healing applications: A review. International Journal of Biological Macromolecules, 282(Pt. 5), 137209. https://doi.org/10.1016/j.ijbiomac.2024.137209
Kwakman, P. H., Krijgsveld, J., de Boer, L., Nguyen, L. T., Boszhard, L., Vreede, J., Dekker, H. L., Speijer, D., Drijfhout, J. W., te Velde, A. A., Crielaard, W., Vogel, H. J., Vandenbroucke-Grauls, C. M., & Zaat, S. A. (2011). Native thrombocidin-1 and unfolded thrombocidin-1 exert antimicrobial activity via distinct structural elements. Journal of Biological Chemistry, 286(50), 43506–43514. https://doi.org/10.1074/jbc.M111.248641
Cresti, L., Cappello, G., & Pini, A. (2024). Antimicrobial peptides towards clinical application—A long history to be concluded. International Journal of Molecular Sciences, 25(9), 4870. https://doi.org/10.3390/ijms25094870
Mullin, J. A., Rahmani, E., Kiick, K. L., & Sullivan, M. O. (2023). Growth factors and growth factor gene therapies for treating chronic wounds. Bioengineering & Translational Medicine, 9(3), e10642. https://doi.org/10.1002/btm2.10642
Farabi, B., Roster, K., Hirani, R., Tepper, K., Atak, M. F., & Safai, B. (2024). The efficacy of stem cells in wound healing: A systematic review. International Journal of Molecular Sciences, 25(5), 3006. https://doi.org/10.3390/ijms25053006
Huang, J., Yu, M., Yin, W., Liang, B., Li, A., Li, J., Li, X., Zhao, S., & Liu, F. (2021). Development of a novel RNAi therapy: Engineered miR-31 exosomes promoted the healing of diabetic wounds. Bioactive Materials, 6(9), 2841–2853. https://doi.org/10.1016/j.bioactmat.2021.02.007
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Copyright (c) 2026 Karolina Lach, Anna Kułach, Wiktoria Modrzejewska, Gabriela Krok, Katarzyna Siwiec, Maria Chmielewska, Weronika Basak, Zofia Wcisło, Łukasz Lamparski, Patrycja Piekarska
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