ARTIFICIAL INTELLIGENCE IN PSYCHIATRIC DIAGNOSIS: CURRENT APPLICATIONS, CLINICAL POTENTIAL, AND EMERGING CHALLENGES - A COMPREHENSIVE REVIEW

Authors

DOI:

https://doi.org/10.31435/ijitss.3(51).2026.6118

Keywords:

Artificial Intelligence, Psychiatry, Machine Learning, Precision Psychiatry, Mental Health, Clinical Decision Support

Abstract

Artificial intelligence is being considered as a means of assisting psychiatric diagnosis, risk prediction, and long-term monitoring. Such applications in psychiatry have clinical relevance due to the fact that most psychiatric diagnosis is still based on interview, observation, and self-report, and also because it relies on symptom-based categorization that suffers from overlapping symptoms, tardiness in detection of illness, and discrepancies among patients given a single diagnosis. In this narrative review, we discuss applications of artificial intelligence in psychiatric assessment including machine learning, deep learning, natural language processing, digital phenotyping, large language models, and multimodal modelling. Papers published predominantly from 2020-2025 were included, with preference given to systematic reviews and meta-analyses, multicenter trials, and clinically significant publications.

It is evident that various computational models can detect valuable signatures in data obtained from electronic health records, neuroimaging, speech, clinical text, smartphone usage, wearable sensors, and social media. Such techniques can aid in the identification of depression, schizophrenia, bipolar disorder, anxiety disorders, and suicide risk. Multimodal approaches are particularly interesting due to the fact that they take the biological, psychological and social aspects of mental illness into consideration. On the other hand, the domain is currently suffering from insufficient and non-representative data sets, over-fitting, poor external validation, low interpretability, privacy issues, algorithmic bias, and unclear regulations. These aspects suggest that AI should be viewed as a supportive tool and not a replacement for the clinician.

References

American Psychiatric Association. (2022). Diagnostic and statistical manual of mental disorders (5th ed., text rev.). American Psychiatric Association Publishing.

Auf, H., Svedberg, P., Nygren, J., Nair, M., & Lundgren, L. (2025). The use of artificial intelligence in mental health services to support decision-making: Scoping review. Journal of Medical Internet Research, 27, e63548. https://doi.org/10.2196/63548

Bernert, R. A., Hilberg, A. M., Melia, R., Kim, J. P., Shah, N. H., & Abnousi, F. (2020). Artificial intelligence and suicide prevention: A systematic review of machine learning investigations. International Journal of Environmental Research and Public Health, 17(16), 5929. https://doi.org/10.3390/ijerph17165929

Bzdok, D., & Meyer-Lindenberg, A. (2021). Machine learning for precision psychiatry: Opportunities and challenges. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 6(3), 223–230. https://doi.org/10.1016/j.bpsc.2020.09.003

Bufano, P., Iacob, G., Banfi, G., & Gualtieri, P. (2023). Digital phenotyping for monitoring mental disorders: Systematic review. Journal of Medical Internet Research, 25, e46778. https://doi.org/10.2196/46778

Chia, A. Z. R., & Zhang, M. W. B. (2022). Digital phenotyping in psychiatry: A scoping review. Technology and Health Care, 30(6), 1331–1342. https://doi.org/10.3233/THC-213648

Collins, G. S., Reitsma, J. B., Altman, D. G., & Moons, K. G. M. (2015). Transparent reporting of a multivariable prediction model for individual prognosis or diagnosis (TRIPOD). Annals of Internal Medicine, 162(1), 55–63. https://doi.org/10.7326/M14-0697

D'Hotman, D., & Loh, E. (2020). AI enabled suicide prediction tools: A qualitative narrative review. BMJ Health & Care Informatics, 27(3), e100175. https://doi.org/10.1136/bmjhci-2020-100175

Dwyer, D. B., Falkai, P., & Koutsouleris, N. (2021). Machine learning approaches for clinical psychology and psychiatry. Annual Review of Clinical Psychology, 17, 91–118. https://doi.org/10.1146/annurev-clinpsy-081219-092940

Graham, S., Depp, C., Lee, E. E., Nebeker, C., Tu, X., Kim, H. C., & Jeste, D. V. (2020). Artificial intelligence for mental health and mental illnesses: An overview. Current Psychiatry Reports, 22, 116. https://doi.org/10.1007/s11920-020-01192-8

Guo, Z., Lai, A., Thygesen, J. H., Farrington, J., Keen, T., & Li, K. (2024). Large language models for mental health applications: Systematic review. JMIR Mental Health, 11, e57400. https://doi.org/10.2196/57400

Jung, H. W., Kim, D. Y., Lee, I., Kim, O., Lee, S., Lee, S., Chung, U. S., Kim, J.-H., Kim, S., Kim, J. W., Shin, A. L., & Lee, J. J. (2025). Key features of digital phenotyping for monitoring mental disorders: Systematic review. Journal of Medical Internet Research, 27, e77331. https://doi.org/10.2196/77331

Koutsouleris, N., Dwyer, D. B., Degenhardt, F., Maj, C., Urquijo-Castro, M. F., Sanfelici, R., Popovic, D., Oeztuerk, O., Haas, S. S., Weiske, J., Ruef, A., Kambeitz-Ilankovic, L., Antonucci, L. A., Neufang, S., Schmidt-Kraepelin, C., Ruhrmann, S., Penzel, N., Kambeitz, J., Haidl, T. K., ... Meisenzahl, E. (2021). Multimodal machine learning workflows for prediction of psychosis in patients with clinical high-risk syndromes and recent-onset depression. JAMA Psychiatry, 78(2), 195–209. https://doi.org/10.1001/jamapsychiatry.2020.3604

Le Glaz, A., Haralambous, Y., Kim-Dufor, D. H., Lenca, P., Billot, R., Ryan, T. C., Marsh, J., DeVylder, J., Walter, M., Berrouiguet, S., & Lemey, C. (2021). Machine learning and natural language processing in mental health: Systematic review. Journal of Medical Internet Research, 23(5), e15708. https://doi.org/10.2196/15708

Lee, E. E., Torous, J., De Choudhury, M., Depp, C. A., Graham, S. A., Kim, H.-C., Paulus, M. P., Krystal, J. H., & Jeste, D. V. (2021). Artificial intelligence for mental healthcare: Clinical applications, barriers, facilitators, and artificial wisdom. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 6(9), 856–864. https://doi.org/10.1016/j.bpsc.2021.02.001

Lin, E., Tsai, S. J., & Kuo, P. H. (2023). Precision psychiatry applications of artificial intelligence and machine learning. Journal of Affective Disorders, 324, 300–312. https://doi.org/10.1016/j.jad.2022.12.041

Liu, X., Rivera, S. C., Moher, D., Calvert, M. J., & Denniston, A. K. (2020). Reporting guidelines for clinical trial reports for interventions involving artificial intelligence: The CONSORT-AI extension. Nature Medicine, 26, 1364–1374. https://doi.org/10.1038/s41591-020-1034-x

Lundberg, S. M., & Lee, S.-I. (2017). A unified approach to interpreting model predictions. Advances in Neural Information Processing Systems, 30. https://proceedings.neurips.cc/paper/2017/hash/8a20a8621978632d76c43dfd28b67767-Abstract.html

Malgaroli, M., Hull, T. D., Zech, J. M., & Althoff, T. (2023). Natural language processing for mental health interventions: A systematic review and research framework. Translational Psychiatry, 13, 309. https://doi.org/10.1038/s41398-023-02592-2

Obermeyer, Z., Powers, B., Vogeli, C., & Mullainathan, S. (2019). Dissecting racial bias in an algorithm used to manage the health of populations. Science, 366(6464), 447–453. https://doi.org/10.1126/science.aax2342

Omar, M., Soffer, S., Charney, A. W., Landi, I., Nadkarni, G. N., & Klang, E. (2024). Applications of large language models in psychiatry: A systematic review. Frontiers in Psychiatry, 15, 1422807. https://doi.org/10.3389/fpsyt.2024.1422807

Pan, Y., Wang, P., Xue, B., Liu, Y., Shen, X., Wang, S., & Wang, X. (2025). Machine learning for the diagnosis accuracy of bipolar disorder: A systematic review and meta-analysis. Frontiers in Psychiatry, 15, 1515549. https://doi.org/10.3389/fpsyt.2024.1515549

Pigoni, A., Delvecchio, G., Turtulici, N., Madonna, D., Pietrini, P., Cecchetti, L., & Brambilla, P. (2024). Machine learning and the prediction of suicide in psychiatric populations: A systematic review. Translational Psychiatry, 14, 140. https://doi.org/10.1038/s41398-024-02852-9

Rajpurkar, P., Chen, E., Banerjee, O., & Topol, E. J. (2022). AI in health and medicine. Nature Medicine, 28(1), 31–38. https://doi.org/10.1038/s41591-021-01614-0

Ribeiro, M. T., Singh, S., & Guestrin, C. (2016). “Why should I trust you?”: Explaining the predictions of any classifier. Proceedings of the 22nd ACM SIGKDD International Conference on Knowledge Discovery and Data Mining, 1135–1144. https://doi.org/10.1145/2939672.2939778

Rony, M. K. K., Das, D. C., Khatun, M. T., Ferdousi, S., Akter, M. R., Khatun, M. A., Begum, M. H., Khalil, M. I., Parvin, M. R., Alrazeeni, D. M., & Akter, F. (2025). Artificial intelligence in psychiatry: A systematic review and meta-analysis of diagnostic and therapeutic efficacy. Digital Health, 11, 20552076251330528. https://doi.org/10.1177/20552076251330528

Sadeghi, Z., Alizadehsani, R., Cifci, M. A., Kausar, S., Rehman, R., Mahanta, P., Bora, P. K., Almasri, A., Alkhawaldeh, R. S., Hussain, S., Alatas, B., Shoeibi, A., Moosaei, H., Hladík, M., Nahavandi, S., & Pardalos, P. M. (2024). A review of explainable artificial intelligence in healthcare. Computers and Electrical Engineering, 118, 109370. https://doi.org/10.1016/j.compeleceng.2024.109370

Scherbakov, D. A., Hubig, N. C., Lenert, L. A., Alekseyenko, A. V., & Obeid, J. S. (2025). Natural language processing and social determinants of health in mental health research: AI-assisted scoping review. JMIR Mental Health, 12, e67192. https://doi.org/10.2196/67192

Shatte, A. B. R., Hutchinson, D. M., & Teague, S. J. (2019). Machine learning in mental health: A scoping review of methods and applications. Psychological Medicine, 49(9), 1426–1448. https://doi.org/10.1017/S0033291719000151

Tavory, T. (2024). Regulating AI in mental health: Ethics of care perspective. JMIR Mental Health, 11, e58493. https://doi.org/10.2196/58493

Teferra, B. G., Rueda, A., Pang, H., Valenzano, R., Samavi, R., Krishnan, S., & Bhat, V. (2024). Screening for depression using natural language processing: Literature review. Interactive Journal of Medical Research, 13, e55067. https://doi.org/10.2196/55067

Torous, J., Roberts, L. W., & Hsin, H. (2021). Ethical use of digital data and artificial intelligence in mental health. Current Psychiatry Reports, 23, 71. https://doi.org/10.1007/s11920-021-01275-5

Vaidyam, A. N., Wisniewski, H., Halamka, J. D., Kashavan, M. S., & Torous, J. B. (2021). Chatbots and conversational agents in mental health: A review of the psychiatric landscape. Canadian Journal of Psychiatry, 66(1), 16–24. https://doi.org/10.1177/0706743720959636

World Health Organization. (2019). International classification of diseases 11th revision (ICD-11). https://icd.who.int/

World Health Organization. (2022). World mental health report: Transforming mental health for all. https://www.who.int/publications/i/item/9789240049338

Zhang, Y., Wang, J., Zong, H., Singla, R. K., Ullah, A., Liu, X., Wu, R., Ren, S., & Shen, B. (2025). The comprehensive clinical benefits of digital phenotyping: From broad adoption to full impact. npj Digital Medicine, 8, 196. https://doi.org/10.1038/s41746-025-01602-5

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Published

2026-08-22

How to Cite

Wojtan, R., Szeszko, A. M., Czernek, W. M., Cichorzewska, M., Płachta, M., & Lubowiecka, M. (2026). ARTIFICIAL INTELLIGENCE IN PSYCHIATRIC DIAGNOSIS: CURRENT APPLICATIONS, CLINICAL POTENTIAL, AND EMERGING CHALLENGES - A COMPREHENSIVE REVIEW. International Journal of Innovative Technologies in Social Science, 2(3(51). https://doi.org/10.31435/ijitss.3(51).2026.6118

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