OVERWEIGHT AND OBESITY IN CHILDHOOD CANCER SURVIVORS: A LITERATURE REVIEW

Authors

DOI:

https://doi.org/10.31435/ijitss.2(50).2026.5104

Keywords:

BMI, Cancer, Cancer Survivors, Lifestyle, Nutrition, Obesity

Abstract

Introduction: Overweight and obesity have become a widespread problem in modern society, influenced by multiple factors, including oncological diseases and their treatment. A diagnosis of cancer at a young age, combined with adverse lifestyle patterns, may lead to significant challenges in maintaining healthy Body Mass Index (BMI). A BMI ≥30 kg/m2 is classified as obesity and may lead to multiple health complications, posing an additional burden for cancer survivors. The aim of this review is to present the current state of knowledge on the association between early-onset cancer and excessive weight gain.

Methods: This study presents current knowledge on overweight and obesity in childhood cancer survivors. A narrative literature review was conducted using PubMed and Google Scholar, focusing on recent studies and cardiometabolic risk factors.

Key findings: Survivors of childhood cancer are at risk of developing obesity compared to their peers. Studies show that they often face greater difficulties in maintaining normal body weight than their healthy siblings. Excessive body weight is associated with comorbidities such as hypertension, hyperglycemia, dyslipidemia, chronic inflammation, which require further treatment and can affect long-term health. Preventive strategies focusing on nutrition and physical activity are crucial for this group.

Conclusion: Despite the widespread prevalence of obesity, limited research focuses on its determinants in childhood cancer survivors. The maintenance of a healthy body weight is particularly important in this group to prevent secondary health complications. Therefore, supporting the development of healthy lifestyle patterns in this vulnerable population is vital for improving their long-term outcomes.

References

Smith, K. B., & Smith, M. S. (2016). Obesity statistics. Primary Care, 43(1), 121–ix. https://doi.org/10.1016/j.pop.2015.10.001

Greenlee, H., Unger, J. M., LeBlanc, M., Ramsey, S., & Hershman, D. L. (2017). Association between body mass index and cancer survival in a pooled analysis of 22 clinical trials. Cancer Epidemiology, Biomarkers & Prevention, 26(1), 21–29. https://doi.org/10.1158/1055-9965.EPI-15-1336

Reinehr, T., & Wabitsch, M. (2011). Childhood obesity. Current Opinion in Lipidology, 22(1), 21–25. https://doi.org/10.1097/MOL.0b013e32833f9c37

Zhang, F. F., & Parsons, S. K. (2015). Obesity in childhood cancer survivors: Call for early weight management. Advances in Nutrition, 6(5), 611–619. https://doi.org/10.3945/an.115.008946

Petrelli, F., Cortellini, A., Indini, A., Tomasello, G., Ghidini, M., Nigro, O., Salati, M., Dottorini, L., Iaculli, A., Varricchio, A., Rampulla, V., Barni, S., Cabiddu, M., Bossi, A., Ghidini, A., & Zaniboni, A. (2021). Association of obesity with survival outcomes in patients with cancer: A systematic review and meta-analysis. JAMA Network Open, 4(3), e213520. https://doi.org/10.1001/jamanetworkopen.2021.3520

Kivimäki, M., Strandberg, T., Pentti, J., Nyberg, S. T., Frank, P., Jokela, M., Ervasti, J., Suominen, S. B., Vahtera, J., Sipilä, P. N., Lindbohm, J. V., & Ferrie, J. E. (2022). Body-mass index and risk of obesity-related complex multimorbidity: An observational multicohort study. The Lancet Diabetes & Endocrinology, 10(4), 253–263. https://doi.org/10.1016/S2213-8587(22)00033-X

Jiang, S. Z., Lu, W., Zong, X. F., Ruan, H. Y., & Liu, Y. (2016). Obesity and hypertension. Experimental and Therapeutic Medicine, 12(4), 2395–2399. https://doi.org/10.3892/etm.2016.3667

Cazettes, F., Cohen, J. I., Yau, P. L., Talbot, H., & Convit, A. (2011). Obesity-mediated inflammation may damage the brain circuit that regulates food intake. Brain Research, 1373, 101–109. https://doi.org/10.1016/j.brainres.2010.12.008

Zbrzeźniak-Suszczewicz, J., Winiarska, A., Perkowska-Ptasińska, A., & Stompór, T. (2025). Obesity-related glomerulosclerosis: How adiposity damages the kidneys. International Journal of Molecular Sciences, 26(13), 6247. https://doi.org/10.3390/ijms26136247

Ledwozyw, A., Michalak, J., Stepień, A., & Kadziołka, A. (1986). The relationship between plasma triglycerides, cholesterol, total lipids and lipid peroxidation products during human atherosclerosis. Clinica Chimica Acta, 155(3), 275–283. https://doi.org/10.1016/0009-8981(86)90247-0

Jebari-Benslaiman, S., Galicia-García, U., Larrea-Sebal, A., Olaetxea, J. R., Alloza, I., Vandenbroeck, K., Benito-Vicente, A., & Martín, C. (2022). Pathophysiology of atherosclerosis. International Journal of Molecular Sciences, 23(6), 3346. https://doi.org/10.3390/ijms23063346

Koopman, R. J., Swofford, S. J., Beard, M. N., & Meadows, S. E. (2009). Obesity and metabolic disease. Primary Care, 36(2), 257–270. https://doi.org/10.1016/j.pop.2009.01.006

Vigneri, P., Frasca, F., Sciacca, L., Pandini, G., & Vigneri, R. (2009). Diabetes and cancer. Endocrine-Related Cancer, 16(4), 1103–1123. https://doi.org/10.1677/ERC-09-0087

Wadden, T. A., Tronieri, J. S., & Butryn, M. L. (2020). Lifestyle modification approaches for the treatment of obesity in adults. American Psychologist, 75(2), 235–251. https://doi.org/10.1037/amp0000517

Marra, M., Sammarco, R., De Lorenzo, A., Iellamo, F., Siervo, M., Pietrobelli, A., Donini, L. M., Santarpia, L., Cataldi, M., Pasanisi, F., & Contaldo, F. (2019). Assessment of body composition in health and disease using bioelectrical impedance analysis (BIA) and dual energy X-ray absorptiometry (DXA): A critical overview. Contrast Media & Molecular Imaging, 2019, 3548284. https://doi.org/10.1155/2019/3548284

Rothman, K. J. (2008). BMI-related errors in the measurement of obesity. International Journal of Obesity, 32(Suppl. 3), S56–S59. https://doi.org/10.1038/ijo.2008.87

Brown, C. L., Halvorson, E. E., Cohen, G. M., Lazorick, S., & Skelton, J. A. (2015). Addressing childhood obesity: Opportunities for prevention. Pediatric Clinics of North America, 62(5), 1241–1261. https://doi.org/10.1016/j.pcl.2015.05.013

Styne, D. M., Arslanian, S. A., Connor, E. L., Farooqi, I. S., Murad, M. H., Silverstein, J. H., & Yanovski, J. A. (2017). Pediatric obesity—Assessment, treatment, and prevention: An Endocrine Society clinical practice guideline. The Journal of Clinical Endocrinology & Metabolism, 102(3), 709–757. https://doi.org/10.1210/jc.2016-2573

Hudson, M. M., Ness, K. K., Gurney, J. G., Mulrooney, D. A., Chemaitilly, W., Krull, K. R., Green, D. M., Armstrong, G. T., Nottage, K. A., Jones, K. E., Sklar, C. A., Srivastava, D. K., & Robison, L. L. (2013). Clinical ascertainment of health outcomes among adults treated for childhood cancer. JAMA, 309(22), 2371–2381. https://doi.org/10.1001/jama.2013.6296

Garmey, E. G., Liu, Q., Sklar, C. A., Meacham, L. R., Mertens, A. C., Stovall, M. A., Yasui, Y., Robison, L. L., & Oeffinger, K. C. (2008). Longitudinal changes in obesity and body mass index among adult survivors of childhood acute lymphoblastic leukemia: A report from the Childhood Cancer Survivor Study. Journal of Clinical Oncology, 26(28), 4639–4645. https://doi.org/10.1200/JCO.2008.16.3527

Devilli, L., Garonzi, C., Balter, R., Bonetti, E., Chinello, M., Zaccaron, A., Vitale, V., De Bortoli, M., Caddeo, G., Baretta, V., Tridello, G., & Cesaro, S. (2021). Long-term and quality of survival in patients treated for acute lymphoblastic leukemia during the pediatric age. Hematology Reports, 13(1), 8847. https://doi.org/10.4081/hr.2021.8847

Zhang, X., Liu, J., Ni, Y., Yi, C., Fang, Y., Ning, Q., Shen, B., Zhang, K., Liu, Y., Yang, L., Li, K., Liu, Y., Huang, R., & Li, Z. (2024). Global prevalence of overweight and obesity in children and adolescents: A systematic review and meta-analysis. JAMA Pediatrics, 178(8), 800–813. https://doi.org/10.1001/jamapediatrics.2024.1576

Gance-Cleveland, B., Linton, A., Arbet, J., Stiller, D., & Sylvain, G. (2020). Predictors of overweight and obesity in childhood cancer survivors. Journal of Pediatric Oncology Nursing, 37(3), 154–162. https://doi.org/10.1177/1043454219897102

Jakicic, J. M., Rogers, R. J., Davis, K. K., & Collins, K. A. (2018). Role of physical activity and exercise in treating patients with overweight and obesity. Clinical Chemistry, 64(1), 99–107. https://doi.org/10.1373/clinchem.2017.272443

Bouwman, E., Penson, A., de Valk, M., van den Oever, S. R., van der Pal, H. J. H., van Dulmen-den Broeder, E., Blijlevens, N. M. A., Bresters, D., Feijen, E. A. M., van den Heuvel-Eibrink, M. M., van der Heiden-van der Loo, M., Michel, G., Ronckers, C. M., Teepen, J. C., Tissing, W. J. E., Versluys, B. A. B., Kremer, L. C. M., Pluijm, S. M. F., Loonen, J. J., Dutch LATER Study Group, & the PanCareFollowUp Consortium. (2024). Unhealthy lifestyle behaviors, overweight, and obesity among childhood cancer survivors in the Netherlands: A DCCSS LATER study. Cancer, 130(16), 2856–2872. https://doi.org/10.1002/cncr.35338

Romieu, I., Dossus, L., Barquera, S., Blottière, H. M., Franks, P. W., Gunter, M., Hwalla, N., Hursting, S. D., Leitzmann, M., Margetts, B., Nishida, C., Potischman, N., Seidell, J., Stepien, M., Wang, Y., Westerterp, K., Winichagoon, P., Wiseman, M., Willett, W. C., & IARC Working Group on Energy Balance and Obesity. (2017). Energy balance and obesity: What are the main drivers? Cancer Causes & Control, 28(3), 247–258. https://doi.org/10.1007/s10552-017-0869-z

Friedman, D. N., Tonorezos, E. S., & Cohen, P. (2019). Diabetes and metabolic syndrome in survivors of childhood cancer. Hormone Research in Paediatrics, 91(2), 118–127. https://doi.org/10.1159/000495698

Panuganti, K. K., Nguyen, M., Kshirsagar, R. K., & Doerr, C. (2023). Obesity (nursing). In StatPearls. StatPearls Publishing.

Bratteteig, M., Rueegg, C. S., Lie, H. C., Thorsen, L., Larsen, E. H., Larsen, M. H., Torsvik, I. K., Götte, M., Järvelä, L. S., Kriemler, S., Larsen, H. B., Anderssen, S. A., Ruud, E., & Grydeland, M. (2024). Physical activity behaviors and screen time in young childhood cancer survivors: The Physical Activity in Childhood Cancer Survivors Study. Journal of Cancer Survivorship. Advance online publication. https://doi.org/10.1007/s11764-024-01671-7

Feit, T., Beals, E., Dandekar, S., Kadan-Lottick, N., & Joffe, L. (2024). Nutritional assessment and dietary intervention among survivors of childhood cancer: Current landscape and a look to the future. Frontiers in Nutrition, 10, 1343104. https://doi.org/10.3389/fnut.2023.1343104

Konończuk, K., Muszyńska-Rosłan, K., Konstantynowicz-Nowicka, K., Chabowski, A., & Latoch, E. (2025). Altered free fatty acids levels and the onset of metabolic syndrome in childhood cancer survivors. Nutrition, 136, 112799. https://doi.org/10.1016/j.nut.2025.112799

Casirati, A., Somaschini, A., Muraca, M., Cereda, E., Morsellino, V., Di Iorgi, N., Caccialanza, R., & Haupt, R. (2023). Fat-to-lean mass ratio as a tool to detect the dysmetabolic profile in childhood cancer survivors. Nutrition, 113, 112129. https://doi.org/10.1016/j.nut.2023.112129

Delacourt, L., Allodji, R., Chappat, J., Haddy, N., El-Fayech, C., Demoor-Goldschmidt, C., Journy, N., Bolle, S., Thomas-Teinturier, C., Zidane, M., Rubino, C., Veres, C., Vu-Bezin, G., Berchery, D., Pluchart, C., Bondiau, P. Y., Dumas, A., Bougas, N., Grill, J., Dufour, C., ... de Vathaire, F. (2023). Risk factors for obesity in adulthood among survivors of childhood cancer. Obesity, 31(7), 1942–1952. https://doi.org/10.1002/oby.23784

Dixon, S. B., Wang, F., Lu, L., Wilson, C. L., Green, D. M., Merchant, T. E., Srivastava, D. K., Delaney, A., Howell, R. M., Jefferies, J. L., Robison, L. L., Ness, K. K., Hudson, M. M., Chemaitilly, W., & Armstrong, G. T. (2024). Prediabetes and associated risk of cardiovascular events and chronic kidney disease among adult survivors of childhood cancer in the St. Jude Lifetime Cohort. Journal of Clinical Oncology, 42(9), 1031–1043. https://doi.org/10.1200/JCO.23.01005

Cromie, K. J., Murray, R. D., Ajjan, R. A., Hughes, N. F., Feltbower, R. G., & Glaser, A. W. (2025). Diabetes risk after treatment for childhood and young adult cancer. Diabetes Care, 48(4), 519–527. https://doi.org/10.2337/dc24-2171.

Downloads

Published

2026-05-30

How to Cite

Czyżak, K., Dąbek, K., Marzec, U., Cyrkler, A., Cieślak, N., Chodkowska, A., Rajca, E., Giza, A., Giza, P., & Wymoczył, K. (2026). OVERWEIGHT AND OBESITY IN CHILDHOOD CANCER SURVIVORS: A LITERATURE REVIEW. International Journal of Innovative Technologies in Social Science, 2(2(50). https://doi.org/10.31435/ijitss.2(50).2026.5104

Most read articles by the same author(s)