KETOGENIC DIET AS A POTENTIAL INTERVENTION FOR THE CURRENT OBESITY CRISIS AND THE ASSOCIATED TYPE 2 DIABETES
DOI:
https://doi.org/10.31435/ijitss.2(50).2026.5516Keywords:
Ultraprocessed, Obesity, Ketogenic Diet, Type 2 Diabetes, Body Fat Percentage, Weight LossAbstract
The worldwide obesity epidemic is making a turn for the worse with the ever-increasing consumption of ultraprocessed food through economically affected lifestyle changes. Obesity has become a leading cause of global mortality and morbidity. This review analyses the literature from the past 6 years to inspect the correlation between modern lifestyle, unprocessed diets, body weight changes affected by common diets, while taking into consideration the feasibility of adapting the ketogenic diet, considering both its advantageous and adverse effects on global obesity reduction, focusing more on patients who suffer from type 2 diabetes. Quantitative synthesis of variable types of research from meta-analyses, randomized trials, large-scale ecological studies from distinguished databases, evaluated the caloric net data, food processing classifications such as NOVA or HISS, energy expenditure equanimity, weight loss, glycemic control, lipids, and common adverse effects. The results show a strong statistical interdependence between the degree of consumption of ultraprocessed foods and higher body fat percentage, and reduced satiety, independent of caloric intake. Ketogenic diets that underwent evaluation demonstrated superior mean weight loss, improved glycated hemoglobin, reduced triglycerides, and increased HDL, compared with the control groups, with very low rates of ketoacidosis. The ketogenic diet is far from optimal, as it carries with it some risks, such as micronutrient deficiencies and drug interactions. A well-formulated ketogenic diet, with adherence to dietary guidelines, frequent morphological tests, and proper management of medication, offers an effective strategy in battling the global obesity and type 2 diabetes epidemic when properly monitored and supplemented.
References
McGrosky, A., Luke, A., Arab, L., Bedu-Addo, K., Bonomi, A. G., Bovet, P., Brage, S., Buchowski, M. S., Butte, N., Camps, S. G., Casper, R., Cummings, D. K., Das, S. K., Deb, S., Dugas, L. R., Ekelund, U., Forrester, T., Fudge, B. W., Gillingham, M., … IAEA DLW Database Consortium. (2025). Energy expenditure and obesity across the economic spectrum. Proceedings of the National Academy of Sciences of the United States of America, 122(29), Article e2420902122. https://doi.org/10.1073/pnas.2420902122
He, Q. X., Zhao, L., Tong, J. S., Liang, X. Y., Li, R. N., Zhang, P., & Liang, X. H. (2022). The impact of obesity epidemic on type 2 diabetes in children and adolescents: A systematic review and meta-analysis. Primary Care Diabetes, 16(6), 736–744. https://doi.org/10.1016/j.pcd.2022.09.006
Jiao, Y., Chen, X., Liu, L., Lu, Y., Gao, M., Wang, Q., Chi, X., & Mo, Y. (2025). Sex differences in ketogenic diet: Are men more likely than women to lose weight? Frontiers in Nutrition, 12, Article 1600927. https://doi.org/10.3389/fnut.2025.1600927
De La Motte, K. L., Campbell, J. L., & Zinn, C. (2024). Exploring consumption of ultra-processed foods and diet quality in the context of popular low carbohydrate and plant-based dietary approaches. Food Science & Nutrition, 12(11), 9651–9663. https://doi.org/10.1002/fsn3.4496
Zhou, C., Wang, M., Liang, J., He, G., & Chen, N. (2022). Ketogenic diet benefits to weight loss, glycemic control, and lipid profiles in overweight patients with type 2 diabetes mellitus: A meta-analysis of randomized controlled trials. International Journal of Environmental Research and Public Health, 19(16), Article 10429. https://doi.org/10.3390/ijerph191610429
Roberts, C. G. P., Athinarayanan, S. J., Ratner, R. E., & Umpierrez, G. E. (2025). Illnesses associated with ketosis including diabetic ketoacidosis during very low carbohydrate and ketogenic diets. Diabetes, Obesity and Metabolism, 27(5), 2531–2539. https://doi.org/10.1111/dom.16252
Li, J., He, W., Wu, Q., Qin, Y., Luo, C., Dai, Z., Long, Y., Yan, P., Huang, W., & Cao, L. (2025). Ketogenic diets and β-hydroxybutyrate in the prevention and treatment of diabetic kidney disease: Current progress and future perspectives. BMC Nephrology, 26, Article 127. https://doi.org/10.1186/s12882-025-04019-0
Churuangsuk, C., Catchpole, A., Talwar, D., Welsh, P., Sattar, N., Lean, M. E. J., & Combet, E. (2024). Low thiamine status in adults following low-carbohydrate/ketogenic diets: A cross-sectional comparative study of micronutrient intake and status. European Journal of Nutrition, 63(7), 2667–2679. https://doi.org/10.1007/s00394-024-03459-y
Jaeschke, R., Gajewski, P., & O’Byrne, P. M. (Eds.). (2019). McMaster textbook of internal medicine 2019/20. Empendium.
Zhou, X.-D., Chen, Q.-F., Yang, W., Zuluaga, M., Targher, G., Byrne, C. D., Valenti, L., Luo, F., Katsouras, C. S., Thaher, O., Misra, A., Ataya, K., Oviedo, R. J., Kong, A. P.-S., Alswat, K., Lonardo, A., Wong, Y. J., Abu-Abeid, A., Al Momani, H., … Zheng, M.-H. (2024). Burden of disease attributable to high body mass index: An analysis of data from the Global Burden of Disease Study 2021. EClinicalMedicine, 76, Article 102848. https://doi.org/10.1016/j.eclinm.2024.102848
Dicken, S. J., Jassil, F. C., Brown, A., Kalis, M., Stanley, C., Ranson, C., Ruwona, T., Qamar, S., Buck, C., Mallik, R., Hamid, N., Bird, J. M., Brown, A., Norton, B., Gandini Wheeler-Kingshott, C. A. M., Hamer, M., van Tulleken, C., Hall, K. D., Fisher, A., … Batterham, R. L. (2025). Ultraprocessed or minimally processed diets following healthy dietary guidelines on weight and cardiometabolic health: A randomized, crossover trial. Nature Medicine, 31(10), 3297–3308. https://doi.org/10.1038/s41591-025-03842-0
De La Motte, K. L., Campbell, J. L., & Zinn, C. (2024). Exploring consumption of ultra-processed foods and diet quality in the context of popular low carbohydrate and plant-based dietary approaches. Food Science & Nutrition, 12(11), 9651–9663. https://doi.org/10.1002/fsn3.4496
Lean, M. E. J., Leslie, W. S., Barnes, A. C., Brosnahan, N., Thom, G., McCombie, L., Peters, C., Zhyzhneuskaya, S., Al-Mrabeh, A., Hollingsworth, K. G., Rodrigues, A. M., Rehackova, L., Adamson, A. J., Sniehotta, F. F., Mathers, J. C., Ross, H. M., McIlvenna, Y., Stefanetti, R., Trenell, M. I., … Taylor, R. (2018). Primary care-led weight management for remission of type 2 diabetes (DiRECT): An open-label, cluster-randomised trial. The Lancet, 391(10120), 541–551. https://doi.org/10.1016/S0140-6736(17)33102-1
Palmer, R., Neiberg, R. H., Beavers, K. M., Kahn, S. E., Houston, D. K., Wagenknecht, L., Johnson, K. C., Pownall, H. J., Espeland, M. A., & Action for Health in Diabetes (Look AHEAD) Aging Study Group. (2025). Associations between decreases in adiposity and reductions in HbA1c and insulin use in the Look AHEAD cohort. Obesity, 33(3), 612–620. https://doi.org/10.1002/oby.24242
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Copyright (c) 2026 Krystian Andryszko, Marcelina Dymon, Daria Aleksandra Warzocha-Żurek, Agnieszka Szwed, Ewa Maria Polewczak-Karp, Natalia Ziemba-Furgała, Aleksandra Sołtys, Katarzyna Anna Borzęcka, Paulina Krysa, Katarzyna Wawrzonek
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