THE ROLE OF MYOGENIC DIFFERENTIATION ABERRATIONS IN THE PHYSICAL PERFORMANCE
DOI:
https://doi.org/10.31435/ijitss.2(50).2026.5591Keywords:
Myoblast Differentiation, Physical Performance, Epigenetics, Cell Cycle, MyogenesisAbstract
Physical performance is influenced by numerous factors, both congenital and non-congenital. Key determinants include diet, physical activity, lifestyle, and environmental exposure. It depends largely on the proper functioning of the musculoskeletal and cardiovascular systems.
Human myogenesis is a tightly regulated process that begins during prenatal development and continues throughout life. The key regulators of this process are myogenic regulatory factors (MRFs), a family of helix–loop–helix transcription factors. These factors cooperate with members of the myocyte enhancer factor 2 (MEF2) family to promote the transcription of muscle-specific genes. In addition, epigenetic mechanisms play a crucial role in regulating gene expression during myogenic differentiation and satellite cell activation. Cell-cycle regulators further contribute to myogenesis by controlling satellite cell proliferation and differentiation, thereby influencing muscle regeneration. Moreover, a wide range of bioactive compounds has been shown to modulate myogenesis through their effects on key regulatory pathways. These regulatory mechanisms may contribute to interindividual variability in physical performance. However, most of the available evidence is derived from in vitro studies, and its relevance to human physiology remains uncertain. Therefore, further research is required to better understand the role of these mechanisms in shaping physical performance. The aim of this review is to summarize current knowledge on the regulatory mechanisms of myogenesis and their role in physical performance. A narrative review of recent literature focusing on molecular and cellular mechanisms regulating myogenesis was conducted.
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Copyright (c) 2026 Filip Glista, Mikołaj Stepura, Jakub Najgeburski, Aleksandra Giernalczyk, Agnieszka Dąbrowska, Weronika Nawrocka, Mikołaj Jaszowski, Inez Michalska, Anna-Maria Grzeczka, Paula Żak, Patrycja Pietraszkiewicz, Zuzanna Taciak, Katarzyna Pinkowska, Zuzanna Korbel
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