INTELLIGENT DIAGNOSTICS IN ENDOCRINOLOGY: THE POTENTIAL OF ARTIFICIAL INTELLIGENCE IN THE DETECTION AND EVALUATION OF THYROID NODULES

Authors

DOI:

https://doi.org/10.31435/ijitss.1(49).2026.3998

Keywords:

Fine Needle Aspiration Biopsy, FNAB, TIRADS, AI, Artificial Intelligence, Thyroid Nodules

Abstract

Advancements in artificial intelligence (AI) havesignificantly influenced the development of diagnostic tools in medicine, including endocrinology.Thyroid nodules are a prevalent clinical occurrence, and their accurate evaluation about malignancy risk is essential for treatment decisions. Conventional diagnostic techniques, like ultrasonography and fine-needle aspiration biopsy (FNAB),although effective, are burdened with subjectivity and limited availability of specialists.This article discusses the contemporary applications of artificial intelligence, including machine learning and deep learning algorithms, in the detection, classification, and evaluation of thyroid nodules utilizing ultrasound pictures and clinical data. The text compares the performance of AI models with expert evaluations and examines the possible advantages of their application in clinical practice, including enhanced diagnostic accuracy, standardized assessments, and decreased time to diagnosis.Despite the promising research findings, additional efforts are required to validate models in extensive populations and to integrate AI systems with current clinical protocols. Artificial intelligence possesses the potential to support as a substantial aid in the diagnosis of thyroid disorders; nevertheless, its comprehensive implementation necessitates the evaluation of ethical, legal, and organizational factors.

Aim of the study: The aim of this article is to assess the role of artificial intelligence in the diagnosis of thyroid nodules, with particular emphasis on the use of machine learning (ML) and deep learning (DL) algorithms in the analysis of ultrasound images, cancer risk classification, and clinical decision support. The  article aims to compare the effectiveness of AI-based systems with radiological assessment performed by specialists and to discuss the potential benefits and limitations of implementing these technologies in endocrinology practice. 

Materials and methods: A review of the literature available in the PubMed and Google Scholar databases was performed, using the key words: “Artificial Intelligence”, “AI”, “Thyroid Nodules”, “Fine Needle Aspiration Biopsy”, “FNAB”, “TIRADS”.

References

Pitoia, F., & Trimboli, P. (2024). New insights in thyroid diagnosis and treatment. Reviews in Endocrine and Metabolic Disorders, 25, 1–3. https://doi.org/10.1007/s11154-023-09859-5

Antonia, T. D., Maria, L. I., & Ancuta-Augustina, G. G. (2023). Preoperative evaluation of thyroid nodules: Diagnosis and management strategies. Pathology - Research and Practice, 246, Article 154516. https://doi.org/10.1016/j.prp.2023.154516

AlSaedi, A. H., Almalki, D. S., & ElKady, R. M. (2024). Approach to thyroid nodules: Diagnosis and treatment. Cureus. https://doi.org/10.7759/cureus.52232

Lotter, W., Hassett, M. J., Schultz, N., Kehl, K. L., Van Allen, E. M., & Cerami, E. (2024). Artificial intelligence in oncology: Current landscape, challenges, and future directions. Cancer Discovery, 14, 711–726. https://doi.org/10.1158/2159-8290.CD-23-1199

Lebrun, L., & Salmon, I. (2024). Pathology and new insights in thyroid neoplasms in the 2022 WHO classification. Current Opinion in Oncology, 36, 13–21. https://doi.org/10.1097/CCO.0000000000001012

Ali, S. Z., Baloch, Z. W., Cochand-Priollet, B., Schmitt, F. C., Vielh, P., & VanderLaan, P. A. (2023). The 2023 Bethesda System for Reporting Thyroid Cytopathology. Thyroid. https://doi.org/10.1089/thy.2023.0141

Bagıs, M., Can, N., Sut, N., Tastekin, E., Erdogan, E. G., Bulbul, B. Y., et al. (2024). A comprehensive approach to the thyroid Bethesda category III (AUS) in the transition zone between 2nd edition and 3rd edition of the Bethesda System for Reporting Thyroid Cytopathology: Subcategorization, nuclear scoring, and more. Endocrine Pathology, 35, 51–76. https://doi.org/10.1007/s12022-024-09797-1

Zahid, A., Shafiq, W., Nasir, K. S., Loya, A., Abbas Raza, S., Sohail, S., et al. (2021). Malignancy rates in thyroid nodules classified as Bethesda categories III and IV: A subcontinent perspective. Journal of Clinical and Translational Endocrinology, 23, Article 100250. https://doi.org/10.1016/j.jcte.2021.100250

Lind, P., Jacobson, A., Nordenström, E., Johansson, L., Wallin, G., & Daskalakis, K. (2024). Diagnostic sensitivity of fine-needle aspiration cytology in thyroid cancer. Scientific Reports, 14, Article 24216. https://doi.org/10.1038/s41598-024-75677-7

Poller, D. N., Johnson, S. J., & Bongiovanni, M. (2020). Measures to reduce diagnostic error and improve clinical decision making in thyroid FNA aspiration cytology: A proposed framework. Cancer Cytopathology, 128, 917–927. https://doi.org/10.1002/cncy.22309

Machała, E., Sopiński, J., Iavorska, I., & Kołomecki, K. (2018). Correlation of fine needle aspiration cytology of thyroid gland with histopathological results. Polish Journal of Surgery, 90, 1–5. https://doi.org/10.5604/01.3001.0012.4712

Sripodok, S., & Benjakul, N. (2023). Interobserver variability in inconclusive diagnostic categories of thyroid fine needle aspiration cytology: An urban-based tertiary hospital experience. Annals of Diagnostic Pathology, 63, Article 152083. https://doi.org/10.1016/j.anndiagpath.2022.152083

Ha, E. J., Suh, C. H., & Baek, J. H. (2018). Complications following ultrasound-guided core needle biopsy of thyroid nodules: A systematic review and meta-analysis. European Radiology, 28, 3848–3860. https://doi.org/10.1007/s00330-018-5367-5

Uppal, N., Collins, R., & James, B. (2023). Thyroid nodules: Global, economic, and personal burdens. Frontiers in Endocrinology, 14. https://doi.org/10.3389/fendo.2023.1113977

Tamhane, S., & Gharib, H. (2016). Thyroid nodule update on diagnosis and management. Clinical Diabetes and Endocrinology, 2. https://doi.org/10.1186/s40842-016-0035-7

Li, R., Li, G., Wang, Y., Bao, T., Lei, Y., Tian, L., et al. (2021). Psychological distress and sleep disturbance throughout thyroid nodule screening, diagnosis, and treatment. Journal of Clinical Endocrinology & Metabolism, 106, E4221–E4230. https://doi.org/10.1210/clinem/dgab224

Tessler, F. N., Middleton, W. D., Grant, E. G., Hoang, J. K., Berland, L. L., Teefey, S. A., et al. (2017). ACR Thyroid Imaging, Reporting and Data System (TI-RADS): White paper of the ACR TI-RADS Committee. Journal of the American College of Radiology, 14, 587–595. https://doi.org/10.1016/j.jacr.2017.01.046

Ludwig, M., Ludwig, B., Mikuła, A., Biernat, S., Rudnicki, J., & Kaliszewski, K. (2023). The use of artificial intelligence in the diagnosis and classification of thyroid nodules: An update. Cancers, 15. https://doi.org/10.3390/cancers15030708

Shreyamsa, M., Mishra, A., Ramakant, P., Parihar, A., Singh, K., Rana, C., et al. (2020). Comparison of multimodal ultrasound imaging with conventional ultrasound risk stratification systems in presurgical risk stratification of thyroid nodules. Indian Journal of Endocrinology and Metabolism, 24, 537–542. https://doi.org/10.4103/ijem.IJEM_675_20

Zhao, C. K., Ren, T. T., Yin, Y. F., Shi, H., Wang, H. X., Zhou, B. Y., et al. (2021). A comparative analysis of two machine learning-based diagnostic patterns with thyroid imaging reporting and data system for thyroid nodules: Diagnostic performance and unnecessary biopsy rate. Thyroid, 31, 470–481. https://doi.org/10.1089/thy.2020.0305

Gruson, D., Dabla, P., Stankovic, S., Homsak, E., Gouget, B., Bernardini, S., et al. (2022). Artificial intelligence and thyroid disease management: Considerations for thyroid function tests. Biochemia Medica, 32. https://doi.org/10.11613/BM.2022.020601

Sureshkumar, V., Jaganathan, D., Ravi, V., Velleangiri, V., & Ravi, P. (2024). A comparative study on thyroid nodule classification using transfer learning methods. Open Bioinformatics Journal, 17. https://doi.org/10.2174/0118750362305982240627034926

Amer, H. M., Nasr, S. A., Abdel-Fattah, H. M., Abdelsalam, M. M., & El-Din Moustafa, H. (2023). An accurate deep learning based framework for detection of thyroid cancer using ultrasound images. Vol. 24.

Liang, J., Pang, T., Liu, W., Li, X., Huang, L., Gong, X., et al. (2023). Comparison of six machine learning methods for differentiating benign and malignant thyroid nodules using ultrasonographic characteristics. BMC Medical Imaging, 23. https://doi.org/10.1186/s12880-023-01117-z

Cao, C. L., Li, Q. L., Tong, J., Shi, L. N., Li, W. X., Xu, Y., et al. (2023). Artificial intelligence in thyroid ultrasound. Frontiers in Oncology, 13. https://doi.org/10.3389/fonc.2023.1060702

Weng, J., Wildman-Tobriner, B., Buda, M., Yang, J., Ho, L. M., Allen, B. C., et al. (n.d.). Deep learning for classification of thyroid nodules on ultrasound: Validation on an independent dataset.

Choi, Y. J., Baek, J. H., Park, H. S., Shim, W. H., Kim, T. Y., Shong, Y. K., et al. (2017). A computer-aided diagnosis system using artificial intelligence for the diagnosis and characterization of thyroid nodules on ultrasound: Initial clinical assessment. Thyroid, 27, 546–552. https://doi.org/10.1089/thy.2016.0372

Zhao, W. J., Fu, L. R., Huang, Z. M., Zhu, J. Q., Ma, B. Y., & Tarantino, G. (2019). Effectiveness evaluation of computer-aided diagnosis system for the diagnosis of thyroid nodules on ultrasound: A systematic review and meta-analysis. Medicine, 98. https://doi.org/10.1097/MD.0000000000016379

Xia, M., Song, F., Zhao, Y., Xie, Y., Wen, Y., & Zhou, P. (2023). Ultrasonography-based radiomics and computer-aided diagnosis in thyroid nodule management: Performance comparison and clinical strategy optimization. Frontiers in Endocrinology, 14. https://doi.org/10.3389/fendo.2023.1140816

Lee, Y., Alam, M. R., Park, H., Yim, K., Seo, K. J., Hwang, G., et al. (2024). Improved diagnostic accuracy of thyroid fine-needle aspiration cytology with artificial intelligence technology. Thyroid, 34, 723–734. https://doi.org/10.1089/thy.2023.0384

Cece, A., Agresti, M., De Falco, N., Sperlongano, P., Moccia, G., Luongo, P., et al. (2025). Role of artificial intelligence in thyroid cancer diagnosis. Journal of Clinical Medicine, 14. https://doi.org/10.3390/jcm14072422

Jia, X., Ma, Z., Kong, D., Li, Y., Hu, H., Guan, L., et al. (2022). Novel human artificial intelligence hybrid framework pinpoints thyroid nodule malignancy and identifies overlooked second-order ultrasonographic features. Cancers, 14. https://doi.org/10.3390/cancers14184440

Pathak, A., Yu, Z., Paredes, D., Monsour, P., Rocha, A. O., & Brito, J. P., et al. (n.d.). Extracting thyroid nodules characteristics from ultrasound reports using transformer-based natural language processing methods.

Yu, Y., Ouyang, W., Huang, Y., Huang, H., Wang, Z., Jia, X., et al. (2024). AI-based multimodal multi-tasks analysis reveals tumor molecular heterogeneity, predicts preoperative lymph node metastasis and prognosis in papillary thyroid carcinoma: A retrospective study. International Journal of Surgery. https://doi.org/10.1097/js9.0000000000001875

Slabaugh, G., Beltran, L., Rizvi, H., Deloukas, P., & Marouli, E. (2023). Applications of machine and deep learning to thyroid cytology and histopathology: A review. Frontiers in Oncology, 13. https://doi.org/10.3389/fonc.2023.958310

Liang, Q., Qi, Z., & Li, Y. (2024). Machine learning to predict the occurrence of thyroid nodules: Towards a quantitative approach for judicious utilization of thyroid ultrasonography. Frontiers in Endocrinology, 15. https://doi.org/10.3389/fendo.2024.1385836

Peng, S., Liu, Y., Lv, W., Liu, L., Zhou, Q., Yang, H., et al. (2021). Deep learning-based artificial intelligence model to assist thyroid nodule diagnosis and management: A multicentre diagnostic study. The Lancet Digital Health, 3, e250–e259. https://doi.org/10.1016/S2589-7500(21)00041-8

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Published

2026-03-16

How to Cite

INTELLIGENT DIAGNOSTICS IN ENDOCRINOLOGY: THE POTENTIAL OF ARTIFICIAL INTELLIGENCE IN THE DETECTION AND EVALUATION OF THYROID NODULES. (2026). International Journal of Innovative Technologies in Social Science, 2(1(49). https://doi.org/10.31435/ijitss.1(49).2026.3998

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