DOPAMINERGIC REGULATION OF SLEEP ARCHITECTURE AND DREAM GENERATION: FROM NEUROPSYCHIATRIC PATHOLOGY TO THE THERAPEUTIC POTENTIAL OF EXERCISE – A NARRATIVE REVIEW
DOI:
https://doi.org/10.31435/ijitss.3(51).2026.6586Keywords:
Dopamine, Exercise Signaling, Sleep Regulation, Sleep DisorderAbstract
Classically viewed as the primary mediator of reward, motivation, and exercise-induced euphoria, dopamine actually exerts highly nuanced, region- and receptor-specific effects on sleep architecture and dream generation. This narrative review synthesizes current literature from major scientific databases up to 2026 to elucidate how localized dopaminergic signaling acts as a homeostatic gatekeeper of overnight neurological restoration, and how its disruption drives sleep pathology across a broad clinical spectrum. Pathological breakdowns in dopaminergic pathways manifest as profound sleep fragmentation in Parkinson’s disease, circadian and phenomenological disturbances in schizophrenia, receptor desensitization linked to anhedonia in Major Depressive Disorder, neuroendocrine-driven hypersomnia in hyperprolactinemia, and failed fear extinction fueling recurrent nightmares in Post-Traumatic Stress Disorder. Crucially, this study evaluates the translational potential of physical exercise—particularly high-intensity interval training (HIIT)—as a non-pharmacological intervention. While respecting evolutionary limits in healthy organisms via the natural ceiling hypothesis, exercise opens a therapeutic window in deficit states, upregulating D₂ receptor density, stabilizing sleep microstructure through expanded N2 stages and sleep spindle activity, and enhancing slow-wave sleep. This prolongation of deep sleep ultimately accelerates glymphatic clearance, facilitating the convective removal of neurotoxic aggregates such as α-synuclein. By bridging the gap between exercise physiology, translational neurology, and sleep medicine, this review establishes a cohesive mechanistic framework for utilizing structured physical activity to protect vulnerable neural networks and transform the clinical management of complex motor and neuropsychiatric disorders.
References
Mutti, C., Siclari, F., & Rosenzweig, I. (2024). Dreaming conundrum. J Sleep Res, 34(2), e14338. https://doi.org/10.1111/jsr.14338
Toth, B. A., Chang, K. S., Fechtali, S., & Burgess, C. R. (2023). Dopamine release in the nucleus accumbens promotes REM sleep and cataplexy. iScience, 26(9), 107613. https://doi.org/10.1016/j.isci.2023.107613
Hasegawa, E., Miyasaka, A., Sakurai, K., Cherasse, Y., Li, Y., & Sakurai, T. (2022). Rapid eye movement sleep is initiated by basolateral amygdala dopamine signaling in mice. Science, 375(6584), 994–1000. https://doi.org/10.1126/science.abl6618
Perogamvros, L., & Schwartz, S. (2012). The roles of the reward system in sleep and dreaming. Neuroscience & Biobehavioral Reviews, 36(8), 1934–1951. https://doi.org/10.1016/j.neubiorev.2012.05.010
Zhang, J., Li, J., Liu, C. X., Gui, H., Yuan, C. D., & Zhang, Y. (2022). The role of intracerebral dopamine D1 and D2 receptors in sleep-wake cycles and general anesthesia. Ibrain, 8(1), 48–54. https://doi.org/10.1002/ibra.12024
Suzuki, K., Fujita, H., & Kobayashi, S. (2025). Managing sleep issues in parkinson's disease: An up-to- date review. Expert Rev Neurother, 25(2), 211–226. https://doi.org/10.1080/14737175.2025.2450789
Scanga, A., Lafontaine, A. L., & Kaminska, M. (2023). An overview of the effects of levodopa and dopamin- ergic agonists on sleep disorders in parkinson's disease. J Clin Sleep Med, 19(6), 1133–1144. https://doi.org/10.5664/jcsm.10450
Diaconu Ș, Falup-Pecurariu, O., Ținț, D., & Falup-Pecurariu, C. (2021). REM sleep behaviour disorder in parkinson's disease (review). Exp Ther Med, 22(2), 812. https://doi.org/10.3892/etm.2021.10244
Jiménez-Jiménez, F. J., Alonso-Navarro, H., Garc&́ia-Mart&́in, E., & Agúndez, J. A. G. (2021). Neurochemical features of Rem sleep behaviour disorder. J Pers Med, 11(9). https://doi.org/10.3390/jpm11090880
Ashton, A., & Jagannath, A. (2020). Disrupted sleep and circadian rhythms in schizophrenia and their interaction with dopamine signaling. Front Neurosci, 14, 636. https://doi.org/10.3389/fnins.2020.00636
Johansson, A. S., Owe-Larsson, B., Hetta, J., & Lundkvist, G. B. (2016). Altered circadian clock gene expres- sion in patients with schizophrenia. Schizophr Res, 174(1–3), 17–23. https://doi.org/10.1016/j.schres.2016.04.029
Manoach, D. S., Pan, J. Q., Purcell, S. M., & Stickgold, R. (2015). Reduced sleep spindles in schizophrenia: A treatable endophenotype that links risk genes to impaired cognition?. Biol Psychiatry, 80(8), 599–608. https://doi.org/10.1016/j.biopsych.2015.10.003
D'Agostino, A., Limosani, I., & Scarone, S. (2012). The dreaming brain/mind: A role in understanding complex mental disorders?. Front Psychiatry, 3, 3. https://doi.org/10.3389/fpsyt.2012.00003
Khazaie, H., Tahmasian, M., Younesi, G., C Schwebel, D., Rezaei, M., Rezaie, L., Mohamadi, M., & Ghanbari, A. (2012). Evaluation of dream content among patients with schizophrenia, their siblings, pa- tients with psychiatric diagnoses other than schizophrenia, and healthy control. Iran J Psychiatry, 7(1), 26–30. https://doi.org/10.1016/j.sleep.2013.11.391
Pizzagalli, D. A. (2022). Toward a better understanding of the mechanisms and pathophysiology of anhe- donia: Are we ready for translation?. Am J Psychiatry, 179(7), 458–469. https://doi.org/10.1176/appi.ajp.20220423
Barbato, G. (2023). Is REM density a measure of arousal during sleep?. Brain Sci, 13(3). https://doi.org/10.3390/brainsci13030378
Frau, R., Traccis, F., & Bortolato, M. (2019). Neurobehavioural complications of sleep deprivation: Shedding light on the emerging role of neuroactive steroids. J Neuroendocrinol, 32(1), e12792. https://doi.org/10.1111/jne.12792
Ditmer, M., Wojtera, A., Gabryelska, A., Turkiewicz, S., Białasiewicz, P., Strzelecki, D., & Sochal, M. (2026). Ghrelin's role in sleep and sleep deprivation: A narrative review. Front Psychiatry, 17, 1744781. https://doi.org/10.3389/fpsyt.2026.1744781
Bernier, V., Mungo, A., Point, C., Wacquier, B., Loas, G., & Hein, M. (2025). Recent change in anhedonia, major depression and Low-Grade inflammation: Dangerous liaisons? A study based on a cohort referred for polysomnography. Medicina (Kaunas), 61(12). https://doi.org/10.3390/medicina61122125
Kadiri, S. K., Tiwari, P., Khobragade, D. S., B S, D. G., & Rout, S. K. (2025). Neuroendocrine effects of hyper- prolactinemia: Focus on dopamine and serotonin systems. Endocr Metab Immune Disord Drug Targets. https://doi.org/10.2174/0118715303352625250526073105
Kirsch, P., Kunadia, J., Shah, S., & Agrawal, N. (2022). Metabolic effects of prolactin and the role of dopamine agonists: A review. Front Endocrinol (Lausanne), 13, 1002320. https://doi.org/10.3389/fendo.2022.1002320
Tóth, A., & Dobolyi, Á. (2025). Prolactin in sleep and EEG regulation: New mechanisms and sleep-related brain targets complement classical data. Neurosci Biobehav Rev, 169, 106000. https://doi.org/10.1016/j.neubiorev.2024.106000
Mogavero, M. P., Cosentino, F. I. I., Lanuzza, B., Tripodi, M., Lanza, G., Aricò, D., DelRosso, L. M., Pizza, F., Plazzi, G., & Ferri, R. (2021). Increased serum prolactin and excessive daytime sleepiness: An attempt of Proof-of-Concept study. Brain Sci, 11(12). https://doi.org/10.3390/brainsci11121574
Blum, K., McLaughlin, T., Modestino, E. J., Baron, D., Bowirrat, A., Brewer, R., Steinberg, B., Roy, A. K., Febo, M., Badgaiyan, R. D., & Gold, M. S. (2021). Epigenetic repair of terrifying lucid dreams by enhanced brain reward functional connectivity and induction of dopaminergic homeostatic signaling. Curr Psychopharmacol, 10. https://doi.org/10.2174/2211556010666210215153513
Oldoni, A. A., Bacchi, A. D., Mendes, F. R., Tiba, P. A., & Mota-Rolim, S. (2024). Neuropsychopharmacological induction of (lucid) dreams: A narrative review. Brain Sci, 14(5). https://doi.org/10.3390/brainsci14050426
Tyler, J., Podaras, M., Richardson, B., Roeder, N., Hammond, N., Hamilton, J., Blum, K., Gold, M., Baron, D. A., & Thanos, P. K. (2023). High intensity interval training exercise increases dopamine D2 levels and modulates brain dopamine signaling. Front Public Health, 11, 1257629. https://doi.org/10.3389/fpubh.2023.1257629
Speranza, L., Miniaci, M. C., & Volpicelli, F. (2025). The role of dopamine in neurological, psychiatric, and metabolic disorders and cancer: A complex web of interactions. Biomedicines, 13(2). https://doi.org/10.3390/biomedicines13020492
Rocha da, A. L., Pinto, A. P., Sousa Neto de, I. V., Muñoz, V. R., Marafon, B. B., Silva da, L. E. C. M., Pauli, J. R., Cintra, D. E., Ropelle, E. R., Simabuco, F. M., Moura de, L. P., Freitas de, E. C., Rivas, D. A., & Silva da, A. S. R. (2025). Exhaustive exercise abolishes REV-ERB-&́alpha circadian rhythm and shifts the kynurenine pathway to a neurotoxic profile in mice. J Physiol, 603(14), 3923–3944. https://doi.org/10.1113/jp288290
Ji, Y., Wang, B., Sun, X., Wang, Z., & Chen, W. (2025). The impact of physical activity on sleep architecture and cognitive function among college students. Front Psychiatry, 16, 1656278. https://doi.org/10.3389/fpsyt.2025.1656278
Shafiq, M. A., Singh, J., Khan, Z. A., Neary, J. P., & Bardutz, H. A. (2024). Effect of exercise on sleep quality in parkinson's disease: A mini review. BMC Neurol, 24(1), 49. https://doi.org/10.1186/s12883-024-03548-9
Cristini, J., Potvin-Desrochers, A., Seo, F., Dagher, A., Postuma, R. B., Rosa-Neto, P., Carrier, J., Amara, A. W., Steib, S., Paquette, C., & Roig, M. (2024). The effect of different types of exercise on sleep quality and architecture in Parkinson disease: A Single-Blinded randomized clinical trial protocol. Phys Ther, 104(1). https://doi.org/10.1093/ptj/pzad073
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Copyright (c) 2026 Wiktoria Łuniewska, Marta Modrzyk, Jakub Szkuta, Dawid Bartosik, Bartłomiej Ćwikła, Anastazja Murawska, Katarzyna Paulina Błatoń, Marcel Jancewicz, Olga Sławatyniec, Wiktoria Sobieraj, Jakub Chołast, Jakub Kacer
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