THE ROLE OF HELICOBACTER PYLORI IN CHRONIC SPONTANEOUS URTICARIA: FROM PATHOGENESIS TO CLINICAL IMPLICATIONS

Anna Kamosińska; Julia Pająk; Antoni Majda; Natalia Sitko; Paulina Makowska; Joanna Gontarczyk; Alicja Laske; Martyna Sowa; Kacper Kucharski; Adam Kowal; Julia Sokołowska; Marcel Dawidowicz

doi:10.31435/ijitss.1(49).2026.5422

Authors

Anna Kamosińska MD, 4th Military Clinical Hospital with Polyclinic, Wrocław, Poland https://orcid.org/0009-0005-0718-2112
Julia Pająk MD, 4th Military Clinical Hospital with Polyclinic, Wrocław, Poland https://orcid.org/0009-0007-0882-9365
Antoni Majda Provincial Specialist Hospital in Wrocław, Wrocław, Poland https://orcid.org/0009-0006-4357-513X
Natalia Sitko Lower Silesian Specialist Hospital T. Marciniak – Emergency Medicine Center, Wrocław, Poland https://orcid.org/0009-0002-4128-134X
Paulina Makowska Voivodeship Specialist Hospital in Wrocław, Wrocław, Poland https://orcid.org/0009-0009-1279-5422
Joanna Gontarczyk University Hospital in Wrocław, Wrocław, Poland https://orcid.org/0009-0002-7512-8853
Alicja Laske 4th Military Clinical Hospital with Polyclinic, Wrocław, Poland https://orcid.org/0009-0000-3690-4659
Martyna Sowa Independent Public Healthcare Facility in Bochnia “District Hospital”, Bochnia, Poland https://orcid.org/0009-0003-7152-5787
Kacper Kucharski Jan Mikulicz Radecki University Clinical Hospital, Wrocław, Poland https://orcid.org/0009-0004-5709-8974
Adam Kowal Jan Mikulicz Radecki University Clinical Hospital, Wrocław, Poland https://orcid.org/0009-0007-7779-598X
Julia Sokołowska Lower Silesian Centre for Oncology, Pulmonology and Hematology, Wrocław, Poland https://orcid.org/0000-0002-7042-0348
Marcel Dawidowicz Lower Silesian Centre for Oncology, Pulmonology and Hematology, Wrocław, Poland https://orcid.org/0009-0000-5297-3507

DOI:

https://doi.org/10.31435/ijitss.1(49).2026.5422

Keywords:

Helicobacter Pylori, Chronic Spontaneous Urticaria, Eradication, CSU, Pathogenesis

Abstract

Background: Chronic spontaneous urticaria (CSU) is characterized by the presence of pruritic wheals persisting for more than 6 weeks, which may or may not be accompanied by angioedema. In recent years, increasing attention has been given to the potential role of infectious factors in the pathogenesis of CSU, including Helicobacter pylori infection, which may represent a contributing factor to disease exacerbation.

Objective: This review aims to evaluate the association between H. pylori infection and chronic spontaneous urticaria. It addresses underlying pathophysiological mechanisms, the impact of bacterial eradication on clinical symptoms, and the clinical relevance of diagnostic and therapeutic approaches.

Methods: A literature review was conducted to assess the association between H. pylori infection and chronic spontaneous urticaria. Studies addressing disease pathomechanisms, the impact of bacterial eradication on the clinical course, and the role of diagnostic and therapeutic strategies were analyzed. Both clinical studies and meta-analyses published in peer-reviewed medical journals were included.

Results: H. pylori infection is more frequently observed in patients with CSU, although its prevalence does not consistently exceed that in the general population. Symptomatic improvement following bacterial eradication has been reported in some patients; however, the correlation remains inconclusive.

Conclusions: H. pylori infection may influence the course of chronic spontaneous urticaria by modulating immune responses and inflammatory processes, which may partly explain symptomatic improvement following eradication. However, study findings remain inconsistent, and limitations such as small patient cohorts and heterogeneity of treatment regimens hinder a definitive assessment of the bacterium’s role in the disease.

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