THE IMPACT OF DEPRESSION ON SEMEN QUALITY

Authors

DOI:

https://doi.org/10.31435/ijitss.3(51).2026.6543

Keywords:

Depression, Depressive Disorder, Semen Quality, Semen Analysis, Sperm Count

Abstract

Objective: Depression is characterized by low or depressed mood, anhedonia, feelings of guilt or worthlessness, lack of energy, fatigue, appetite changes, psychomotor retardation, sleep disturbances, or suicidal thoughts. Despite numerous studies analyzing the epidemiology, symptomatology, and treatment of depression, the impact on men’s reproductive health, semen quality, and procreation requires further research. This review aims to summarize the current state of knowledge about the impact of depression on semen parameters and quality.

Methods: PubMed,  ScienceDirect, and Google Scholar were systematically searched for studies. The search included original articles published from January 2017 to December 2026. Only studies in English and with full-text access were considered. Inclusion criteria focused on original research assessing depressive disorder, semen quality, and semen analysis. Data were extracted and synthesized narratively.

Key Findings: Depression significantly affects semen parameters and quality, causing a reduction in sperm motility, sperm density, and sperm concentration.

Conclusion: Depression has an impact on semen quality and reproductive health. This review highlights the importance of recognizing and addressing sexual dysfunction alongside psychological symptoms, as well as the need for a multidisciplinary approach to the management of depression. In the end, Further research and deeper investigation are necessary to fully examine the complex impacts of depression on semen quality, even though these collective studies demonstrate a strong correlation between mental health and fertility.

References

Abdoli, N., Salari, N., Darvishi, N., Jafarpour, S., Solaymani, M., Mohammadi, M., & Shohaimi, S. (2022). The global prevalence of major depressive disorder (MDD) among the elderly: A systematic review and meta-analysis. Neuroscience and Biobehavioral Reviews, 132, 1067–1073. https://doi.org/10.1016/j.neubiorev.2021.10.041

Ahmad, G., Iqbal, N., Feda, A. A., Shams, D. M., Alsaggaf, Y. H., Tahir, M., & Junaid, I. (2024). Temporal decline of semen quality amongst saudi population in first two decades of 21st century. Pathology, 56, S116. https://doi.org/10.1016/j.pathol.2023.12.383

Baroudi, M., Stoor, J. P., Blåhed, H., Edin, K., & Hurtig, A.-K. (2021). Men and sexual and reproductive healthcare in the Nordic countries: A scoping review. BMJ Open, 11(9), e052600. https://doi.org/10.1136/bmjopen-2021-052600

Borges, E., Setti, A. S., Braga, D. P. de A. F., Figueira, R. de C. S., & Iaconelli, A. (2015). Decline in semen quality among infertile men in Brazil during the past 10 years. International Brazilian Journal of Urology : Official Journal of the Brazilian Society of Urology, 41(4), 757–763. https://doi.org/10.1590/S1677-5538.IBJU.2014.0186

Cannarella, R., Condorelli, R. A., Gusmano, C., Barone, N., Burrello, N., Aversa, A., Calogero, A. E., & La Vignera, S. (2021). Temporal trend of conventional sperm parameters in a Sicilian population in the decade 2011-2020. Journal of Clinical Medicine, 10(5), 993. https://doi.org/10.3390/jcm10050993

Chan, J. K. N., Correll, C. U., Wong, C. S. M., Chu, R. S. T., Fung, V. S. C., Wong, G. H. S., Lei, J. H. C., & Chang, W. C. (2023). Life expectancy and years of potential life lost in people with mental disorders: A systematic review and meta-analysis. eClinicalMedicine, 65. https://doi.org/10.1016/j.eclinm.2023.102294

Chan, J. K. N., Solmi, M., Lo, H. K. Y., Chan, M. W. Y., Choo, L. L. T., Lai, E. T. H., Wong, C. S. M., Correll, C. U., & Chang, W. C. (2025). All‐cause and cause‐specific mortality in people with depression: A large‐scale systematic review and meta‐analysis of relative risk and aggravating or attenuating factors, including antidepressant treatment. World Psychiatry, 24(3), 404–421. https://doi.org/10.1002/wps.21354

Datta, J., Palmer, M. J., Tanton, C., Gibson, L. J., Jones, K. G., Macdowall, W., Glasier, A., Sonnenberg, P., Field, N., Mercer, C. H., Johnson, A. M., & Wellings, K. (2016). Prevalence of infertility and help seeking among 15 000 women and men. Human Reproduction, 31(9), 2108–2118. https://doi.org/10.1093/humrep/dew123

Durairajanayagam, D. (2018). Lifestyle causes of male infertility. Arab Journal of Urology, 16(1), 10–20. https://doi.org/10.1016/j.aju.2017.12.004

El-Khateeb, E. A., Mohamed, N. M. S., Ghobrial, P. F., & El-Husseiny, R. M. (2023). Impact of depression and the potential effect of its treatment on semen parameters. Middle East Current Psychiatry, 30(1), 117. https://doi.org/10.1186/s43045-023-00388-0

Gonçalves, W. S., Gherman, B. R., Abdo, C. H. N., Coutinho, E. S. F., Nardi, A. E., & Appolinario, J. C. (2023). Prevalence of sexual dysfunction in depressive and persistent depressive disorders: A systematic review and meta-analysis. International Journal of Impotence Research, 35(4), 340–349. https://doi.org/10.1038/s41443-022-00539-7

Gosling, R., Parry, S., & Stamou, V. (2022). Community support groups for men living with depression: Barriers and facilitators in access and engagement with services. Home Health Care Services Quarterly, 41(1), 20–39. https://doi.org/10.1080/01621424.2021.1984361

Indirli, R., Lanzi, V., Arosio, M., Mantovani, G., & Ferrante, E. (2023). The association of hypogonadism with depression and its treatments. Frontiers in Endocrinology, 14, 1198437. https://doi.org/10.3389/fendo.2023.1198437

Irvine, S., Cawood, E., Richardson, D., MacDonald, E., & Aitken, J. (1996). Evidence of deteriorating semen quality in the United Kingdom: Birth cohort study in 577 men in Scotland over 11 years. BMJ, 312(7029), 467–471. https://doi.org/10.1136/bmj.312.7029.467

Kaltsas, A., Koumenis, A., Stavropoulos, M., Kratiras, Z., Deligiannis, D., Adamos, K., & Chrisofos, M. (2025). Male infertility and reduced life expectancy: Epidemiology, mechanisms, and clinical implications. Journal of Clinical Medicine, 14(11), 3930. https://doi.org/10.3390/jcm14113930

Kooli, R., Sallem, A., Chebil, D., Boussabbeh, M., Mohamed, B. B., Ajina, T., Boughzela, I., Mougou, S., & Mehdi, M. (2023). Factors associated with anxiety and depression in men undergoing fertility investigations: A cross-sectional study. BMC Psychology, 11(1), 299. https://doi.org/10.1186/s40359-023-01330-z

Krumm, S., Krieg, G., Lamp, N., Marek, F., Nickel, P., Panzirsch, M., Stiawa, M., Beschoner, P., Brieger, P., Frasch, K., Gertzen, M., Gündel, H., Hasan, A., Jäger, M., Kling-Lourenco, P., Koussemou, J. M., Steber, R., & Kilian, R. (2023). The transformation of masculinity orientations and work-related attitudes in men treated for depression (TRANSMODE): Study protocol for a mixed-methods observational study. BMC Psychiatry, 23, 492. https://doi.org/10.1186/s12888-023-04979-3

Lam, R. W., Kennedy, S. H., Adams, C., Bahji, A., Beaulieu, S., Bhat, V., Blier, P., Blumberger, D. M., Brietzke, E., Chakrabarty, T., Do, A., Frey, B. N., Giacobbe, P., Gratzer, D., Grigoriadis, S., Habert, J., Ishrat Husain, M., Ismail, Z., McGirr, A., … Milev, R. V. (2024). Canadian Network for Mood and Anxiety Treatments (CANMAT) 2023 Update on Clinical Guidelines for Management of Major Depressive Disorder in Adults: Réseau canadien pour les traitements de l’humeur et de l’anxiété (CANMAT) 2023 : Mise à jour des lignes directrices cliniques pour la prise en charge du trouble dépressif majeur chez les adultes. Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie, 69(9), 641–687. https://doi.org/10.1177/07067437241245384

Levine, H., Jørgensen, N., Martino-Andrade, A., Mendiola, J., Weksler-Derri, D., Jolles, M., Pinotti, R., & Swan, S. H. (2023). Temporal trends in sperm count: A systematic review and meta-regression analysis of samples collected globally in the 20th and 21st centuries. Human Reproduction Update, 29(2), 157–176. https://doi.org/10.1093/humupd/dmac035

Liu, J., Dai, Y., Li, Y., Yuan, E., Wang, Q., Wang, X., & Guan, Y. (2020). A longitudinal study of semen quality among Chinese sperm donor candidates during the past 11 years. Scientific Reports, 10(1), 10771. https://doi.org/10.1038/s41598-020-67707-x

Liu, J., Liu, Y., Ma, W., Tong, Y., & Zheng, J. (2024). Temporal and spatial trend analysis of all-cause depression burden based on Global Burden of Disease (GBD) 2019 study. Scientific Reports, 14, 12346. https://doi.org/10.1038/s41598-024-62381-9

Maxwell, M. A., & Cole, D. A. (2009). Weight change and appetite disturbance as symptoms of adolescent depression: Toward an integrative biopsychosocial model. Clinical Psychology Review, 29(3), 260–273. https://doi.org/10.1016/j.cpr.2009.01.007

McKenzie, S. K., Oliffe, J. L., Black, A., & Collings, S. (2022). Men’s experiences of mental illness stigma across the lifespan: A scoping review. American Journal of Men’s Health, 16(1), 15579883221074789. https://doi.org/10.1177/15579883221074789

Mohebbi, M., Davoodian, N., Ganjali, S., Beilin, L. J., Berk, M., Forbes, M., McNeil, J. J., Nelson, M. R., Ryan, J., Wolfe, R., Woods, R. L., & Lotfaliany, M. (2025). Moderate alcohol consumption and risk of depression: A longitudinal analysis in community-dwelling older adults. Nutrients, 17(16), 2688. https://doi.org/10.3390/nu17162688

Murphy, M. J., & Peterson, M. J. (2015). Sleep disturbances in depression. Sleep Medicine Clinics, 10(1), 17–23. https://doi.org/10.1016/j.jsmc.2014.11.009

Nakhaee Moghadam, M., Ghaemi, M., Eskandari Delfan, S., Afshari, M., Kaveh, M., Eshraghi, N., & Shahraki, Z. (2024). Mood disorders and sexual function in infertile men: Exploring the relationship with semen analysis results. Andrologia, 2024(1), 1514237. https://doi.org/10.1155/2024/1514237

Odetayo, A. F., Akhigbe, R. E., Bassey, G. E., Hamed, M. A., & Olayaki, L. A. (2024). Impact of stress on male fertility: Role of gonadotropin inhibitory hormone. Frontiers in Endocrinology, 14. https://doi.org/10.3389/fendo.2023.1329564

Punjani, N., Kang, C., Flannigan, R., Bach, P., Altemus, M., Kocsis, J. H., Wu, A., Pierce, H., & Schlegel, P. N. (2021). Impact of duloxetine on male fertility: A randomised controlled clinical trial. Andrologia, 53(10), e14207. https://doi.org/10.1111/and.14207

Rahban, R., Priskorn, L., Senn, A., Stettler, E., Galli, F., Vargas, J., Van den Bergh, M., Fusconi, A., Garlantezec, R., Jensen, T. K., Multigner, L., Skakkebaek, N. E., Germond, M., Jørgensen, N., Nef, S., & NICER Working Group. (2019). Semen quality of young men in Switzerland: A nationwide cross-sectional population-based study. Andrology, 7(6), 818–826. https://doi.org/10.1111/andr.12645

Rodprasert, W., Virtanen, H. E., Sadov, S., Perheentupa, A., Skakkebæk, N. E., Jørgensen, N., & Toppari, J. (2019). An update on semen quality among young Finnish men and comparison with Danish data. Andrology, 7(1), 15–23. https://doi.org/10.1111/andr.12550

Shorey, S., Ng, E. D., & Wong, C. H. J. (2022). Global prevalence of depression and elevated depressive symptoms among adolescents: A systematic review and meta-analysis. The British Journal of Clinical Psychology, 61(2), 287–305. https://doi.org/10.1111/bjc.12333

Substance Abuse and Mental Health Services Administration. (2016). DSM-5 Changes: Implications for Child Serious Emotional Disturbance. Substance Abuse and Mental Health Services Administration (US). http://www.ncbi.nlm.nih.gov/books/NBK519708/

Tang, L., Li, D., & Wu, M. (n.d.). New highlights in cancer and depression multimorbidity: A scoping systematic review. Frontiers in Oncology, 15, 1674653. https://doi.org/10.3389/fonc.2025.1674653

Urata, M., Sakurai, H., Ueno, F., Maruki, T., Tada, T., Uchida, T., Matsumoto, Y., Murao, M., Tomita, M., Baba, H., Kato, M., Tsuboi, T., & Watanabe, K. (2025). Efficacy of pharmacological interventions in milder depression: A systematic review and meta‐Analysis. Neuropsychopharmacology Reports, 45(1), e70008. https://doi.org/10.1002/npr2.70008

Vander Borght, M., & Wyns, C. (2018). Fertility and infertility: Definition and epidemiology. Clinical Biochemistry, 62, 2–10. https://doi.org/10.1016/j.clinbiochem.2018.03.012

Walker, Z., Ernandez, J., Lanes, A., Srouji, S. S., Ginsburg, E., & Kathrins, M. (2023). The effects of male anxiety and depression on IVF outcomes. Human Reproduction, 38(11), 2119–2127. https://doi.org/10.1093/humrep/dead179

Wang, Y., He, L., Yang, Y., Tu, L., Yang, J., Zhang, Z., Meng, T., Jiang, X., Zhu, W., Li, Y., Zhang, H., Zhao, K., Zhang, X., & Liu, C. (2021). Association of Anxiety With Sperm Quality: A Multicentre Cross-sectional Study in China During the COVID-19 Outbreak. Research Square. https://doi.org/10.21203/rs.3.rs-664584/v1

Wdowiak, A., Bień, A., Iwanowicz-Palus, G., Makara-Studzińska, M., & Bojar, I. (2017). Impact of emotional disorders on semen quality in men treated for infertility. Neuro Endocrinology Letters, 38(1), 50–58.

Wdowiak, N., Wójtowicz, K., Wdowiak-Filip, A., Pucek, W., Wróbel, A., Wróbel, J., & Wdowiak, A. (2024). Environmental factors as the main hormonal disruptors of male fertility. Journal of Clinical Medicine, 13(7), 1986. https://doi.org/10.3390/jcm13071986

World Health Organization: WHO laboratory manual... - Google Scholar. (n.d.). Retrieved 13 August 2026, from https://scholar.google.com/scholar_lookup?title=WHO%20laboratory%20manual%20for%20the%20examination%20and%20processing%20of%20human%20semen&publication_year=2021

Xu, J., He, K., Zhou, Y., Zhao, L., Lin, Y., Huang, Z., Xie, N., Yue, J., & Tang, Y. (2022). The effect of SSRIs on Semen quality: A systematic review and meta-analysis. Frontiers in Pharmacology, 13, 911489. https://doi.org/10.3389/fphar.2022.911489

Yang, J.-S., Zhang, L.-Y., Yang, C.-H., Li, X.-Y., & Li, Z.-Q. (2024). Global, regional, and national epidemiology of depression in working-age individuals, 1990-2019. Depression and Anxiety, 2024, 4747449. https://doi.org/10.1155/2024/4747449

Ye, Y.-X., Chen, H.-G., Sun, B., Chen, Y.-J., Duan, P., Meng, T.-Q., Xiong, C.-L., Wang, Y.-X., & Pan, A. (2022). Associations between depression, oxidative stress, and semen quality among 1,000 healthy men screened as potential sperm donors. Fertility and Sterility, 117(1), 86–94. https://doi.org/10.1016/j.fertnstert.2021.09.013

Yland, J. J., Eisenberg, M. L., Hatch, E. E., Rothman, K. J., McKinnon, C. J., Nillni, Y. I., Sommer, G. J., Wang, T. R., & Wise, L. A. (2021). A North American prospective study of depression, psychotropic medication use, and semen quality. Fertility and Sterility, 116(3), 833–842. https://doi.org/10.1016/j.fertnstert.2021.03.052

Zhang, Y., Chen, B., Wang, Y., Liu, C., Sun, J., Zhang, Z., Guan, L., Xiao, K., Zhu, Z., & Luo, J. (2024). Association between mental health and male fertility: Depression, rather than anxiety, is linked to decreased semen quality. Frontiers in Endocrinology, 15, 1478848. https://doi.org/10.3389/fendo.2024.1478848

Downloads

Published

2026-09-24

How to Cite

Kulawinek, H., Mliczek, A., Obersztyn, J., Szczecińska, A. ., Glanert, W. ., Kasparek , K. M., Kasparek, G. ., Bajer, J. M., Czech , M. ., & Mrozek, P. . (2026). THE IMPACT OF DEPRESSION ON SEMEN QUALITY. International Journal of Innovative Technologies in Social Science, 5(3(51). https://doi.org/10.31435/ijitss.3(51).2026.6543