FROM NEUROCHEMISTRY TO REHABILITATION: HOW DOES MUSIC MODIFY THE FUNCTIONING OF THE HUMAN BODY?

Aleksandra Skorupa; Szymon Piosik; Paulina  Pawłowska; Anna Sekunda; Marek Kochański; Natalia  Marko; Gabriela Sępek

doi:10.31435/ijitss.2(50).2026.5499

Authors

Aleksandra Skorupa Medical University of Lublin, Lublin, Poland https://orcid.org/0000-0003-4395-3410
Szymon Piosik Medical University of Lublin, Lublin, Poland https://orcid.org/0009-0003-5142-0275
Paulina Pawłowska Medical University of Lublin, Lublin, Poland https://orcid.org/0009-0008-9340-2864
Anna Sekunda Medical University of Lublin, Lublin, Poland https://orcid.org/0009-0001-9127-6314
Marek Kochański Medical University of Lublin, Lublin, Poland https://orcid.org/0009-0008-0304-8938
Natalia Marko Medical University of Lublin, Lublin, Poland https://orcid.org/0009-0004-7815-4592
Gabriela Sępek Medical University of Lublin, Lublin, Poland https://orcid.org/0009-0009-0308-2981

DOI:

https://doi.org/10.31435/ijitss.2(50).2026.5499

Keywords:

Music Therapy, Dementia, Musical Analgesia, Rehabilitation

Abstract

Background: In light of the rising prevalence of lifestyle diseases, including progressive dementia, chronic pain, and cardiovascular disease, conventional drug therapy frequently entails adverse effects and is often ineffective in enhancing quality of life. Recent advancements in neuroimaging technology, such as functional magnetic resonance imaging (fMRI), have provided substantial evidence to support the notion that music constitutes a potent biological stimulus, capable of inducing significant alterations in brain structures.

Aim: The aim of this article is to present a synthetic overview of current knowledge on the impact of sound stimuli on specific areas of health and to indicate the clinical potential of their regular use in the process of modern rehabilitation.

Materials and Methods: A comprehensive review of the extant scientific literature and meta-analyses, primarily published between 2015 and 2025, was conducted. The analysis encompassed studies which focus on mechanisms such as musical memory preservation in neurodegeneration, non-pharmacological analgesia and the phenomenon of biological rhythm synchronization (entrainment).

Results: Research has demonstrated that in patients diagnosed with Alzheimer's disease, the regions of the brain associated with musical memory exhibit significantly less atrophy compared to those involved in episodic memory. This finding suggests that music can serve as a stabilising "anchor" in communication, thereby reducing anxiety. In the context of pain management, the mechanism of musical analgesia has been substantiated. The activation of descending pain inhibition pathways, concomitant with the release of endogenous opioids, engenders a reduction in analgesic doses. Moreover, research has demonstrated that synchronising the heart rate with the tempo of music facilitates non-pharmacological stabilisation of heart rate and blood pressure

Conclusions: Music has been demonstrated to be a safe and cost-effective method of supporting rehabilitation (Smith, 2020). The impact of regular sound stimulation on the nervous and endocrine systems is quantifiable. It has been demonstrated that such stimulation supports cognitive function in people with dementia and optimises the recovery process by reducing pain and physiological stress.

References

Thaut, M. H., & Hodges, D. A. (Eds.). (2019). The Oxford handbook of music psychology (2nd ed.). Oxford University Press.

Fancourt, D., & Finn, S. (2019). What is the evidence on the role of the arts in improving health and well-being? A scoping review (Health Evidence Network Synthesis Report No. 67). World Health Organization.

Hillecke, T. K., & Wölfl, A. (2023). Scientific foundations of music therapy. Journal of Music Therapy, 60(1), 1–25. https://doi.org/10.1093/jmt/thac017

Ferreri, L., Mas-Herrero, E., Zatorre, R. J., Ripollés, P., Gomez-Andres, A., Alicart, H., Olivé, G., Marco-Pallarés, J., Antonijoan, R. M., Valle, M., Riba, J., & Rodriguez-Fornells, A. (2019). Dopamine modulates the reward experiences elicited by music. Proceedings of the National Academy of Sciences, 116(9), 3793–3798. https://doi.org/10.1073/pnas.1811878116

Keeler, J. R., Roth, E. A., Neuser, B. L., Spitsbergen, J. M., Waters, D. J. M., & Vianney, J.-M. (2015). The neurochemistry and social flow of singing: Bonding and oxytocin. Frontiers in Human Neuroscience, 9, Article 518. https://doi.org/10.3389/fnhum.2015.00518

de Witte, M., Pinho, A. da S., Stams, G.-J. J. M., Moonen, X., Bos, A. E. R., & van Hooren, S. (2020). Music therapy for stress reduction: A systematic review and meta-analysis. Health Psychology Review, 14(4), 525–578. https://doi.org/10.1080/17437199.2019.1627897

Mallik, A., Chanda, M. L., & Levitin, D. J. (2017). Anhedonia to music and mu-opioids: Evidence from the administration of naltrexone. Scientific Reports, 7, Article 41952. https://doi.org/10.1038/srep41952

Kühlmann, A. Y. R., de Rooij, A., Kroese, L. F., van Dijk, M., Hunink, M. G. M., & Jeekel, J. (2018). Meta-analysis evaluating music interventions for anxiety and pain in surgery. British Journal of Surgery, 105(7), 773–783. https://doi.org/10.1002/bjs.10853

Hillecke, T. K., & Wölfl, A. (2023). Scientific foundations of music therapy. Journal of Music Therapy, 60(1), 1–25. https://doi.org/10.1093/jmt/thac017

Jacobsen, J.-H., Stelzer, J., Fritz, T. H., Chételat, G., La Joie, R., & Turner, R. (2015). Why musical memory can be preserved in advanced Alzheimer’s disease. Brain, 138(8), 2438–2450. https://doi.org/10.1093/brain/awv135

Tsoi, K. K. F., Chan, J. Y. C., Ng, Y.-M., Lee, M. M. Y., Kwok, T. C. Y., & Wong, S. Y. S. (2018). Receptive music therapy is more effective than interactive music therapy to relieve behavioral and psychological symptoms of dementia: A systematic review and meta-analysis. Journal of the American Medical Directors Association, 19(7), 568–576.e3. https://doi.org/10.1016/j.jamda.2017.12.009

Leggieri, M., Thaut, M. H., Fornazzari, L., Schweizer, T. A., Barfett, J., Munoz, D. G., & Fischer, C. E. (2019). Music intervention approaches for Alzheimer’s disease: A review of the literature. Frontiers in Neuroscience, 13, Article 132. https://doi.org/10.3389/fnins.2019.00132

van der Steen, J. T., Smaling, H. J. A., van der Wouden, J. C., Bruinsma, M. S., Scholten, R. J. P. M., & Vink, A. C. (2018). Music-based therapeutic interventions for people with dementia. Cochrane Database of Systematic Reviews, 2018(7), Article CD003477. https://doi.org/10.1002/14651858.CD003477.pub4

Garza-Villarreal, E. A., Pando, V., Vuust, P., & Parsons, C. (2017). Music-induced analgesia in chronic pain conditions: A systematic review and meta-analysis. Pain Physician, 20(7), 597–610.

Hole, J., Hirsch, M., Ball, E., & Meads, C. (2015). Music as an aid for postoperative recovery in adults: A systematic review and meta-analysis. The Lancet, 386(10004), 1659–1671. https://doi.org/10.1016/S0140-6736(15)60169-6

Hillecke, T. K., & Wölfl, A. (2023). Scientific foundations of music therapy. Journal of Music Therapy, 60(1), 1–25. https://doi.org/10.1093/jmt/thac017

Innes, K. E., Selfe, T. K., Brundage, K., Montgomery, C., Wen, S., Kandati, S., & Huysmans, Z. (2018). Effects of meditation and music-listening on blood biomarkers of cellular aging and Alzheimer’s disease: An exploratory randomized controlled trial. Journal of Alzheimer’s Disease, 66(3), 947–970. https://doi.org/10.3233/JAD-180164

Koelsch, S., & Jäncke, L. (2015). Music and the heart. European Heart Journal, 36(44), 3043–3049. https://doi.org/10.1093/eurheartj/ehv430

Clements-Cortés, A., & Bartel, L. (2018). Vibroacoustic sound therapy: Case studies with children with sensory processing disorder and autism. Music and Medicine, 10(1), 31–37.

Ray, K. D., & Götell, E. (2018). The use of music and music therapy in ameliorating depression symptoms and improving well-being in nursing home residents with dementia. Frontiers in Medicine, 5, Article 287. https://doi.org/10.3389/fmed.2018.00287

Bradt, J., Dileo, C., Myers-Coffman, K., & Biondo, J. (2021). Music interventions for improving psychological and physical outcomes in people with cancer. Cochrane Database of Systematic Reviews, 2021(10), Article CD006911. https://doi.org/10.1002/14651858.CD006911.pub4

Madden, A. D., Mölders, K., & White, M. (2020). Music listening and pain perception: A systematic review. Psychology of Music, 48(6), 842–859.

Bernardi, L., Porta, C., Casucci, G., Casiraghi, N., Spicuzza, L., & Sleight, P. (2017). Cardiovascular and respiratory responses to music. In S. Hallam, I. Cross, & M. Thaut (Eds.), The Oxford handbook of music psychology (2nd ed.). Oxford University Press.