CONTEMPORARY MANAGEMENT OF PEDIATRIC OBESITY: A NARRATIVE REVIEW
DOI:
https://doi.org/10.31435/ijitss.2(50).2026.5342Keywords:
Pediatric Obesity; Childhood Obesity; Adolescent Obesity; Obesity Managements; GLP-1 Agonists; Surgery, Bariatric; Surgery, MetabolicAbstract
Background: Pediatric obesity is widely regarded as a heterogeneous, chronic disease associated with metabolic, cardiovascular, and psychosocial consequences. Its increasing prevalence highlights the need for comprehensive, evidence-based management strategies.
Aims: This narrative review aims to synthesize current evidence on therapeutic approaches for pediatric obesity, including behavioral management, pharmacologic and surgical treatment, and to highlight emerging treatment directions.
Methods: A narrative review was based on a PubMed search, covering studies published through February 2026. Search terms included keywords related to pediatric obesity and related management strategies. Eligible studies included clinical trials, observational studies, systematic reviews, meta-analyses, and clinical guidelines evaluating treatment outcomes in patients aged under 18 years. Evidence was synthesized according to SANRA guidelines.
Results: Lifestyle and behavioral interventions persist as the foundation of pediatric obesity management. However, their long-term effectiveness is often suboptimal. Glucagon-like-peptide-1 receptor agonists demonstrate meaningful reductions in BMI along with improvement of obesity-related comorbidities, representing a substantial advancement in pharmacologic therapy. In cases of children with severe obesity not responding to conservative and medical treatment, the most significant weight reduction is provided by metabolic and bariatric surgery. Emerging therapies that target metabolic pathways and the gut microbiome appear promising, yet require additional validation.
Conclusions: The treatment and management of pediatric obesity is shifting toward a tailored approach integrating behavioral, pharmacologic, and surgical strategies. Novel pharmacotherapies have significantly expanded treatment options, but long-term safety data and comparative studies remain limited. Multidisciplinary, individualized care is crucial to optimize outcomes in this complex disease.
References
Hampl, S. E., Hassink, S. G., Skinner, A. C., Armstrong, S. C., Barlow, S. E., Bolling, C. F., et al. (2023). Clinical practice guideline for the evaluation and treatment of children and adolescents with obesity. Pediatrics, 151(2), Article e2022060640. https://doi.org/10.1542/peds.2022-060640
Codazzi, V., Frontino, G., Galimberti, L., Giustina, A., & Petrelli, A. (2023). Mechanisms and risk factors of metabolic syndrome in children and adolescents. Endocrine, 84(1), 16–28. https://doi.org/10.1007/s12020-023-03642-x
Stabouli, S., Erdine, S., Suurorg, L., Jankauskienė, A., & Lurbe, E. (2021). Obesity and eating disorders in children and adolescents: The bidirectional link. Nutrients, 13(12), Article 4321. https://doi.org/10.3390/nu13124321
Fox, C. K., Kelly, A. S., Reilly, J. L., et al. (2025). Current and future state of pharmacological management of pediatric obesity. International Journal of Obesity, 49, 388–396. https://doi.org/10.1038/s41366-024-01465-y
Maffeis, C., Olivieri, F., Valerio, G., Verduci, E., Licenziati, M. R., Calcaterra, V., et al. (2023). The treatment of obesity in children and adolescents: Consensus position statement of the Italian societies. Italian Journal of Pediatrics, 49(1). https://doi.org/10.1186/s13052-023-01458-z
Salam, R. A., Padhani, Z. A., Das, J. K., Shaikh, A. Y., Hoodbhoy, Z., Jeelani, S. M., et al. (2020). Effects of lifestyle modification interventions to prevent and manage child and adolescent obesity: A systematic review and meta-analysis. Nutrients, 12(8), Article 2208. https://doi.org/10.3390/nu12082208
Epstein, L. H., Wilfley, D. E., Kilanowski, C., Quattrin, T., Cook, S. R., Eneli, I. U., et al. (2023). Family-based behavioral treatment for childhood obesity implemented in pediatric primary care. JAMA, 329(22), 1947–1956. https://doi.org/10.1001/jama.2023.8061
Aguilar-Cordero, M. J., León Ríos, X. A., Rojas-Carvajal, A. M., Latorre-García, J., Expósito-Ruiz, M., & Sánchez-López, A. M. (2021). Effects of physical activity on quality of life in overweight and obese children. Nutrición Hospitalaria. https://doi.org/10.20960/nh.03373
Drucker, D. J. (2022). GLP-1 physiology informs the pharmacotherapy of obesity. Molecular Metabolism, 57, Article 101351. https://doi.org/10.1016/j.molmet.2021.101351
Weghuber, D., Barrett, T., Barrientos-Pérez, M., Gies, I., Hesse, D., Jeppesen, O. K., et al. (2022). Once-weekly semaglutide in adolescents with obesity. The New England Journal of Medicine, 387(24), 2245–2257. https://doi.org/10.1056/NEJMoa2208601
Kelly, A. S., Auerbach, P., Barrientos-Perez, M., Gies, I., Hale, P. M., Marcus, C., et al. (2020). A randomized, controlled trial of liraglutide for adolescents with obesity. The New England Journal of Medicine, 382(22), 2117–2128. https://doi.org/10.1056/NEJMoa1916038
Chadda, K. R., Cheng, T. S., & Ong, K. K. (2021). GLP-1 agonists for obesity and type 2 diabetes in children: Systematic review and meta-analysis. Obesity Reviews, 22(6), Article e13177. https://doi.org/10.1111/obr.13177
Ryan, P. M., Seltzer, S., Hayward, N. E., Rodriguez, D. A., Sless, R. T., & Hawkes, C. P. (2021). Safety and efficacy of glucagon-like peptide-1 receptor agonists in children and adolescents with obesity: A meta-analysis. The Journal of Pediatrics, 236, 137–147.e13. https://doi.org/10.1016/j.jpeds.2021.05.009
Armstrong, S. C., Eneli, I., Osganian, S. K., Wagner, B. E., Waldrop, S. W., & Kelly, A. S. (2024). Pediatric obesity pharmacotherapy: State of the science, research gaps, and opportunities. Pediatrics, 154(5), Article e2024067858. https://doi.org/10.1542/peds.2024-067858
Armstrong, S. C., Bolling, C. F., Michalsky, M. P., Reichard, K. W., Haemer, M. A., et al. (2019). Pediatric metabolic and bariatric surgery: Evidence, barriers, and best practices. Pediatrics, 144(6), Article e20193223. https://doi.org/10.1542/peds.2019-3223
Pratt, J. S. A., Browne, A., Browne, N. T., Bruzoni, M., Cohen, M., Desai, A., et al. (2018). ASMBS pediatric metabolic and bariatric surgery guidelines, 2018. Surgery for Obesity and Related Diseases, 14(7), 882–901. https://doi.org/10.1016/j.soard.2018.03.019
Fox, C. K., Barrientos-Pérez, M., Bomberg, E. M., Dcruz, J., Gies, I., Harder-Lauridsen, N. M., et al. (2025). Liraglutide for children 6 to <12 years of age with obesity—A randomized trial. The New England Journal of Medicine, 392(6), 555–565. https://doi.org/10.1056/NEJMoa2407379
Heerman, W. J., Rothman, R. L., Sanders, L. M., Schildcrout, J. S., Flower, K. B., Delamater, A. M., et al. (2024). A digital health behavior intervention to prevent childhood obesity. JAMA, 332(24), 2068–2078. https://doi.org/10.1001/jama.2024.22362
Van Boxel, E. J., Rahman, S., Lai, K., Boulos, N., & Davis, N. (2024). Semaglutide treatment for children with obesity: An observational study. Archives of Disease in Childhood, 109(10), 822–825. https://doi.org/10.1136/archdischild-2023-326687
Bensignor, M. O., Arslanian, S., & Vajravelu, M. E. (2024). Semaglutide for management of obesity in adolescents: Efficacy, safety, and considerations for clinical practice. Current Opinion in Pediatrics, 36(4), 449–455. https://doi.org/10.1097/MOP.0000000000001365
Lee, J. M., Sharifi, M., Oshman, L., Griauzde, D. H., & Chua, K. P. (2024). Dispensing of glucagon-like peptide-1 receptor agonists to adolescents and young adults, 2020–2023. JAMA, 331(23), 2041–2043. https://doi.org/10.1001/jama.2024.7112
Bensignor, M. O., Bramante, C. T., Bomberg, E. M., Fox, C. K., Hale, P. M., Kelly, A. S., et al. (2023). Evaluating potential predictors of weight loss response to liraglutide in adolescents with obesity: A post hoc analysis of the SCALE Teens trial. Pediatric Obesity, 18(9), Article e13061. https://doi.org/10.1111/ijpo.13061
Yang, S., Xin, S., Ju, R., & Zang, P. (2025). Pharmacological interventions for addressing pediatric and adolescent obesity: A systematic review and network meta-analysis. PLOS ONE, 20(2), Article e0314787. https://doi.org/10.1371/journal.pone.0314787
Torbahn, G., Jones, A., Griffiths, A., Matu, J., Metzendorf, M., Ells, L. J., et al. (2024). Pharmacological interventions for the management of children and adolescents living with obesity. Pediatric Obesity, 19(5), Article e13113. https://doi.org/10.1111/ijpo.13113
Coppola, S., Nocerino, R., Paparo, L., Bedogni, G., Calignano, A., Di Scala, C., et al. (2022). Therapeutic effects of butyrate on pediatric obesity. JAMA Network Open, 5(12), Article e2244912. https://doi.org/10.1001/jamanetworkopen.2022.44912
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Copyright (c) 2026 Wiktoria Modrzejewska, Łukasz Lamparski, Grzegorz Szmit, Zofia Wcisło, Weronika Basak, Maria Chmielewska, Patrycja Piekarska, Adrianna Purwin, Katarzyna Siwiec, Anna Kułach, Karolina Lach, Gabriela Krok

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