ALGORITHMIC SECOND OPINIONS IN PRIMARY CARE DERMATOLOGY: TRUST DYNAMICS AND AUTOMATION BIAS ACROSS SKIN LESIONS AND ERUPTIONS
DOI:
https://doi.org/10.31435/ijitss.3(51).2026.6625Keywords:
Artificial Intelligence, Primary Care, Dermatology, Automation Bias, Infectious Diseases, Inflammatory Rashes, Human-Computer InteractionAbstract
Dermatological complaints constitute a significant portion of primary care consultations, encompassing a broad spectrum from infectious exanthems and inflammatory rashes to malignant neoplasms. The recent integration of Artificial Intelligence (AI) into primary care settings promises to bridge the diagnostic accuracy gap between General Practitioners (GPs) and board-certified dermatologists. However, the socio-technical dynamics of how GPs calibrate trust in AI diagnostic suggestions remain poorly understood. This study investigates human-computer interaction, focusing on diagnostic confidence and automation bias, when physicians are provided with an AI-generated "second opinion." Utilizing an explanatory mixed-methods design, 50 clinicians—comprising 25 GPs (Novices in specialized dermatology) and 25 Dermatologists (Experts)—evaluated a curated dataset of 40 diverse macroscopic and dermoscopic clinical cases, including viral rashes, fungal infections, inflammatory dermatoses, and skin tumors. To assess automation bias, the AI assistant was programmed to provide deliberately incorrect diagnostic prompts in 20% of the cases. Quantitative results demonstrate a profound experience-based divergence. GPs, operating under higher diagnostic uncertainty, exhibited severe automation bias, frequently overturning correct initial diagnoses to align with erroneous AI prompts. Conversely, dermatologists demonstrated resilient diagnostic confidence but exhibited instances of algorithmic aversion, often rejecting the AI entirely due to its "black box" nature. The findings emphasize that deploying AI in primary care requires shifting focus from algorithmic accuracy to human-centered interface design, specifically integrating Explainable AI (XAI) paradigms to ensure safe and synergistic clinical decision-making.
References
Dietvorst, B. J., Simmons, J. P., & Massey, C. (2015). Algorithm aversion: People erroneously avoid algorithms after seeing them err. Journal of Experimental Psychology: General, 144(1), 114–126. https://doi.org/10.1037/xge0000033
Esteva, A., Kuprel, B., Novoa, R. A., Ko, J., Swetter, S. M., Blau, H. M., & Thrun, S. (2017). Dermatologist-level classification of skin cancer with deep neural networks. Nature, 542(7639), 115–118. https://doi.org/10.1038/nature21056
Liu, Y., Jain, A., Eng, C., Way, D. H., Lee, K., Bui, P., ... & Webster, D. R. (2020). A deep learning system for differential diagnosis of skin diseases. Nature Medicine, 26(6), 900–908. https://doi.org/10.1038/s41591-020-0842-3
Lowell, B. A., Froelich, C. W., Federman, D. G., & Kirsner, R. S. (2001). Dermatology in primary care: Prevalence and patient disposition. Journal of the American Academy of Dermatology, 45(2), 250–255. https://doi.org/10.1067/mjd.2001.114598
Parasuraman, R., & Riley, V. (1997). Humans and automation: Use, misuse, disuse, abuse. Human Factors, 39(2), 230–253. https://doi.org/10.1518/001872097778543886
Rajpurkar, P., Chen, E., Banerjee, O., & Topol, E. J. (2022). AI in health and medicine. Nature Medicine, 28(1), 31–38. https://doi.org/10.1038/s41591-021-01614-0
Creswell, J. W., & Plano Clark, V. L. (2018). Designing and conducting mixed methods research (3rd ed.). SAGE Publications.
Jian, J. Y., Bisantz, A. M., & Drury, C. G. (2000). Foundations for an empirically determined scale of trust in automated systems. International Journal of Cognitive Ergonomics, 4(1), 53–71. https://doi.org/10.1207/S15327566IJCE0401_04
Lyell, D., & Coiera, E. (2017). Automation bias and verification complexity: A systematic review. Journal of the American Medical Informatics Association, 24(2), 423–431. https://doi.org/10.1093/jamia/ocw105
World Medical Association. (2013). World Medical Association Declaration of Helsinki: Ethical principles for medical research involving human subjects. JAMA, 310(20), 2191–2194. https://doi.org/10.1001/jama.2013.281053
Blease, C., Kaptchuk, T. J., Bernstein, M. H., Mandl, K. D., Halamka, J. D., & DesRoches, C. M. (2019). Artificial intelligence and the future of primary care: Exploratory qualitative study of UK general practitioners’ views. Journal of Medical Internet Research, 21(3), e12802. https://doi.org/10.2196/12802
Croskerry, P. (2009). A universal model of diagnostic reasoning. Academic Medicine, 84(8), 1022–1028. https://doi.org/10.1097/ACM.0b013e3181ace703
Goddard, K., Roudsari, A., & Wyatt, J. C. (2012). Automation bias: A systematic review of frequency, effect mediators, and mitigators. Journal of the American Medical Informatics Association, 19(1), 121–127. https://doi.org/10.1136/amiajnl-2011-000089
London, A. J. (2019). Artificial intelligence and black-box medical decisions: Accuracy versus explainability. Hastings Center Report, 49(1), 15–21. https://doi.org/10.1002/hast.973
Elish, M. C. (2019). Moral crumple zones: Cautionary tales in human-robot interaction. Engaging Science, Technology, and Society, 5, 40–60. https://doi.org/10.17351/ests2019.260
Froomkin, A. M., Kerr, I., & Pineau, J. (2019). When AIs outperform doctors: Confronting the challenges of a tort-induced over-reliance on machine learning. Arizona Law Review, 61, 33–99.
Maliha, G., Gerke, S., Cohen, I. G., & Parikh, R. B. (2021). Artificial intelligence and liability in medicine: Balancing safety and innovation. The Milbank Quarterly, 99(3), 629–647. https://doi.org/10.1111/1468-0009.12504
Price, W. N., Gerke, S., & Cohen, I. G. (2019). Potential liability for physicians using artificial intelligence. JAMA, 322(18), 1765–1766. https://doi.org/10.1001/jama.2019.15064
Adamson, A. S., & Smith, A. (2018). Machine learning and health care disparities in dermatology. JAMA Dermatology, 154(11), 1247–1248. https://doi.org/10.1001/jamadermatol.2018.2348
Daneshjou, R., Smith, M. P., Sun, M. D., Rotemberg, V., & Zou, J. (2021). Lack of transparency and potential bias in artificial intelligence data sets and algorithms: A scoping review. JAMA Dermatology, 157(11), 1362–1369. https://doi.org/10.1001/jamadermatol.2021.3129
Zou, J., & Schiebinger, L. (2018). AI can be sexist and racist—it's time to make it fair. Nature, 559(7714), 324–326. https://doi.org/10.1038/d41586-018-05707-8
Asan, O., Bayrak, A. E., & Choudhury, A. (2020). Artificial intelligence and human trust in healthcare: Focus on clinicians. Journal of Medical Internet Research, 22(6), e15154. https://doi.org/10.2196/15154
Esmaeilzadeh, P. (2020). Use of AI-based tools for healthcare purposes: A survey study from consumers' perspectives. BMC Medical Informatics and Decision Making, 20(1), 170. https://doi.org/10.1186/s12911-020-01191-1
Kerasidou, A. (2020). Artificial intelligence and the ongoing need for empathy, compassion and trust in healthcare. Bulletin of the World Health Organization, 98(4), 245–250. https://doi.org/10.2471/BLT.19.237198
Ferrero, N. A., Morrell, D. S., & Burkhart, C. N. (2020). Skin scan: A demonstration of the need for FDA oversight of direct-to-consumer diagnostic smartphone apps. Journal of the American Academy of Dermatology, 82(2), 445–447. https://doi.org/10.1016/j.jaad.2019.08.064
Gomolin, A., Netchiporouk, E., Gniadecki, R., & Litvinov, I. V. (2020). Artificial intelligence applications in dermatology: Where do we stand?. Frontiers in Medicine, 7, 100. https://doi.org/10.3389/fmed.2020.00100
Nelson, C. A., & Roberson, M. L. (2022). The impact of teledermatology and artificial intelligence on the dermatology workforce and access to care. Dermatologic Clinics, 40(1), 101–110.
Bainbridge, L. (1983). Ironies of automation. Automatica, 19(6), 775–779. https://doi.org/10.1016/0005-1098(83)90046-8
Char, D. S., Shah, N. H., & Magnus, D. (2018). Implementing machine learning in health care—Addressing ethical challenges. The New England Journal of Medicine, 378(11), 981–983. https://doi.org/10.1056/NEJMp1714229
Verghese, A., Shah, N. H., & Harrington, R. A. (2018). What this computer needs is a physician: Humanism and artificial intelligence. JAMA, 319(1), 19–20. https://doi.org/10.1001/jama.2017.19198
Logg, J. M., Minson, J. A., & Moore, D. A. (2019). Algorithm appreciation: People prefer algorithmic to human judgment. Organizational Behavior and Human Decision Processes, 151, 90–103. https://doi.org/10.1016/j.obhdp.2018.12.005
Sinz, C., Tschandl, P., Rosendahl, C., Akay, B. N., Argenziano, G., Cabo, H., ... & Zalaudek, I. (2017). Accuracy of dermatoscopy for the diagnosis of nonpigmented cancers of the skin. Journal of the American Academy of Dermatology, 77(6), 1100–1109. https://doi.org/10.1016/j.jaad.2017.07.022
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