LIFESTYLE MEDICINE AND THE PREVENTION OF DEPRESSION: SOCIAL DETERMINANTS, DIGITAL INTERVENTIONS, AND PUBLIC HEALTH IMPLICATIONS
DOI:
https://doi.org/10.31435/ijitss.3(51).2026.5833Keywords:
Depression, Lifestyle Medicine, Public Health, Social Determinants of Health, Digital Health, PreventionAbstract
Background: Depression is one of the leading causes of disability worldwide, with increasing prevalence and significant socioeconomic burden. While pharmacological and psychotherapeutic treatments are well established, preventive strategies remain underdeveloped.
Objective: This review aims to evaluate the role of lifestyle medicine interventions—including physical activity, diet, sleep, and stress management—in the prevention of depression, with a focus on social determinants and implementation challenges.
Methods: A narrative review of recent literature (primarily from the last 10 years) was conducted, focusing on studies examining associations between lifestyle factors and depression risk, as well as public health and socioeconomic aspects.
Results: Evidence suggests that regular physical activity, healthy dietary patterns, adequate sleep, and stress reduction strategies are associated with a lower risk of depression. However, significant barriers limit the large-scale implementation of these interventions, including socioeconomic inequalities, lack of healthcare system integration, and low patient adherence. Digital health tools and social determinants significantly influence the accessibility and effectiveness of lifestyle interventions.
Conclusions: Lifestyle medicine represents a promising, cost-effective strategy for depression prevention. Future efforts should focus on integrating these approaches into public health policies and addressing social disparities to improve accessibility and effectiveness. Integrating digital health solutions and addressing social inequalities is essential for effective prevention strategies.
References
Firth, J., Solmi, M., Wootton, R. E., et al. (2020). A meta-review of “lifestyle psychiatry”: The role of exercise, smoking, diet and sleep in the prevention and treatment of mental disorders. World Psychiatry, 19(3), 360–380. https://doi.org/10.1002/wps.20773
Pearce, M., Garcia, L., Abbas, A., et al. (2022). Association between physical activity and risk of depression: A systematic review and meta-analysis. JAMA Psychiatry, 79(6), 550–559. https://doi.org/10.1001/jamapsychiatry.2022.0609
Choi, K. W., Chen, C. Y., Stein, M. B., et al. (2019). Assessment of bidirectional relationships between physical activity and depression among adults. JAMA Psychiatry, 76(4), 399–408. https://doi.org/10.1001/jamapsychiatry.2018.4175
Singh, B., Olds, T., Curtis, R., et al. (2023). Effectiveness of physical activity interventions for preventing depression: Umbrella review of meta-analyses. Br J Sports Med, 57(18), 1203–1209. https://doi.org/10.1136/bjsports-2022-106195
Harvey, S. B., Øverland, S., Hatch, S. L., et al. (2018). Exercise and the prevention of depression: Results of the HUNT cohort study. Am J Psychiatry, 175(1), 28–36. https://doi.org/10.1176/appi.ajp.2017.16111223
Lassale, C., Batty, G. D., Baghdadli, A., et al. (2019). Healthy dietary indices and risk of depressive outcomes: A systematic review and meta-analysis. Mol Psychiatry, 24(7), 965–986. https://doi.org/10.1038/s41380-018-0237-8
Firth, J., Gangwisch, J. E., Borisini, A., et al. (2020). Food and mood: How diet and nutrition affect mental health. BMJ, 369, m2382. https://doi.org/10.1136/bmj.m2382
Adan, R. A. H., van der Beek, E. M., Buitelaar, J. K., et al. (2019). Nutritional psychiatry: Towards improving mental health by what you eat. Eur Neuropsychopharmacol, 29(12), 1321–1332. https://doi.org/10.1016/j.euroneuro.2019.10.011
Marx, W., Moseley, G., Berk, M., & Jacka, F. (2021). Nutritional psychiatry: The present state of the evidence. Proc Nutr Soc, 80(1), 29–39. https://doi.org/10.1017/S0029665120004038
Jacka, F. N., O’Neil, A., Opie, R., et al. (2017). A randomised controlled trial of dietary improvement for adults with major depression (SMILES trial). BMC Med, 15, 23. https://doi.org/10.1186/s12916-017-0791-y
O’Neil, A., Quirk, S. E., Housden, S., et al. (2014). Relationship between diet and mental health in children and adolescents: A systematic review. Am J Public Health, 104(10), e31–e42. https://doi.org/10.2105/AJPH.2014.302110
Li, L., Wu, C., Gan, Y., et al. (2019). Insomnia and the risk of depression: A meta-analysis of prospective cohort studies. BMC Psychiatry, 19, 375. https://doi.org/10.1186/s12888-019-2350-0
Fang, H., Tu, S., Sheng, J., & Shao, A. (2019). Depression in sleep disturbance: A review on a bidirectional relationship. Front Psychiatry, 10, 811. https://doi.org/10.3389/fpsyt.2019.00811
Baglioni, C., Battagliese, G., Feige, B., et al. (2011). Insomnia as a predictor of depression: A meta-analytic evaluation of longitudinal studies. J Affect Disord, 135(1–3), 10–19. https://doi.org/10.1016/j.jad.2011.01.011
Freeman, D., Sheaves, B., Waite, F., et al. (2020). Sleep disturbance and psychiatric disorders. Lancet Psychiatry, 7(7), 628–637. https://doi.org/10.1016/S2215-0366(20)30136-X
Hammen, C. (2018). Stress and depression: Old questions, new approaches. Curr Opin Psychol, 4, 80–85. https://doi.org/10.1016/j.copsyc.2018.02.012
Slavich, G. M. (2020). Psychoneuroimmunology of stress and depression: Immune mechanisms. Annu Rev Clin Psychol, 16, 265–295. https://doi.org/10.1146/annurev-clinpsy-050718-095552
McEwen, B. S., & Akil, H. (2020). Revisiting the stress concept: Implications for affective disorders. J Neurosci, 40(1), 12–21. https://doi.org/10.1523/JNEUROSCI.0737-19.2019
Goldberg, S. B., Tucker, R. P., Greene, P. A., et al. (2018). Mindfulness-based interventions for psychiatric disorders: A systematic review and meta-analysis. Clin Psychol Rev, 59, 52–60. https://doi.org/10.1016/j.cpr.2017.10.011
Bizzozero-Peroni, B., Díaz-Goñi, V., Jiménez-López, E., et al. (2024). Daily step count and depression in adults: A systematic review and meta-analysis. JAMA Netw Open, 7(12), e2451208. https://doi.org/10.1001/jamanetworkopen.2024.51208
Huang, X., Chen, Z., Xu, Z., Liu, X., Lv, Y., & Yu, L. (2025). The relationship between physical activity and depression in college students: A systematic review and meta-analysis. Brain Sciences, 15(8), 875. https://doi.org/10.3390/brainsci15080875
Zhao, X.-D., Oh, S.-S., Zhang, Z., & Wang, C. (2025). Move your body, stay away from depression: A systematic review and meta-analysis of exercise-based prevention of depression in middle-aged and older adults. Frontiers in Public Health https://doi.org/10.3389/fpubh.2025.1554195
Noetel, M., Sanders, T., Gallardo-Gómez, D., Taylor, P., del Pozo Cruz, B., van den Hoek, D., Smith, J. J., Mahoney, J., & Spathis, J. (2024). Effect of exercise for depression: Systematic review and network meta-analysis of randomised controlled trials. BMJ, 384, e075847. https://doi.org/10.1136/bmj-2023-075847
Vos, T., Lim, S. S., Abbafati, C., et al. (2020). Global burden of 369 diseases and injuries in 204 countries and territories. Lancet, 396(10258), 1204–1222. https://doi.org/10.1016/S0140-6736(20)30925-9
Psaltopoulou, T., Sergentanis, T. N., Panagiotakos, D. B., et al. (2013). Mediterranean diet, stroke, cognitive impairment, and depression: A meta-analysis. Eur J Public Health, 23(5), 760–766. https://doi.org/10.1093/eurpub/ckt014
Dinan, T. G., & Cryan, J. F. (2017). The microbiome–gut–brain axis in health and disease. Biol Psychiatry, 82(5), 293–299. https://doi.org/10.1016/j.biopsych.2016.09.021
Pariante, C. M., & Lightman, S. L. (2008). The HPA axis in major depression. Lancet, 371(9617), 1194–1206. https://doi.org/10.1016/S0140-6736(08)60834-1
Lattie, E. G., Adkins, E. C., Winquist, N., et al. (2019). Digital mental health interventions. JMIR Ment Health, 6(6), e11192. https://doi.org/10.2196/11192
Lane, M. M., Gamage, E., Travica, N., et al. (2022). Ultra-processed food consumption and mental health: A systematic review and meta-analysis of observational studies. Nutrients, 14(13), 2568. https://doi.org/10.3390/nu14132568
Torous, J., Bucci, S., Bell, I. H., et al. (2021). The growing field of digital psychiatry: Current evidence and future directions. World Psychiatry, 20(3), 318–335. https://doi.org/10.1002/wps.20883
Huckvale, K., Nicholas, J., Torous, J., & Larsen, M. E. (2020). Smartphone apps for the treatment of mental health conditions: Status and considerations. Curr Opin Psychol, 36, 65–70. https://doi.org/10.1016/j.copsyc.2020.04.008
Riemann, D., Krone, L. B., Wulff, K., & Nissen, C. (2020). Sleep, insomnia, and depression. Neuropsychopharmacology, 45(1), 74–89. https://doi.org/10.1038/s41386-019-0411-y
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Copyright (c) 2026 Zuzanna Pyrka, Karina Brzózka, Alicja Piełuć, Adrianna Krupska, Weronika Cionżyńska, Katarzyna Ledwożyw, Zofia Ligas, Daniel Pyrka
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