NON-INVASIVE VENTILATION IN CARDIAC PULMONARY EDEMA – NARRATIVE REVIEW

Authors

DOI:

https://doi.org/10.31435/ijitss.2(50).2026.5832

Keywords:

Cardiogenic Pulmonary Edema; Non-Invasive Ventilation; Acute Respiratory Failure; Heart Failure; CPAP; BiPAP; Emergency Care

Abstract

Non-invasive ventilation (NIV), including continuous positive airway pressure (CPAP) and bilevel positive airway pressure (BiPAP), is a cornerstone in the management of acute cardiogenic pulmonary edema (CPE). NIV improves oxygenation, reduces the work of breathing, and exerts favorable hemodynamic effects by decreasing preload and afterload. These physiological mechanisms contribute to rapid clinical stabilization in critically ill patients.

Current estimates suggest that the condition affects approximately 1 million patients with pulmonary edema secondary to cardiac causes. (1) Patients with CPE present with a wide range of symptoms, most notably dyspnea, reflecting the acute nature of the condition, underscoring the severity and clinical importance of the issue.

Overall, NIV represents an effective first-line supportive therapy in patients with acute CPE, although further research is needed to clarify its effect on long-term outcomes. Available data consistently demonstrate that NIV reduces the need for endotracheal intubation and improves short-term physiological parameters, particularly when initiated early. (2) However, its impact on mortality remains inconsistent across studies.

This review synthesizes current evidence on NIV in cardiogenic pulmonary edema, focusing on underlying mechanisms, clinical effectiveness, and comparative data on CPAP and BiPAP, with emphasis on their role in emergency and intensive care settings.

References

Pilgrim, A. (2023). Acute pulmonary edema and NSTEMI. Journal of Education & Teaching in Emergency Medicine, 8(3), O1–O32. https://doi.org/10.21980/J8CW67

Plaisance, P., Pirracchio, R., Berton, C., Vicaut, E., & Payen, D. (2007). A randomized study of out-of-hospital continuous positive airway pressure for acute cardiogenic pulmonary oedema: Physiological and clinical effects. European Heart Journal, 28(23), 2895–2901. https://doi.org/10.1093/eurheartj/ehm502

Walkey, A. J., & Wiener, R. S. (2013). Use of noninvasive ventilation in patients with acute respiratory failure, 2000–2009: A population-based study. Annals of the American Thoracic Society, 10(1), 10–17. https://doi.org/10.1513/AnnalsATS.201206-034OC

Bello, G., De Santis, P., & Antonelli, M. (2018). Non-invasive ventilation in cardiogenic pulmonary edema. Annals of Translational Medicine, 6(18), 355. https://doi.org/10.21037/atm.2018.04.39

Malek, R., & Soufi, S. (2023). Pulmonary edema. In StatPearls. StatPearls Publishing.

Sisakian, H. S., & Tavaratsyan, A. R. (2024). Cardiogenic pulmonary edema—is it lone cardiogenic? “Missing link” between hemodynamic and other existing mechanisms. American Journal of Cardiovascular Disease, 14(2), 81–89. https://doi.org/10.62347/YGQQ8696

Zanza, C., Saglietti, F., Tesauro, M., Longhitano, Y., Savioli, G., Balzanelli, M. G., Romenskaya, T., Cofone, L., Pindinello, I., Racca, G., & Racca, F. (2023). Cardiogenic pulmonary edema in emergency medicine. Advances in Respiratory Medicine, 91(5), 445–463. https://doi.org/10.3390/arm91050034

Tetaj, N., Capecchi, G., Rubino, D., Stazi, G. V., Cingolani, E., Lesci, A., Segreti, A., Grigioni, F., & Bocci, M. G. (2026). Respiratory support in cardiogenic pulmonary edema: Clinical insights from cardiology and intensive care. Journal of Cardiovascular Development and Disease, 13(1), 54. https://doi.org/10.3390/jcdd13010054

Iqbal, M. A., & Gupta, M. (2023). Cardiogenic pulmonary edema. In StatPearls. StatPearls Publishing.

Mebazaa, A., Yilmaz, M. B., Levy, P., Ponikowski, P., Peacock, W. F., Laribi, S., Ristic, A. D., Lambrinou, E., Masip, J., Riley, J. P., McDonagh, T., Mueller, C., deFilippi, C., Harjola, V. P., Thiele, H., Piepoli, M. F., Metra, M., Maggioni, A., McMurray, J., ... Filippatos, G. (2015). Recommendations on pre-hospital and early hospital management of acute heart failure: A consensus paper from the Heart Failure Association of the European Society of Cardiology, the European Society of Emergency Medicine and the Society of Academic Emergency Medicine. European Journal of Heart Failure, 17(6), 544–558. https://doi.org/10.1002/ejhf.289

McDonagh, T. A., Metra, M., Adamo, M., Gardner, R. S., Baumbach, A., Böhm, M., Burri, H., Butler, J., Čelutkienė, J., Chioncel, O., Cleland, J. G. F., Coats, A. J. S., Crespo-Leiro, M. G., Farmakis, D., Gilard, M., Heymans, S., Hoes, A. W., Jaarsma, T., Jankowska, E. A., ... ESC Scientific Document Group. (2022). 2021 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure: Developed by the Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC), with the special contribution of the Heart Failure Association (HFA) of the ESC. European Journal of Heart Failure, 24(1), 4–131. https://doi.org/10.1002/ejhf.2333

Domínguez-Rodríguez, A., Suero-Mendez, C., Burillo-Putze, G., Gil, V., Calvo-Rodriguez, R., Piñera-Salmeron, P., Llorens, P., Martín-Sánchez, F. J., Abreu-Gonzalez, P., Miró, Ò., & MIMO (MIdazolam Versus MOrphine) Trial Investigators. (2022). Midazolam versus morphine in acute cardiogenic pulmonary oedema: Results of a multicentre, open-label, randomized controlled trial. European Journal of Heart Failure, 24(10), 1953–1962. https://doi.org/10.1002/ejhf.2602

Bersten, A. D., Holt, A. W., Vedig, A. E., Skowronski, G. A., & Baggoley, C. J. (1991). Treatment of severe cardiogenic pulmonary edema with continuous positive airway pressure delivered by face mask. The New England Journal of Medicine, 325(26), 1825–1830. https://doi.org/10.1056/NEJM199112263252601

Gray, A., Goodacre, S., Newby, D. E., Masson, M., Sampson, F., Nicholl, J., & 3CPO Trialists. (2008). Noninvasive ventilation in acute cardiogenic pulmonary edema. The New England Journal of Medicine, 359(2), 142–151. https://doi.org/10.1056/NEJMoa0707992

Chadda, K., Annane, D., Hart, N., Gajdos, P., Raphaël, J. C., & Lofaso, F. (2002). Cardiac and respiratory effects of continuous positive airway pressure and noninvasive ventilation in acute cardiac pulmonary edema. Critical Care Medicine, 30(11), 2457–2461. https://doi.org/10.1097/00003246-200211000-00009

Berbenetz, N., Wang, Y., Brown, J., Godfrey, C., Ahmad, M., Vital, F. M., Lambiase, P., Banerjee, A., Bakhai, A., & Chong, M. (2019). Non-invasive positive pressure ventilation (CPAP or bilevel NPPV) for cardiogenic pulmonary oedema. The Cochrane Database of Systematic Reviews, 4(4), CD005351. https://doi.org/10.1002/14651858.CD005351.pub4

Popowicz, P., & Leonard, K. (2022). Noninvasive ventilation and oxygenation strategies. The Surgical Clinics of North America, 102(1), 149–157. https://doi.org/10.1016/j.suc.2021.09.012

Vital, F. M., Ladeira, M. T., & Atallah, A. N. (2013). Non-invasive positive pressure ventilation (CPAP or bilevel NPPV) for cardiogenic pulmonary oedema. The Cochrane Database of Systematic Reviews, 2013(5), CD005351. https://doi.org/10.1002/14651858.CD005351.pub3

Rezoagli, E., Nova, A., Carteaux, G., Giani, M., Grieco, D. L., Pettenuzzo, T., Lucchini, A., Navalesi, P., Antonelli, M., Foti, G., Bellani, G., & Piquilloud, L. (2025). A clinical guide to non-invasive respiratory support in acute respiratory failure: Ventilation settings, technical optimization and clinical indications. Critical Care, 29(1), 496. https://doi.org/10.1186/s13054-025-05730-y

Frat, J. P., Grieco, D. L., De Jong, A., Gibbs, K., Carteaux, G., Roca, O., Lemiale, V., Piquilloud, L., Rittayamai, N., Pisani, L., Hernandez, G., & Thille, A. W. (2025). Noninvasive respiratory supports in ICU. Intensive Care Medicine, 51(8), 1476–1489. https://doi.org/10.1007/s00134-025-08036-3

Thompson, J., Petrie, D. A., Ackroyd-Stolarz, S., & Bardua, D. J. (2008). Out-of-hospital continuous positive airway pressure ventilation versus usual care in acute respiratory failure: A randomized controlled trial. Annals of Emergency Medicine, 52(3), 232–241.e1. https://doi.org/10.1016/j.annemergmed.2008.01.006

Masip, J., Roque, M., Sánchez, B., Fernández, R., Subirana, M., & Expósito, J. A. (2005). Noninvasive ventilation in acute cardiogenic pulmonary edema: Systematic review and meta-analysis. JAMA, 294(24), 3124–3130. https://doi.org/10.1001/jama.294.24.3124

Roessler, M. S., Schmid, D. S., Michels, P., Schmid, O., Jung, K., Stöber, J., Neumann, P., Quintel, M., & Moerer, O. (2012). Early out-of-hospital non-invasive ventilation is superior to standard medical treatment in patients with acute respiratory failure: A pilot study. Emergency Medicine Journal, 29(5), 409–414. https://doi.org/10.1136/emj.2010.106393

Park, M., Sangean, M. C., Volpe, M. de S., Feltrim, M. I., Nozawa, E., Leite, P. F., Passos Amato, M. B., & Lorenzi-Filho, G. (2004). Randomized, prospective trial of oxygen, continuous positive airway pressure, and bilevel positive airway pressure by face mask in acute cardiogenic pulmonary edema. Critical Care Medicine, 32(12), 2407–2415. https://doi.org/10.1097/01.ccm.0000147770.20400.10

Kallio, T., Kuisma, M., Alaspää, A., & Rosenberg, P. H. (2003). The use of prehospital continuous positive airway pressure treatment in presumed acute severe pulmonary edema. Prehospital Emergency Care, 7(2), 209–213. https://doi.org/10.1080/10903120390936798

Schnell, D., Timsit, J. F., Darmon, M., Vesin, A., Goldgran-Toledano, D., Dumenil, A. S., Garrouste-Orgeas, M., Adrie, C., Bouadma, L., Planquette, B., Cohen, Y., Schwebel, C., Soufir, L., Jamali, S., Souweine, B., & Azoulay, E. (2014). Noninvasive mechanical ventilation in acute respiratory failure: Trends in use and outcomes. Intensive Care Medicine, 40(4), 582–591. https://doi.org/10.1007/s00134-014-3222-y

Ferrer, M., Valencia, M., Nicolas, J. M., Bernadich, O., Badia, J. R., & Torres, A. (2006). Early noninvasive ventilation averts extubation failure in patients at risk: A randomized trial. American Journal of Respiratory and Critical Care Medicine, 173(2), 164–170. https://doi.org/10.1164/rccm.200505-718OC

Rochwerg, B., Brochard, L., Elliott, M. W., Hess, D., Hill, N. S., Nava, S., Navalesi, P., Members of the Steering Committee, Antonelli, M., Brozek, J., Conti, G., Ferrer, M., Guntupalli, K., Jaber, S., Keenan, S., Mancebo, J., Mehta, S., & Raoof, S., Members of the Task Force. (2017). Official ERS/ATS clinical practice guidelines: Noninvasive ventilation for acute respiratory failure. The European Respiratory Journal, 50(2), 1602426. https://doi.org/10.1183/13993003.02426-2016

Garuti, G., Bandiera, G., Cattaruzza, M. S., Gelati, L., Osborn, J. F., Toscani, S., Confalonieri, M., & Lusuardi, M. (2010). Out-of-hospital helmet CPAP in acute respiratory failure reduces mortality: A study led by nurses. Monaldi Archives for Chest Disease, 73(4), 145–151. https://doi.org/10.4081/monaldi.2010.283

Downloads

Published

2026-06-29

How to Cite

Szubert, I., Suchecka, J., Lamorski, J., Stępień, G. ., Nesterak, W., Chylewski, M., Chudecka, K., Kędzierska, A., Przewoźna, U., & Józwa, K. (2026). NON-INVASIVE VENTILATION IN CARDIAC PULMONARY EDEMA – NARRATIVE REVIEW. International Journal of Innovative Technologies in Social Science, 3(2(50). https://doi.org/10.31435/ijitss.2(50).2026.5832

Most read articles by the same author(s)