ANALGOSEDATION IN THE EMERGENCY DEPARTMENT: CURRENT GUIDELINES AND CLINICAL PRACTICE COMPREHENSIVE REVIEW
DOI:
https://doi.org/10.31435/ijitss.2(50).2026.5473Keywords:
Emergency Department, Procedural Sedation, Analgesia, Patient Safety, Monitoring, Ketamine, PropofolAbstract
This article discusses the use of procedural sedation and analgesia (PSA) in the Emergency Department (ED), with an emphasis on ensuring patient safety and comfort during brief medical procedures. The aim of this study is to present the principles of sedation use, its organization, indications, monitoring methods, and potential complications, as well as to emphasize the need for standardized management in the ED.
The methodology is based on a review of available guidelines, classifications (including the ASA system), sedation assessment scales, and an analysis of the pharmacological properties of the most commonly used medications, such as ketamine, propofol, midazolam, fentanyl, and etomidate. Data on patient monitoring and the organization of the clinical workflow are also included.
The results indicate that appropriate selection of sedation levels and medications, as well as close monitoring of vital signs, significantly impacts procedural safety. An individualized approach is crucial, especially in high-risk patient groups (children, the elderly, and trauma patients). The use of combination therapy and alternative techniques, such as nerve blocks, can reduce adverse effects.
The conclusions emphasize the need to implement standards, staff training, and protocols in the ED. Properly performed procedural sedation increases treatment effectiveness, minimizes the risk of complications, and improves patient comfort.
References
American College of Emergency Physicians. (2014). Clinical policy: Procedural sedation and analgesia in the emergency department. Annals of Emergency Medicine, 63(2), 247–258. https://doi.org/10.1016/j.annemergmed.2013.10.015
American Society of Anesthesiologists. (2018). Practice guidelines for moderate procedural sedation and analgesia. Anesthesiology, 128(3), 437–479. https://doi.org/10.1097/ALN.0000000000002043
Beaudoin, F. L., Haran, J. P., & Liebmann, O. (2013). A comparison of ultrasound-guided femoral nerve block versus parenteral opioid analgesia for analgesia in elder patients with hip fractures. Annals of Emergency Medicine, 62(3), 240–246. https://doi.org/10.1016/j.annemergmed.2013.03.019
Bellolio, M. F., Gilani, W. I., Barrionuevo, P., Murad, M. H., Erwin, P. J., Anderson, J. R., Miner, J. R., & Hess, E. P. (2016). Incidence of adverse events in adults undergoing procedural sedation in the emergency department: A systematic review and meta-analysis. Academic Emergency Medicine, 23(2), 119–134. https://doi.org/10.1111/acem.12875
Bhatt, M., Roback, M. G., Brown, L., Farion, K. J., Ali, S., Pancarmy, P., & Johnson, D. W. (2019). Association of preprocedural fasting with outcomes of emergency department sedation in children. JAMA Pediatrics, 173(8), 734–742. https://doi.org/10.1001/jamapediatrics.2019.1413
Burry, L., Rose, L., McCullagh, I. J., Fergusson, D. A., Ferguson, N. D., & Mehta, S. (2014). Daily sedation interruption versus no daily sedation interruption for critically ill adult patients requiring invasive mechanical ventilation. Cochrane Database of Systematic Reviews, 2014(7), Article CD009176. https://doi.org/10.1002/14651858.CD009176.pub2
Burton, J. H., Harrah, J. D., Germann, C. A., & Dillon, C. A. (2006). Does end-tidal carbon dioxide monitoring detect respiratory events prior to onset of arterial oxygen desaturation during emergency department procedural sedation? Annals of Emergency Medicine, 47(2), 139–144. https://doi.org/10.1016/j.annemergmed.2005.08.012
Cappellini, I., Piccini, G. B., Campagnola, L., Consales, G., & De Gaudio, A. R. (2024). Procedural sedation in emergency department: A narrative review. Emergency Care and Medicine, 1(2), 103–136. https://doi.org/10.3390/ecm1020014
Cravero, J. P., Blike, G. T., Beach, M., Gallagher, S. M., Hertzog, J. H., Havidich, J. E., & Gelman, B. (2006). Incidence and nature of adverse events during pediatric sedation/anesthesia for procedures outside the operating room: Report from the Pediatric Sedation Research Consortium. Pediatrics, 118(3), 1087–1096. https://doi.org/10.1542/peds.2006-0313
Deitch, K., Miner, J., Chudnofsky, C. R., Dominici, P., & Latta, D. (2010). Does end-tidal CO₂ monitoring during emergency department procedural sedation and analgesia with propofol lead to fewer hypoxic events? A randomized clinical trial. Annals of Emergency Medicine, 55(3), 258–264. https://doi.org/10.1016/j.annemergmed.2009.08.012
Doyle, D. J., Hendrix, J. M., & Garmon, E. H. (2023). American Society of Anesthesiologists classification. In StatPearls. StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK549785/
European Society of Anaesthesiology. (2018). Guidelines on procedural sedation and analgesia in adults. European Journal of Anaesthesiology, 35(1), 6–24. https://doi.org/10.1097/EJA.0000000000000683
Godwin, S. A., Burton, J. H., Gerardo, C. J., Hatten, B. W., Mace, S. E., Silvers, S. M., & Fesmire, F. M. (2014). Clinical policy: Procedural sedation and analgesia in the emergency department. Annals of Emergency Medicine, 63(2), 247–258. https://doi.org/10.1016/j.annemergmed.2013.10.015
Hohl, C. M., Sadatsafavi, M., Nosyk, B., & Anis, A. H. (2008). Safety and clinical effectiveness of midazolam versus propofol for procedural sedation in the emergency department: A systematic review. Academic Emergency Medicine, 15(1), 1–8. https://doi.org/10.1111/j.1553-2712.2007.00022.x
Hwang, U., & Morrison, R. S. (2007). The geriatric emergency department. Journal of the American Geriatrics Society, 55(11), 1873–1876. https://doi.org/10.1111/j.1532-5415.2007.01400.x
Iqbal, A. U., Shuster, M. E., & Baum, C. R. (2022). Ketofol for procedural sedation and analgesia in the pediatric population. Pediatric Emergency Care, 38(1), 28–33. https://doi.org/10.1097/PEC.0000000000002599
Krauss, B., & Green, S. M. (2006). Procedural sedation and analgesia in children. The Lancet, 367(9512), 766–780. https://doi.org/10.1016/S0140-6736(06)68230-5
Marx, J. A., Hockberger, R. S., & Walls, R. M. (Eds.). (2018). Rosen's emergency medicine: Concepts and clinical practice (9th ed.). Elsevier.
Miller, R. D. (2015). Miller's anesthesia (8th ed.). Elsevier.
Mossakowska, M., Więcek, A., & Błędowski, P. (Eds.). (2012). PolSenior: Aspekty medyczne, psychologiczne, socjologiczne i ekonomiczne starzenia się ludzi w Polsce. Termedia Wydawnictwo Medyczne.
Neufeld, K. J., & Thomas, C. (2013). Delirium: Definition, epidemiology, and diagnosis. Journal of Clinical Neurophysiology, 30(5), 438–442. https://doi.org/10.1097/WNP.0b013e3182a73e31
Owczuk, R. (Ed.). (2022). Anestezjologia i intensywna terapia. PZWL Wydawnictwo Lekarskie.
Reason, J. (2000). Human error: Models and management. BMJ, 320(7237), 768–770. https://doi.org/10.1136/bmj.320.7237.768
Royal College of Emergency Medicine. (2020). Safe sedation in the emergency department. https://rcem.ac.uk/wp-content/uploads/2021/10/Pharmacological_Agents_for_Procedural_Sedation_and_Analgesia_October_2020_Revised_230421.pdf
Sahinovic, M. M., Struys, M. M. R. F., & Absalom, R. A. (2018). Clinical pharmacokinetics and pharmacodynamics of propofol. Clinical Pharmacokinetics, 57(12), 1539–1558. https://doi.org/10.1007/s40262-018-0672-3
Sharif, S., Silveira, L. J., & Guyatt, G. H. (2024). Pharmacological agents for procedural sedation and analgesia in the emergency department and intensive care unit: A systematic review and network meta-analysis of randomised trials. British Journal of Anaesthesia, 132(3), 491–506. https://doi.org/10.1016/j.bja.2023.11.050
Sherwin, T. S., Green, S. M., Khan, A., Chapman, D. S., & Dannenberg, B. (2000). Does adjunctive midazolam reduce recovery agitation after ketamine sedation for pediatric procedures? A randomized, double-blind, placebo-controlled trial. Academic Emergency Medicine, 7(3), 228–235. https://doi.org/10.1111/j.1553-2712.2000.tb01067.x
Smally, A. J., & Nowicki, T. A. (2007). Sedation in the emergency department. Current Opinion in Anaesthesiology, 20(4), 379–383. https://doi.org/10.1097/ACO.0b013e32825a69f9
Smally, A. J., Nowicki, T. A., & Simelton, B. H. (2011). Procedural sedation and analgesia in the emergency department. Current Opinion in Critical Care, 17(4), 317–322. https://doi.org/10.1097/MCC.0b013e328348bf43
Stone, M. B., Wang, R., & Price, D. D. (2008). Ultrasound-guided nerve blocks for ED procedures. Academic Emergency Medicine, 15(1), 89–93. https://doi.org/10.1111/j.1553-2712.2007.00010.x
Strayer, R. J., & Nelson, L. S. (2008). Adverse events associated with ketamine for procedural sedation in adults. The American Journal of Emergency Medicine, 26(9), 985–1028. https://doi.org/10.1016/j.ajem.2007.12.005
Świątkowska, A., & Świątkowska-Bury, M. (2020). Sedacja w stomatologii – aktualne wytyczne anestezjologiczne. Nowa Stomatologia, 25(3), 82–92. https://doi.org/10.25121/NS.2020.25.3.82
Wathen, J. E., Roback, M. G., Mackenzie, T., & Bothner, J. P. (2000). A randomized, controlled trial of intravenous ketamine and midazolam versus intravenous ketamine alone for pediatric sedation in the emergency department. Annals of Emergency Medicine, 36(6), 579–588. https://doi.org/10.1067/mem.2000.111131
Weiss, M., & Engelhardt, T. (2010). Proposal for the management of the unexpected difficult pediatric airway. Paediatric Anaesthesia, 20(6), 454–464. https://doi.org/10.1111/j.1460-9592.2010.03284.x
Wordliczek, J., Woroń, J., & Serednicki, W. (2015). Analgosedacja i leczenie bólu u dorosłego pacjenta po urazie w warunkach oddziału intensywnej terapii. Anestezjologia i Ratownictwo, 3, 334–344. https://www.akademiamedycyny.pl/wp-content/uploads/2016/05/201503_AiR_011.pdf
Życiński, P., & Miśkowiec, D. (2021). Strategie analgosedacji stosowane podczas zabiegów elektrofizjologicznych – omówienie stosowanych metod – Część 1. Wiadomości Dermatologiczne i Ratownictwo, 1(58), 28–31. https://doi.org/10.5604/01.3001.0015.0107
Downloads
Published
Issue
Section
License
Copyright (c) 2026 Aleksandra Soltys, Katarzyna Anna Borzęcka, Agnieszka Szwed, Daria Aleksandra Warzocha-Żurek, Ewa Maria Polewczak-Karp, Katarzyna Wawrzonek, Krystian Andryszko, Marcelina Dymon, Natalia Ziemba-Furgała, Paulina Krysa

This work is licensed under a Creative Commons Attribution 4.0 International License.
All articles are published in open-access and licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0). Hence, authors retain copyright to the content of the articles.
CC BY 4.0 License allows content to be copied, adapted, displayed, distributed, re-published or otherwise re-used for any purpose including for adaptation and commercial use provided the content is attributed.

