THE IMPACT OF PHYSICAL ACTIVITY ON SURVIVAL OUTCOMES, TREATMENT RESPONSE, AND QUALITY OF LIFE IN PATIENTS WITH BREAST, COLORECTAL, AND PROSTATE CANCER: A NARRATIVE REVIEW
DOI:
https://doi.org/10.31435/ijitss.3(51).2026.6538Keywords:
Physical Activity, Exercise Oncology, Breast Cancer, Colorectal Cancer, Prostate CancerAbstract
Physical activity is increasingly recognized as an important component of comprehensive cancer care. This narrative review summarizes current evidence on the effects of exercise on survival outcomes, treatment response, and quality of life in patients with breast, colorectal, and prostate cancer. Regular exercise improves physical function, reduces cancer-related fatigue, enhances treatment tolerance, and may improve survival, particularly in breast and colorectal cancer. These benefits are mediated through anti-inflammatory, metabolic, and immunological mechanisms. Individualized exercise programmes should be integrated into routine oncology care.
References
Siegel, R. L., Giaquinto, A. N., & Jemal, A. (2024). Cancer statistics, 2024. CA Cancer J Clin, 74(1), 12–49. https://doi.org/10.3322/caac.21820
Michou, V., Zervoudis, S., Eskitzis, P., Tsamos, G., Vasdeki, D., Vouxinou, A., et al. (2025). Exercise interventions in breast cancer: Molecular mechanisms, physical benefits, and practical recommendations. Medicina (Lithuania). https://doi.org/10.3390/medicina61071167
Al-Mhanna, S. B., Batrakoulis, A., Noor, N. M., Mohamed, M., Drenowatz, C., Irekeola, A. A., et al. (2024). Combined aerobic and resistance training improves body composition, alters cardiometabolic risk, and ameliorates cancer-related indicators in breast cancer patients and survivors with overweight/obesity: A systematic review and meta-analysis of randomized controlled trials. Journal of Sports Science and Medicine, 366–395. https://doi.org/10.52082/jssm.2024.366
Oliveira, E. C., Correia, I. R., Bernardino, A. V., Hetherington-Rauth, M., Boavida, S., Sardinha, L. B., et al. (2025). Effect of exercise on immune system markers in cancer patients and survivors: A systematic review. Journal of Sports Science and Medicine, 645–665. https://doi.org/10.52082/jssm.2025.645
Ungvari, Z., Fekete, M., Varga, P., Munkácsy, G., Fekete, J. T., Lehoczki, A., et al. (2025). Exercise and survival benefit in cancer patients: Evidence from a comprehensive meta-analysis. Geroscience, 47(3), 5235–5255. https://doi.org/10.1007/s11357-025-01647-0
Wang, J., He, Y., Wang, Z., Wang, Z., Miao, Y., & Choi, J. Y. (2025). Effects of different exercise prescription parameters on metabolic and inflammatory biomarkers in cancer patients: A systematic review, meta-analysis, and meta-regression. Frontiers in Immunology. https://doi.org/10.3389/fimmu.2025.1663560
Rusu, L., Mihai, T. A., Schenker, R. A., Marin, M. I., Schenker, M., Streba, C. T., et al. (2025). The effect of physical exercises on TNF-α, IL-6, and IL-8 cytokines expression and NK cells in cancer. Romanian Journal of Morphology and Embryology, 89–98. https://doi.org/10.47162/RJME.66.1.08
Han, S., Du, C., Zhao, C., Zhang, Q., Wu, M., Yang, C., et al. (2026). Exercise-secreted antitumor myokines: Mechanistic insights and translational potential. Frontiers in Sports and Active Living. https://doi.org/10.3389/fspor.2026.1830759
Zhang, H., Zhang, Y., Luo, F., Wen, Y., Ni, J., & Wang, J. (2025). Physical exercise as a potential adjuvant therapy: Effects on inflammation and nutrition in colorectal cancer patients—a systematic review and meta-analysis. Frontiers in Nutrition. https://doi.org/10.3389/fnut.2025.1612674
Li, A., Sun, R., Wu, Y., Zhang, Q., Mao, R., Sun, X., et al. (2026). The role of exercise-induced myokines in cancer-associated inflammation and immune regulation: Mechanisms and prospects. Frontiers in Sports and Active Living. https://doi.org/10.3389/fspor.2026.1768179
Sun, Z., Han, T., Feng, L., Mao, D., Zhao, C., Han, J., et al. (2025). Effects of exercise interventions on breast cancer patients during adjuvant therapy: A systematic review and meta-analysis. Cancer Res Treat. https://doi.org/10.4143/crt.2025.762
Ohta, R., Fujimori, T., Tanaka, K., Sano, C., & Hayashi, H. (2025). The impact of exercise on overall survival in patients with metastatic colorectal cancer: A systematic review and meta-analysis. Cureus. https://doi.org/10.7759/cureus.97682
Nader, S., Massoud, A., Al-Obeidat, F., Mohamed, W. F., Hafez, W., Rashid, A., et al. (2024). Impact of aerobic and resistance training on fatigue, quality of life, and physical activity in prostate cancer patients: A systematic review and meta-analysis. Int J Surg, 110(10), 6170–6181. https://doi.org/10.1097/JS9.0000000000000982
Cagliari, M., Bressi, B., Bassi, M. C., Fugazzaro, S., Prati, G., Iotti, C., et al. (2022). Feasibility and safety of physical exercise to preserve bone health in men with prostate cancer receiving androgen deprivation therapy: A systematic review. Physical Therapy. https://doi.org/10.1093/ptj/pzab288
García-Miralles, N., Martínez-García, I., Marcilla-Toribio, I., Herreros-Solano, A., Fernández-Bravo-Rodrigo, J., Patiño-Cardona, S., et al. (2026). Association between physical activity and mortality in men with or at risk of prostate cancer: A systematic review. Healthcare, 14(13), 1998. https://doi.org/10.3390/healthcare14131998
Bettariga, F., Taaffe, D. R., Borsati, A., Avancini, A., Pilotto, S., Lazzarini, S. G., et al. (2025). Effects of exercise on inflammation in female survivors of nonmetastatic breast cancer: A systematic review and meta-analysis. J Natl Cancer Inst, 117(10), 1984–1998. https://doi.org/10.1093/jnci/djaf062
Avancini, A., Borsati, A., Toniolo, L., Ciurnelli, C., Belluomini, L., Budolfsen, T., et al. (2025). Physical activity guidelines in oncology: A systematic review of the current recommendations. Critical Reviews in Oncology/Hematology. https://doi.org/10.1016/j.critrevonc.2025.104718
Campbell, K. L., Winters-Stone, K. M., Wiskemann, J., May, A. M., Schwartz, A. L., Courneya, K. S., et al. (2019). Exercise guidelines for cancer survivors: Consensus statement from International Multidisciplinary Roundtable. Med Sci Sports Exerc, 51(11), 2375–2390. https://doi.org/10.1249/MSS.0000000000002116
Patel, A. V., Friedenreich, C. M., Moore, S. C., Hayes, S. C., Silver, J. K., Campbell, K. L., et al. (2019). American College of Sports Medicine roundtable report on physical activity, sedentary behavior, and cancer prevention and control. Medicine and Science in Sports and Exercise, 2391–2402. https://doi.org/10.1249/MSS.0000000000002117
Fretwell, A., Dobson, C., Orange, S. T., & Corfe, B. M. (2024). Diet and physical activity advice for colorectal cancer survivors: Critical synthesis of public-facing guidance. Supportive Care in Cancer, 32(9). https://doi.org/10.1007/s00520-024-08797-5
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Copyright (c) 2026 Iga Klepacz, Mateusz Kałwik, Dominika Groth, Wiktoria Dubiel, Aleksandra Lorent, Tomasz Szwarc, Martyna Rykowska
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