THE EFFECTS OF ASHWAGANDHA (WITHANIA SOMNIFERA) ON INSOMNIA AND SLEEP QUALITY - A NARRATIVE REVIEW

Authors

DOI:

https://doi.org/10.31435/ijitss.3(51).2026.6350

Keywords:

Ashwagandha, Insomia, Sleep Quality, Sleep Disturbances

Abstract

Insomnia is one of the most common sleep disorders in modern society and represents a major public health concern due to its wide-ranging impact on physical health, mental well-being, and overall quality of life. Due to the escalating prevalence of sleep disorders and the potential side effects associated with conventional pharmacotherapy, there is a growing clinical and public interest in natural substances that can safely support the treatment of insomnia.

The purpose of this review was to evaluate the current state of knowledge regarding the clinical and preclinical efficacy of Ashwagandha (Withania somnifera) in treating insomnia and sleep disturbances, while elucidating its underlying neurobiological mechanisms of action. A structured narrative literature review was conducted by searching major biomedical databases.

The analyzed studies demonstrated that ashwagandha supplementation leads to statistically significant improvements in sleep metrics. In patients diagnosed with insomnia, researchers reported a shortened sleep onset latency (SOL), reduced waking after sleep onset (WASO), and increased total sleep time (TST). The majority of findings consistently underscore that Ashwagandha’s most profound impact on sleep architecture is driven by its interactions with the GABAergic pathway. Furthermore, supplementation correlated with a significant reduction in serum cortisol levels by a multi-pathway mechanism of action involving the hypothalamic-pituitary-adrenal (HPA) axis. The extracts were well-tolerated, with only mild and transient adverse effects reported.

Ashwagandha represents an effective and safe therapeutic alternative for managing insomnia and enhancing sleep quality, particularly in individuals experiencing chronic stress.

References

Roth, T. (2007). Insomnia: Definition, prevalence, etiology, and consequences. Journal of Clinical Sleep Medicine, 3(5 Suppl), S7–S10.

Sateia, M. J., Buysse, D. J., Krystal, A. D., Neubauer, D. N., & Heald, J. L. (2017). Clinical practice guideline for the pharmacologic treatment of chronic insomnia in adults. Journal of Clinical Sleep Medicine, 13(2), 307–349. https://doi.org/10.5664/jcsm.6470

Shechter, A., Quispe, K. A., Mizhquiri Barbecho, J. S., Slater, C., & Falzon, L. (2020). Interventions to reduce short-wavelength (“blue”) light exposure at night and their effects on sleep: A systematic review and meta-analysis. Sleep Advances, 1(1), zpaa002. https://doi.org/10.1093/sleepadvances/zpaa002

Benz, F., Meneo, D., Baglioni, C., & Hertenstein, E. (2023). Insomnia symptoms as risk factor for somatic disorders: An umbrella review of systematic reviews and meta-analyses. Journal of Sleep Research, 32(6), e13984. https://doi.org/10.1111/jsr.13984

Katz, D. A., & McHorney, C. A. (1998). Clinical correlates of insomnia in patients with chronic illness. Archives of Internal Medicine, 158(10), 1099–1107. https://doi.org/10.1001/archinte.158.10.1099

Aquino, G., Benz, F., Dressle, R. J., Gemignani, A., Alfì, G., Palagini, L., Spiegelhalder, K., Riemann, D., & Feige, B. (2024). Towards the neurobiology of insomnia: A systematic review of neuroimaging studies. Sleep Medicine Reviews, 73, 101878.

Stepanski, E., Zorick, F., Roehrs, T., Young, D., & Roth, T. (1988). Daytime alertness in patients with chronic insomnia compared with asymptomatic control subjects. Sleep, 11(1), 54–60. https://doi.org/10.1093/sleep/11.1.54

Alvaro, P. K., Roberts, R. M., & Harris, J. K. (2013). A systematic review assessing bidirectionality between sleep disturbances, anxiety, and depression. Sleep, 36(7), 1059–1068. https://doi.org/10.5665/sleep.2810

Schwartz, M. D., & Kilduff, T. S. (2015). The neurobiology of sleep and wakefulness. Psychiatric Clinics of North America, 38(4), 615–644. https://doi.org/10.1016/j.psc.2015.07.002

Ashwagandha. (2024). In LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases. https://www.ncbi.nlm.nih.gov/books/

John, J. (2014). Therapeutic potential of Withania somnifera: A report on phyto-pharmacological properties. International Journal of Pharmaceutical Sciences and Research, 5, 2131–2148.

Wiciński, M., Fajkiel-Madajczyk, A., Kurant, Z., Kurant, D., Gryczka, K., Falkowski, M., Wiśniewska, M., Słupski, M., Ohla, J., & Zabrzyński, J. (2023). Can Ashwagandha benefit the endocrine system? A review. International Journal of Molecular Sciences, 24(22), 16513. https://doi.org/10.3390/ijms242216513

Candelario, M., Cuellar, E., Reyes-Ruiz, J. M., Darabedian, N., Feimeng, Z., Miledi, R., Russo-Neustadt, A., & Limon, A. (2015). Direct evidence for GABAergic activity of Withania somnifera. Journal of Ethnopharmacology, 171, 264–272. https://doi.org/10.1016/j.jep.2015.05.058

Mikulska, P., Malinowska, M., Ignacyk, M., et al. (2023). Ashwagandha (Withania somnifera)—Current research on health-promoting activities. Pharmaceutics, 15(4), 1057. https://doi.org/10.3390/pharmaceutics15041057

Langade, D., Thakare, V., Kanchi, S., & Kelgane, S. (2021). Clinical evaluation of Ashwagandha extract on sleep. Journal of Ethnopharmacology, 264, 113276. https://doi.org/10.1016/j.jep.2020.113276

Deshpande, A., Irani, N., Balkrishnan, R., & Benny, I. R. (2020). Ashwagandha extract improves sleep quality. Sleep Medicine, 72, 28–36. https://doi.org/10.1016/j.sleep.2020.03.012

Langade, D., Kanchi, S., Salve, J., Debnath, K., & Ambegaokar, D. (2019). Efficacy of Ashwagandha in insomnia and anxiety. Cureus, 11(9), e5797. https://doi.org/10.7759/cureus.5797

Kaushik, M. K., Kaul, S. C., Wadhwa, R., Yanagisawa, M., & Urade, Y. (2017). Triethylene glycol induces sleep. PLoS ONE, 12(2), e0172508. https://doi.org/10.1371/journal.pone.0172508

Murthy, S. V., Fathima, S. N., & Mote, R. (2022). Ashwagandha improves sleep via GABA and histamine modulation. Preventive Nutrition and Food Science, 27(1), 108–120. https://doi.org/10.3746/pnf.2022.27.1.108

Bhattarai, J. P., Park, S. A., & Han, S. K. (2010). Withania somnifera acts on GABA receptors. Phytotherapy Research, 24(8), 1147–1150. https://doi.org/10.1002/ptr.3088

Cheah, K. L., Norhayati, M. N., & Rahman, R. A. (2021). Effect of Ashwagandha on sleep: Systematic review and meta-analysis. PLoS ONE, 16(9), e0257843. https://doi.org/10.1371/journal.pone.0257843

Park, C. W., Hong, K. B., Suh, H. J., & Ahn, Y. (2023). Sleep-promoting activity of Ashwagandha via GABA receptors. Journal of Food and Drug Analysis, 31(2), 278–288. https://doi.org/10.38212/2224-6614.3456

Er, B., et al. (2025). Ashwagandha mitigates sleep deprivation-induced impairment. Biomolecules, 15(5), 710. https://doi.org/10.3390/biom15050710

Mahadevan, M., et al. (2025). Zenroot™ improves sleep quality. Advances in Therapy, 42(10), 5238–5254. https://doi.org/10.1007/s12325-025-03327-z

Kelgane, S. B., Salve, J., Sampara, P., & Debnath, K. (2020). Ashwagandha in elderly patients. Cureus, 12(2), e7083. https://doi.org/10.7759/cureus.7083

Berry, R. B. (2023). EEG normal sleep. In StatPearls. https://www.ncbi.nlm.nih.gov/books/NBK537023/

Kim, K., Uchiyama, M., Okawa, M., Liu, X., & Ogihara, R. (2012). Nonrestorative sleep. Sleep Medicine, 13(7), 786–794. https://doi.org/10.1016/j.sleep.2012.04.002

Staner, L. (2003). Sleep and anxiety disorders. Dialogues in Clinical Neuroscience, 5(3), 249–258. https://doi.org/10.31887/DCNS.2003.5.3/lstaner

Chandrasekhar, K., Kapoor, J., & Anishetty, S. (2012). Ashwagandha reduces stress and anxiety. Indian Journal of Psychological Medicine, 34(3), 255–262. https://doi.org/10.4103/0253-7176.106022

Nguyen, V., George, T., & Brewster, G. S. (2019). Insomnia in older adults. Current Geriatrics Reports, 8(4), 271–290. https://doi.org/10.1007/s13670-019-00300-x

Lee, Y., Kim, S., Park, J., et al. (2026). Ashwagandha modulates GABA and adenosine A1 receptors. Food Bioscience, 62, 105748. https://doi.org/10.1016/j.fbio.2026.105748

Bjorness, T. E., & Greene, R. W. (2009). Adenosine and sleep. Current Neuropharmacology, 7(3), 238–245. https://doi.org/10.2174/157015909789152182

de Pontes, A. L. B., et al. (2010). Serotonin and circadian rhythms. Psychology & Neuroscience, 3(2), 217–228. https://doi.org/10.3922/j.psns.2010.2.011

Sutanto, C. N., Loh, W. W., & Kim, J. E. (2022). The impact of tryptophan supplementation on sleep quality: A systematic review, meta-analysis, and meta-regression. Nutrition Reviews, 80(2), 306–316. https://doi.org/10.1093/nutrit/nuab027

Pérez-Piñero, S., Muñoz-Carrillo, J. C., Echepare-Taberna, J., et al. (2024). Effectiveness of enriched milk with Ashwagandha extract and tryptophan for improving subjective sleep quality in adults with sleep problems: A randomized double-blind controlled trial. Clocks & sleep, 6(3), 417–432. https://doi.org/10.3390/clockssleep6030028

Movva, N., Salve, J., Wankhede, K., et al. (2026). Comparative Evaluation of Ashwagandha (Withania somnifera) Root Extract and Melatonin for Improving Sleep Quality in Adults: A Prospective, Randomized, Double-Blind, Placebo-Controlled Study. Clocks & sleep, 8(2), 15. https://doi.org/10.3390/clockssleep8020015

Savage, R. A., Zafar, N., Yohannan, S., & Miller, J. M. M. (2024). Melatonin. In StatPearls. StatPearls Publishing.

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Published

2026-09-25

How to Cite

Wielogórska, A. M., Kamecki, A., Rak, Z., Ignatowska, Z., Dzień, K., Sarek, F., Jóźwik, K., & Kucharczyk, S. (2026). THE EFFECTS OF ASHWAGANDHA (WITHANIA SOMNIFERA) ON INSOMNIA AND SLEEP QUALITY - A NARRATIVE REVIEW. International Journal of Innovative Technologies in Social Science, 4(3(51). https://doi.org/10.31435/ijitss.3(51).2026.6350

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