3D-PRINTED AND PERSONALIZED ORTHOPEDIC IMPLANTS: FUNCTIONAL OUTCOMES AND RETURN TO SPORT – A STRUCTURED REVIEW
DOI:
https://doi.org/10.31435/ijitss.2(50).2026.5585Keywords:
3D Printing, Additive Manufacturing, Patient-Specific Implants, Personalized Arthroplasty, Kinematic Alignment, Restricted Kinematic Alignment, Functional Outcomes, Return to Sport, Orthopedic ImplantsAbstract
Background: Conventional orthopedic implants are standardized and may not fully reflect individual anatomical variability and biomechanics, particularly in physically active patients. Advances in additive manufacturing (3D printing) and personalized alignment strategies have enabled the development of patient-specific solutions aimed at improving functional outcomes.
Aim: To evaluate the effectiveness of 3D-printed and personalized orthopedic implants in improving functional outcomes and facilitating return to sport.
Methods: A structured review of 31 studies identified through PubMed, Scopus, and Google Scholar was conducted. The analysis included knee and hip procedures utilizing additive manufacturing, patient-specific instrumentation, and alignment strategies such as kinematic alignment (KA) and restricted kinematic alignment (rKA). Outcomes included patient-reported measures (KOOS, Forgotten Joint Score, WOMAC), implant survivorship, complication rates, and return-to-sport (RTS).
Results: Personalized approaches demonstrated comparable or superior functional outcomes compared to conventional techniques. Improvements in KOOS Sport and Forgotten Joint Scores were reported in knee procedures. In total knee arthroplasty, rKA showed high survivorship (up to 98%) and favorable functional outcomes. RTS rates ranged from 70% to 100%, with a shift toward low-impact activities. In hip arthroplasty, personalized planning and advanced materials improved implant performance without increasing complication rates. Overall, complication rates remained low and comparable to standard approaches.
Conclusions: 3D-printed and personalized implants represent a safe and effective advancement in orthopedic care, improving function and supporting return to physical activity. Further high-quality, long-term studies are needed to confirm durability, cost-effectiveness, and broader applicability.
References
Lustig, S., Sappey-Marinier, E., Fary, C., Servien, E., Parratte, S., & Batailler, C. (2021). Personalized alignment in total knee arthroplasty: Current concepts. SICOT-J, 7, Article 19. https://doi.org/10.1051/sicotj/2021021
Andriollo, L., Picchi, A., Iademarco, G., Fidanza, A., Perticarini, L., Rossi, S. M. P., Logroscino, G., & Benazzo, F. (2025). The role of artificial intelligence and emerging technologies in advancing total hip arthroplasty. Journal of Personalized Medicine, 15(1), Article 21. https://doi.org/10.3390/jpm15010021
Preston, B., Harris, S., Villet, L., Mattathil, C., Cobb, J., & Rivière, C. (2022). The medial condylar wall is a reliable landmark to kinematically align the femoral component in medial UKA: An in-silico study. Knee Surgery, Sports Traumatology, Arthroscopy, 30(9), 3220–3227. https://doi.org/10.1007/s00167-021-06683-9
Vendittoli, P. A., Riviere, C., Hirschmann, M. T., & Bini, S. (2023). Why personalized surgery is the future of hip and knee arthroplasty: A statement from the Personalized Arthroplasty Society. EFORT Open Reviews, 8(12), 874–882. https://doi.org/10.1530/EOR-22-0096
Rivière, C., Jackson, W., Villet, L., Sivaloganathan, S., Barziv, Y., & Vendittoli, P. A. (2021). Specific case consideration for implanting TKA with the kinematic alignment technique. EFORT Open Reviews, 6(10), 881–891. https://doi.org/10.1302/2058-5241.6.210042
Zhang, Z., Li, W., Song, B., Wang, S., & Shou, K. (2025). A controlled study of personalized versus standard osteotomy in medial unicompartmental knee osteoarthritis. Journal of Orthopaedic Surgery and Research, 20(1), Article 344. https://doi.org/10.1186/s13018-025-05728-w
Rivière, C., Sivaloganathan, S., Villet, L., Cartier, P., Lustig, S., Vendittoli, P. A., & Cobb, J. (2022). Kinematic alignment of medial UKA is safe: A systematic review. Knee Surgery, Sports Traumatology, Arthroscopy, 30(3), 1082–1094. https://doi.org/10.1007/s00167-021-06462-6
Selley, R., Itthipanichpong, T., Menta, S. V., & Ranawat, A. S. (2023). Osteochondral allograft and high tibial osteotomy with patient-specific instrumentation. Video Journal of Sports Medicine, 3(4), Article 26350254231186435. https://doi.org/10.1177/26350254231186435
Frossard, L., Langton, C., Perevoshchikova, N., Feih, S., Powrie, R., Barrett, R., & Lloyd, D. (2023). Next-generation devices to diagnose residuum health of individuals suffering from limb loss: A narrative review of trends, opportunities, and challenges. Journal of Science and Medicine in Sport, 26(Suppl. 1), S22–S29. https://doi.org/10.1016/j.jsams.2023.02.004
Haneberg, E., Phillips, A., Wright-Chisem, J., & Yanke, A. (2025). Patient-specific custom patellofemoral arthroplasty. Video Journal of Sports Medicine, 5(4), Article 26350254241307241. https://doi.org/10.1177/26350254241307241
Xu, G., Wang, Q., Li, Z., & Wu, T. (2023). Computed tomography osteoabsorptiometry: Review of bone density, mechanical strength of material and clinical application. Frontiers in Bioengineering and Biotechnology, 11, Article 1066709. https://doi.org/10.3389/fbioe.2023.1066709
Chen, Y., Hao, M., Bousso, I., Thomopoulos, S., & Xia, Y. (2024). Reliable fabrication of mineral-graded scaffolds by spin-coating and laser machining for use in tendon-to-bone insertion repair. Advanced Healthcare Materials, 13(31), Article e2402531. https://doi.org/10.1002/adhm.202402531
Sankova, M. V., Beeraka, N. M., Oganesyan, M. V., Rizaeva, N. A., Sankov, A. V., Shelestova, O. S., Bulygin, K. V., Vikram Pr, H., Barinov, A. N., Khalimova, A. K., Padmanabha Reddy, Y., Basappa, B., & Nikolenko, V. N. (2024). Recent developments in Achilles tendon risk-analyzing rupture factors for enhanced injury prevention and clinical guidance: Current implications of regenerative medicine. Journal of Orthopaedic Translation, 49, 289–307. https://doi.org/10.1016/j.jot.2024.08.024
Lavigne, M., Vendittoli, P. A., Virolainen, P., Corten, K., Martinez, M., Zicat, B., Peter, V., Bloem, R., Miazzolo, N., & Remes, V. (2020). Large head ceramic-on-ceramic bearing in primary total hip arthroplasty: Average 3-year follow-up of a multicentre study. Hip International, 30(6), 711–717. https://doi.org/10.1177/1120700019863376
Blakeney, W. G., Beaulieu, Y., Puliero, B., Lavigne, M., Roy, A., Massé, V., & Vendittoli, P. A. (2018). Excellent results of large-diameter ceramic-on-ceramic bearings in total hip arthroplasty: Is squeaking related to head size? The Bone & Joint Journal, 100-B(11), 1434–1441. https://doi.org/10.1302/0301-620X.100B11.BJJ-2018-0532.R1
Bragdon, C. R., Doerner, M., Martell, J., Jarrett, B., Palm, H., Multicenter Study Group, & Malchau, H. (2013). The 2012 John Charnley Award: Clinical multicenter studies of the wear performance of highly crosslinked remelted polyethylene in THA. Clinical Orthopaedics and Related Research, 471(2), 393–402. https://doi.org/10.1007/s11999-012-2604-0
Saikko, V. (2019). Wear and friction of thin, large-diameter acetabular liners made from highly cross-linked, vitamin-E-stabilized UHMWPE against CoCr femoral heads. Wear, 432–433, Article 202948. https://doi.org/10.1016/j.wear.2019.202948
Lopez-Hualda, A., García-Cabrera, E. M., Lobato-Perez, M., Martinez-Martin, J., Rossettini, G., Leigheb, M., & Villafañe, J. H. (2024). Mechanical complications of proximal femur fractures treated with intramedullary nailing: A retrospective study. Medicina, 60(5), Article 718. https://doi.org/10.3390/medicina60050718
Parker, M. J., & Handoll, H. H. (2010). Gamma and other cephalocondylic intramedullary nails versus extramedullary implants for extracapsular hip fractures in adults. Cochrane Database of Systematic Reviews, 2010(9), Article CD000093. https://doi.org/10.1002/14651858.CD000093.pub5
Brunner, A., Büttler, M., Lehmann, U., Frei, H. C., Kratter, R., Di Lazzaro, M., Scola, A., Sermon, A., & Attal, R. (2016). What is the optimal salvage procedure for cut-out after surgical fixation of trochanteric fractures with the PFNA or TFN? A multicentre study. Injury, 47(2), 432–438. https://doi.org/10.1016/j.injury.2015.11.027
Baldari, A., Saccone, L., Caldaria, A., de Sanctis, E. G., De Angelis D’Ossat, G. M., La Verde, L., Palumbo, A., & Franceschi, F. (2024). Revision shoulder arthroplasty and proximal humeral bone loss: A comprehensive review and proposal of a new algorithm of management. Journal of Orthopaedics and Traumatology, 25(1), Article 40. https://doi.org/10.1186/s10195-024-00784-0
Rivière, C., & Vendittoli, P.-A. (2020). Personalized hip and knee joint replacement. Springer Nature.
Mosesian, L., Derian, J. M., Shifflett, G. D., & Lantz, J. M. (2025). Postoperative physical therapy for cervical total disc replacement: A case report. International Journal of Sports Physical Therapy, 20(6), 842–854. https://doi.org/10.26603/001c.137694
Filardo, G., Andriolo, L., Angele, P., Berruto, M., Brittberg, M., Condello, V., Chubinskaya, S., de Girolamo, L., Di Martino, A., Di Matteo, B., Gille, J., Gobbi, A., Lattermann, C., Nakamura, N., Nehrer, S., Peretti, G. M., Shabshin, N., Verdonk, P., Zaslav, K., & Kon, E. (2021). Scaffolds for knee chondral and osteochondral defects: Indications for different clinical scenarios. A consensus statement. Cartilage, 13(1_suppl), 1036S–1046S. https://doi.org/10.1177/1947603519894729
Arteaga, J., Poblete, E., Martin, F., Domecq, G., & Figueroa, D. (2025). Return to sports and recreational activities after patellofemoral arthroplasty: A systematic review. Journal of ISAKOS, 14, Article 100925. https://doi.org/10.1016/j.jisako.2025.100925
Clegg, B. A., Perry, S., De Pieri, E., Redmond, A. C., Ferguson, S. J., Lunn, D. E., Hall, R. M., Bryant, M. G., Emami, N., & Beadling, A. R. (2025). Effects of physiological loading from patient-derived activities of daily living on the wear of metal-on-polymer total hip replacements. Bioengineering, 12(6), Article 663. https://doi.org/10.3390/bioengineering12060663
Sonntag, R., Braun, S., Al-Salehi, L., Reinders, J., Mueller, U., & Kretzer, J. P. (2017). Three-dimensional friction measurement during hip simulation. PLOS ONE, 12(9), Article e0184043. https://doi.org/10.1371/journal.pone.0184043
Pontoh, L. A. P., Dilogo, I. H., Fiolin, J., Gosal, S., Herdiman, J. A., Hawali, A. A., & Kholinne, E. (2026). Application of artificial intelligence in orthopaedic research: From preclinical to translational. Journal of Orthopaedic Surgery, 34(1), Article 10225536261424029. https://doi.org/10.1177/10225536261424029
Craig, B. M., Reeve, B. B., Brown, P. M., Cella, D., Hays, R. D., Lipscomb, J., Pickard, A. S., & Revicki, D. A. (2014). US valuation of health outcomes measured using the PROMIS-29. Value in Health, 17(8), 846–853. https://doi.org/10.1016/j.jval.2014.09.005
Tan, J. M., Halford, G. R. J., Lukin, M., & Kohler, F. (2023). Recommendations from the ISPO lower-limb COMPASS: Patient-reported and performance-based outcome measures. Prosthetics and Orthotics International, 47(1), 13–25. https://doi.org/10.1097/PXR.0000000000000197
Vermue, H., Mesnard, G., Servien, E., Batailler, C., & Lustig, S. (2025). Rotating-platform deep-dish total knee arthroplasty with restricted kinematic alignment: Five-year clinical and functional outcomes. SICOT-J, 11, Article 33. https://doi.org/10.1051/sicotj/2025018
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Copyright (c) 2026 Sebastian Podeszwa, Wiktor Rolski, Zuzanna Przybylska, Paulina Michalska, Bartłomiej Przystaś, Magdalena Grzechowiak, Aleksandra Anna Purpura, Mikołaj Piotr Hobot, Gabriela Patrycja Dobosz

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