ANTI-INFLAMMATORY DIETARY PATTERNS IN ENDOMETRIOSIS: MECHANISMS, CLINICAL EVIDENCE, AND PERSPECTIVES FOR FUTURE RESEARCH

Kamila Zioło; Weronika  Zarzycka; Jakub  Skrzypek; Natalia Fidut; Karol  Szyprowski; Maciej  Kisielewski; Julia  Wawerska; Weronika  Wrzosek; Mateusz  Zugaj; Bartosz  Okliński

doi:10.31435/ijitss.2(50).2026.5695

Authors

Kamila Zioło 1st Military Clinical Hospital with the Outpatient Clinic, Lublin, Poland https://orcid.org/0009-0003-3875-4000
Weronika Zarzycka 1st Military Clinical Hospital with the Outpatient Clinic, Lublin, Poland https://orcid.org/0009-0004-1927-4076
Jakub Skrzypek Stefan Cardinal Wyszyński Provincial Specialist Hospital SPZOZ in Lublin, Lublin, Poland https://orcid.org/0009-0004-1155-5818
Natalia Fidut Stefan Cardinal Wyszyński Provincial Specialist Hospital SPZOZ in Lublin, Lublin, Poland https://orcid.org/0009-0006-2550-3933
Karol Szyprowski 1st Military Clinical Hospital with the Outpatient Clinic, Lublin, Poland https://orcid.org/0009-0001-0336-6425
Maciej Kisielewski Stefan Cardinal Wyszyński Provincial Specialist Hospital SPZOZ in Lublin, Lublin, Poland https://orcid.org/0009-0003-1797-9155
Julia Wawerska Medical University of Lodz, Łódź, Poland https://orcid.org/0009-0006-0145-6204
Weronika Wrzosek University Clinical Hospital No. 1 in Lublin, Lublin, Poland https://orcid.org/0009-0002-6680-5760
Mateusz Zugaj Stefan Cardinal Wyszyński Provincial Specialist Hospital SPZOZ in Lublin, Lublin, Poland https://orcid.org/0009-0000-2848-6952
Bartosz Okliński Stefan Cardinal Wyszyński Provincial Specialist Hospital SPZOZ in Lublin, Lublin, Poland https://orcid.org/0009-0003-9018-6784

DOI:

https://doi.org/10.31435/ijitss.2(50).2026.5695

Keywords:

Endometriosis, Anti-Inflammatory Diet, Mediterranean Diet, Omega-3 Fatty AIDS, Estrogen Metabolizm, Inflammation, Gut Microbiome, Dysmenorrhea

Abstract

Purpose: The aim of this article was to provide an in-depth review of the current literature and research on the role of anti-inflammatory dietary patterns in the treatment of endometriosis.

Methodology: A thorough and extensive review of the literature was conducted using various scientific databases, such as PubMed, Google Scholar and Scopus. During the selection process, particular attention was paid to clinical trials, systematic reviews and meta-analyses concerning dietary patterns, specific nutrients and bioactive anti-inflammatory compounds in relation to the risk, severity of symptoms and progression of endometriosis.

Findings: Evidence indicates that anti-inflammatory diets may help manage endometriosis symptoms. However, the few available clinical studies are varied and often low in quality. There is also a lack of long-term randomized controlled trials with standardized protocols and biomarker endpoints, making it difficult to confirm causality or create clinical guidelines.

Conclusion: Anti-inflammatory diets may help reduce endometriosis symptoms by lowering inflammation, affecting oestrogen metabolism, and regulating the gut microbiome—factors central to disease progression. While observational studies and small trials suggest benefits from diets rich in whole foods and low in red meat and trans fats, more advanced clinical trials are needed. The authors highlight the importance of further research using biomarkers and personalized nutrition to create evidence-based dietary guidelines. Future studies should assess diet alongside inflammation, hormone, and microbiome profiles to support tailored nutritional strategies for endometriosis treatment.

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