OPTIMIZING THE SKIN BARRIER: A COMPREHENSIVE GUIDE TO SKINCARE IN ATOPIC DERMATITIS
DOI:
https://doi.org/10.31435/ijitss.2(50).2026.5904Keywords:
Atopic Dermatitis, Emollients, Pruritus, Skincare, AtopyAbstract
Introduction. Atopic Dermatitis (AD) is a complex, chronic, profoundly pruritic inflammatory dermatosis characterized by compromised epidermal barrier and relapsing-remitting course. While systemic therapies and targeted immunomodulators have revolutionized the management of moderate-to-severe disease presentations, the foundational pillar of AD management across all spectrums of severity remains the proactive restoration and maintenance of the stratum corneum. This comprehensive review summarizes clinical evidence regarding the pathophysiology of the atopic skin barrier, detailing the genetic implications of FLG loss-of-function mutations, the specific biochemical depletion of intercellular lipids (particularly ceramides), and the resultant microbiome dysbiosis driven by Staphylococcus aureus colonization.
Materials and Methods. A systematic, rigorous search of peer-reviewed literature was conducted to synthesize current, evidence-based practices regarding skin barrier optimization in Atopic Dermatitis. A comprehensive literature search was executed across major medical and scientific databases, primarily utilizing PubMed/MEDLINE, Google Scholar, the Cochrane Central Register of Controlled Trials and Embase. Data were extracted focusing on the biochemical properties of the skin barrier, the comparative efficacy of various emollient formulations, and the specific clinical outcomes related to proactive versus reactive treatment modalities. The extracted data were analyzed and structured to provide a cohesive guide that translates complex dermatological science into actionable clinical management strategies.
Results: The literature demonstrates that skin barrier dysfunction in Atopic Dermatitis is driven by FLG loss-of-function mutations, a distinct depletion of intercellular lipids (predominantly ceramides), and secondary Staphylococcus aureus microbiome dysbiosis. To counteract these defects, the evidence supports a foundational, multi-pronged barrier management approach. Successful strategies include evidence-based therapeutic bathing protocols, the precise application of targeted emollient classes, and the utilization of the "soak and smear" technique to lock in moisture. Furthermore, integrating these interventions with adjunctive pharmacotherapy, strict trigger avoidance, and comprehensive patient-centered education significantly enhances overall treatment efficacy and barrier integrity.
Conclusions: Proactive, continuous maintenance of the stratum corneum remains the indispensable foundation of AD management, regardless of disease severity. Rather than relying on reactive treatments for acute flare-ups, clinicians must shift toward a holistic paradigm of continuous barrier optimization. This proactive strategy is essential not only for managing structural and microbial skin defects but also for potentially arresting the atopic march and alleviating the profound psychosocial burden carried by AD patients.
References
Al, B., et al. (2025). Subclinical inflammation precedes atopic dermatitis relapses. Journal of Allergy and Clinical Immunology, 155(3), 033. https://doi.org/10.1016/j.jaci.2025.03.033
Ananthapadmanabhan, K. P., Moore, D. J., Subramanyan, K., Misra, M., & Meyer, F. (2004). Cleansing without compromise: The impact of cleansers on the skin barrier and the technology of mild cleansing. Dermatologic Therapy, 17(S1), 16–25. https://doi.org/10.1111/j.1396-0296.2004.04s1002.x
Barnes, T. M., & Greive, K. A. (2013). Use of bleach baths for the treatment of infected atopic eczema. Australasian Journal of Dermatology, 54(4), 251–258. https://doi.org/10.1111/ajd.12015
Bass, A., Anderson, K., & Feldman, S. (2015). Interventions to increase treatment adherence in pediatric atopic dermatitis: A systematic review. Journal of Clinical Medicine, 4(2), 231–242. https://doi.org/10.3390/jcm4020231
Benson, H. A. E., Grice, J. E., Mohammed, Y., Namjoshi, S., & Roberts, M. S. (2019). Topical and transdermal drug delivery: From simple potions to smart technologies. Current Drug Delivery, 16(5), 444–460. https://doi.org/10.2174/1567201816666190201143457
Boer, M., Duchnik, E., Maleszka, P., & Marchlewicz, M. (2018). Research techniques made simple: Transepidermal water loss measurement as a research tool. Journal of Investigative Dermatology, 138(11), 2295–2300.e1. https://doi.org/10.1016/j.jid.2018.09.001
Bonamonte, D., Filoni, A., Vestita, M., Romita, P., Foti, C., & Angelini, G. (2019). The role of the environmental risk factors in the pathogenesis and clinical outcome of atopic dermatitis. BioMed Research International, 2019, 2450605. https://doi.org/10.1155/2019/2450605
Boyce, J. A., Assa'ad, A., Burks, A. W., Jones, S. M., Sampson, H. A., Sicherer, S. H., Plaut, M., Tinkle, S. S., Byrd-Bredbenner, C., Fizer, E. S., Fineman, S. M., Furuta, G. T., Greenhawt, M. J., Li, J. T., Lemanske, R. F., Jr., Schneider, L. C., Smith, C., Staab, R., Teuber, S. S., & Schwaninger, J. M. (2010). Guidelines for the diagnosis and management of food allergy in the United States: Report of the NIAID-sponsored expert panel. Journal of Allergy and Clinical Immunology, 126(6 Suppl), S1–S58. https://doi.org/10.1016/j.jaci.2010.10.007
Byrd, A. L., Belkaid, Y., & Segre, J. A. (2018). The human skin microbiome. Nature Reviews Microbiology, 16(3), 143–155. https://doi.org/10.1038/nrmicro.2017.157
Callender, V. D., Alexis, A. F., Stein Gold, L. F., Lebwohl, M. G., Paller, A. S., Desai, S. R., Tan, H., Ports, W. C., Zielinski, M. A., & Tallman, A. M. (2019). Efficacy and safety of crisaborole ointment, 2%, for the treatment of mild-to-moderate atopic dermatitis across racial and ethnic groups. American Journal of Clinical Dermatology, 20(5), 711–723. https://doi.org/10.1007/s40257-019-00450-w
Carr, W. W. (2013). Topical calcineurin inhibitors for atopic dermatitis: Review and treatment recommendations. Paediatric Drugs, 15(4), 303–310. https://doi.org/10.1007/s40272-013-0013-9
Christou, D., Stevanovic, K., Evers, S., Weide, M., & Zuberbier, T. (2024). Evaluating the impact of laundry detergents on the skin microbiome of atopic dermatitis patients—A clinical study. Health Science Reports, 7(12), e70261. https://doi.org/10.1002/hsr2.70261
Danby, S. G., AlEnezi, T., Sultan, A., Lavender, T., Chittock, J., Brown, K., & Cork, M. J. (2013). Effect of olive and sunflower seed oil on the adult skin barrier: Implications for neonatal skin care. Pediatric Dermatology, 30(1), 42–50. https://doi.org/10.1111/j.1525-1470.2012.01865.x
Devillers, A. C. A., & Oranje, A. P. (2012). Wet-wrap treatment in children with atopic dermatitis: A practical guideline. Pediatric Dermatology, 29(1), 24–27. https://doi.org/10.1111/j.1525-1470.2011.01691.x
Dharmage, S. C., Lowe, A. J., Matheson, M. C., Burgess, J. A., Allen, K. J., & Abramson, M. J. (2013). Atopic dermatitis and the atopic march revisited. Allergy, 69(1), 17–27. https://doi.org/10.1111/all.12268
Du Toit, G., Roberts, G., Sayre, P. H., Bahnson, H. T., Radulovic, S., Santos, A. F., Brough, H. A., Phippard, D., Basting, M., Feeney, M., Turcanu, V., Sever, M. L., Gomez Lorenzo, M., Plaut, M., & Lack, G. (2015). Randomized trial of peanut consumption in infants at risk for peanut allergy. The New England Journal of Medicine, 372(9), 803–813. https://doi.org/10.1056/NEJMoa1414850
Eichenfield, L. F., Tom, W. L., Chamlin, S. L., Feldman, S. R., Hanifin, J. M., Simpson, E. L., Berger, T. G., Bergman, J. N., Cohen, D. E., Cooper, K. D., Cordoro, K. M., Davis, D. M., Krol, A., Margolis, D. J., Paller, A. S., Schwarzenberger, K., Silverman, R. A., Williams, H. C., Elmets, C. A., … Sidbury, R. (2014). Guidelines of care for the management of atopic dermatitis: Part 1: Diagnosis and assessment of atopic dermatitis. Journal of the American Academy of Dermatology, 70(2), 338–351. https://doi.org/10.1016/j.jaad.2013.10.010
Elias, P. M. (2014). Lipid abnormalities and lipid-based repair strategies in atopic dermatitis. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 1841(3), 323–330. https://doi.org/10.1016/j.bbalip.2013.10.001
Fleischer, D. M., Spergel, J. M., Assa'ad, A. H., & Pongracic, J. A. (2013). Primary prevention of allergic disease through nutritional interventions. The Journal of Allergy and Clinical Immunology: In Practice, 1(1), 29–36. https://doi.org/10.1016/j.jaip.2012.09.003
Fransen, L., et al. (n.d.). Contact allergy to lanolin: Temporal changes in prevalence and association with atopic dermatitis. Contact Dermatitis. https://doi.org/10.1111/cod.12872
Fransen, M., Overgaard, L. E. K., Johansen, J. D., & Thyssen, J. P. (2017). Contact allergy to lanolin: Temporal changes in prevalence and association with atopic dermatitis. Contact Dermatitis, 78(1), 70–75. https://doi.org/10.1111/cod.12872
Frazier, W., & Bhardwaj, N. (2020). Atopic dermatitis: Diagnosis and treatment. American Family Physician, 101(10), 590–598.
González-López, G., Ceballos-Rodríguez, R. M., González-López, J. J., Feito Rodríguez, M., & Herranz-Pinto, P. (2017). Efficacy and safety of wet wrap therapy for patients with atopic dermatitis: A systematic review and meta-analysis. British Journal of Dermatology, 177(3), 688–695. https://doi.org/10.1111/bjd.15165
Hartmann, D., Retamal, C., & Valenzuela, F. (2025). Precision medicine and treat-to-target approach in atopic dermatitis: Enhancing personalized care and outcomes. Anais Brasileiros de Dermatologia. Advance online publication. https://doi.org/10.1016/j.abd.2025.501135
Huang, J. T., Abrams, M., Tlougan, B., Rademaker, A., & Paller, A. S. (2009). Treatment of Staphylococcus aureus colonization in atopic dermatitis decreases disease severity. Pediatrics, 123(5), e808–e814. https://doi.org/10.1542/peds.2008-2217
Irvine, A. D., McLean, W. H. I., & Leung, D. Y. M. (2011). Filaggrin mutations associated with skin and allergic diseases. New England Journal of Medicine, 365(14), 1315–1327. https://doi.org/10.1056/NEJMra1011040
Jang, H., Matsuda, A., Jung, K., Karasawa, K., Matsuda, K., Oida, K., Ishizaka, S., Ahn, G., Amagai, Y., Moon, C., Kim, S.-H., Arkwright, P. D., Takamori, K., Matsuda, H., & Tanaka, A. (2016). Skin pH is the master switch of kallikrein 5-mediated skin barrier destruction in a murine atopic dermatitis model. Journal of Investigative Dermatology, 136(1), 127–135. https://doi.org/10.1038/JID.2015.363
Janssens, M., van Smeden, J., Gooris, G. S., Bras, W., Portale, G., Caspers, P. J., Vreeken, R. J., Hankemeier, T., Kezic, S., Wolterbeek, R., Lavrijsen, A. P., & Bouwstra, J. A. (2012). Increase in short-chain ceramides correlates with an altered lipid organization and decreased barrier function in atopic eczema patients. Journal of Lipid Research, 53(12), 2755–2766. https://doi.org/10.1194/jlr.P030338
Khosravi, A., Glińska, J., & Barańska-Rybak, W. (2024). Sleep efficiency and neurocognitive decline in atopic dermatitis: A systematic review. Acta Dermato-Venereologica, 104. https://doi.org/10.2340/actadv.v104.40459
Kolbe, L., Immeyer, J., Batzer, J., Wensorra, U., Dieck, K. T., Mundt, C., Wolber, R., Stäb, F., Schönrock, U., Ceilley, R. I., & Wenck, H. (2006). Anti-inflammatory efficacy of Licochalcone A: Correlation of clinical potency and in vitro effects. Archives of Dermatological Research, 298(1), 23–30. https://doi.org/10.1007/s00403-006-0654-4
Koppelhus, U., Poulsen, J., Grunnet, N., Deleuran, M. S., & Obitz, E. (2014). Cyclosporine and extracorporeal photopheresis are equipotent in treating severe atopic dermatitis: A randomized cross-over study comparing two efficient treatment modalities. Frontiers in Medicine, 1, Article 33. https://doi.org/10.3389/fmed.2014.00033
Kozłowska, K., & Mędraś, M. (2025). Genetic factors predisposing to atopic dermatitis: Selected genes related to the skin barrier and immune response. Dermatology Review/Przegląd Dermatologiczny, 112(1), 1–13. https://doi.org/10.5114/dr.2025.147775
Krejci-Manwaring, J., Tusa, M. G., Carroll, C., Camacho, F., Kaur, M., Carr, D., Fleischer, A. B., Jr., Balkrishnan, R., & Feldman, S. R. (2007). Stealth monitoring of adherence to topical medication: Adherence is very poor in children with atopic dermatitis. Journal of the American Academy of Dermatology, 56(2), 211–216. https://doi.org/10.1016/j.jaad.2006.05.073
Langan, S. M., Irvine, A. D., & Weidinger, S. (2020). Atopic dermatitis. The Lancet, 396(10247), 345–360. https://doi.org/10.1016/S0140-6736(20)31286-1
Leung, D. Y. M. (2000). Atopic dermatitis: New insights and opportunities for therapeutic intervention. Journal of Allergy and Clinical Immunology, 105(5), 860–876. https://doi.org/10.1067/mai.2000.106484
Leung, T. H., Zhang, L. F., Wang, J., Ning, S., Knox, S. J., & Kim, S. K. (2013). Topical hypochlorite ameliorates NF-κB-mediated skin diseases in mice. Journal of Clinical Investigation, 123(12), 5361–5370. https://doi.org/10.1172/jci70895
Long, C. C., & Finlay, A. Y. (1991). The finger-tip unit—a new practical measure. Clinical and Experimental Dermatology, 16(6), 444–447. https://doi.org/10.1111/j.1365-2230.1991.tb01232.x
Mack, M. R., & Kim, B. S. (2018). The itch–scratch cycle: A neuroimmune perspective. Trends in Immunology, 39(12), 980–991. https://doi.org/10.1016/j.it.2018.10.001
Man, M. Q., Feingold, K. R., & Elias, P. M. (1993). Exogenous lipids influence permeability barrier recovery in acetone-treated murine skin. Archives of Dermatology, 129(6), 728–738. https://doi.org/10.1001/archderm.1993.01680270068010
Mehta, A. B., Nadkarni, N. J., Patil, S. P., Godse, K. V., Gautam, M., & Agarwal, S. (2016). Topical corticosteroids in dermatology. Indian Journal of Dermatology, Venereology, and Leprology, 82(4), 371–378. https://doi.org/10.4103/0378-6323.178903
Mijaljica, D., Spada, F., & Harrison, I. P. (2022). Skin cleansing without or with compromise: Soaps and syndets. Molecules, 27(6), 2010. https://doi.org/10.3390/molecules27062010
Murota, H., Yamaga, K., Ono, E., & Katayama, I. (2018). Sweat in the pathogenesis of atopic dermatitis. Allergology International, 67(4), 455–459. https://doi.org/10.1016/j.alit.2018.06.003
Nankervis, T. N., Baurecht, H., Montgomery, A. A., Thomas, K. S., Weidinger, S., & Apfelbacher, C. (2015). House dust mite reduction and avoidance measures for treating eczema. Cochrane Database of Systematic Reviews, 2015(1), CD008426. https://doi.org/10.1002/14651858.CD008426.pub2
Nutten, S. (2015). Atopic dermatitis: Global epidemiology and risk factors. Annals of Nutrition & Metabolism, 66(Suppl. 1), 8–16. https://doi.org/10.1159/000370220
Owji, S., Caldas, S. A., & Ungar, B. (2022). Management of atopic dermatitis: Clinical utility of ruxolitinib. Journal of Asthma and Allergy, 15, 1527–1537. https://doi.org/10.2147/JAA.S342051
Pagliaro, M., Pecoraro, L., Stefani, C., Pieropan, S., Piacentini, G., & Pietrobelli, A. (2024). Bathing in atopic dermatitis in pediatric age: Why, how and when. Pediatric Reports, 16(1), 57–68. https://doi.org/10.3390/pediatric16010006
Panico, A., Serio, F., Bagordo, F., Grassi, T., Idolo, A., De Giorgi, M., Guido, M., Congedo, M., & De Donno, A. (2019). Skin safety and health prevention: An overview of chemicals in cosmetic products. Journal of Preventive Medicine and Hygiene, 60(1), E50–E57. https://doi.org/10.15167/2421-4248/jpmh2019.60.1.1080
Patel, N., & Feldman, S. R. (2017). Adherence in atopic dermatitis. Advances in Experimental Medicine and Biology, 139–159. https://doi.org/10.1007/978-3-319-64804-0_12
Piquero-Casals, J., Morgado-Carrasco, D., Granger, C., Trullàs, C., Jesús-Silva, A., & Krutmann, J. (2021). Urea in dermatology: A review of its emollient, moisturizing, keratolytic, skin barrier enhancing and antimicrobial properties. Dermatology and Therapy, 11(6), 1905–1915. https://doi.org/10.1007/s13555-021-00611-y
Powell, K., Le Roux, E., Banks, J. P., & Ridd, M. J. (2018). Developing a written action plan for children with eczema: A qualitative study. British Journal of General Practice, 68(667), e81–e89. https://doi.org/10.3399/bjgp17X693617
Prakoeswa, C. R. S., Huda, B. K. N., Indrawati, D., Umborowati, M. A., Anggraeni, S., Damayanti, Murtiastutik, D., & Kerob, D. (2025). Effectiveness and tolerability of an emollient “plus” compared to urea 10% in patients with mild-to-moderate atopic dermatitis. Journal of Cosmetic Dermatology, 24(2), e70051. https://doi.org/10.1111/jocd.70051
Rachalewski, M., Pasikowska-Piwko, M., Dębowska, R., Marczak, I., Lendzion, K., Godziątkowski, H., Czarnomysy, R., Rogiewicz, K., & Eris, I. (2024). Biocompatibility and post-marketing surveillance study of emollient plus medical device cream containing oligofructans from Ophiopogon japonicus and acetyl heptapeptide-4 in atopic dermatitis skin care. Cosmetics, 11(4), 136. https://doi.org/10.3390/cosmetics11040136
Rawlings, A. V., & Harding, C. R. (2004). Moisturization and skin barrier function. Dermatologic Therapy, 17(Suppl. 1), 43–48. https://doi.org/10.1111/j.1396-0296.2004.04s1005.x
Rubin, C. B., & Brod, B. (2019). Natural does not mean safe—The dirt on clean beauty products. JAMA Dermatology, 155(12), 1344–1345. https://doi.org/10.1001/jamadermatol.2019.2724
Schmid-Wendtner, M. H., & Korting, H. C. (2006). The pH of the skin surface and its impact on the barrier function. Skin Pharmacology and Physiology, 19(6), 296–302. https://doi.org/10.1159/000094670
Schneider, L., Tilles, S., Lio, P., Boguniewicz, M., Blauvelt, A., Lebwohl, M. G., & American Academy of Dermatology. (2014). Guidelines of care for the management of atopic dermatitis: Section 3. Management and treatment with phototherapy and systemic agents. Journal of the American Academy of Dermatology, 71(2), 332–349. https://doi.org/10.1016/j.jaad.2014.03.030
Sethi, A., Kaur, T., Malhotra, S. K., & Gambhir, M. L. (2016). Moisturizers: The slippery road. Indian Journal of Dermatology, 61(3), 279–287. https://doi.org/10.4103/0019-5154.182427
Simpson, E. L., Papp, K. A., Blauvelt, A., Chu, C. Y., Danby, S. G., Eichenfield, L. F., Hebert, A. A., Kuligowski, M. E., Venturanza, M. E., & Silverberg, J. I. (2024). Ruxolitinib cream monotherapy improved symptoms and quality of life in adults and adolescents with mild-to-moderate atopic dermatitis: Patient-reported outcomes from two phase III studies. American Journal of Clinical Dermatology. Advance online publication. https://doi.org/10.1007/s40257-024-00901-z
Sidbury, R., Alikhan, A., Bercovitch, L., Cohen, D. E., Darr, J. M., Drucker, A. M., Eichenfield, L. F., Frazer-Green, L., Paller, A. S., Schwarzenberger, K., Silverberg, J. I., Singh, A. M., Wu, P. A., & Davis, D. M. R. (2023). Executive summary: American Academy of Dermatology guidelines of care for the management of atopic dermatitis in adults with topical therapies. Journal of the American Academy of Dermatology, 89(1), 128–129. https://doi.org/10.1016/j.jaad.2022.08.068
Su, J. C., Dailey, R., Zallmann, M., Leins, E., Taresch, L., Donath, S., Heah, S. S., & Lowe, A. J. (2017). Determining effects of superfine sheep wool in infantile eczema (DESSINE): A randomized paediatric crossover study. British Journal of Dermatology, 177(1), 125–133. https://doi.org/10.1111/bjd.15376
Tai, V. W. T., Oh, L. J. J., Yew, Y. W., & Li, B. K. (2026). Do medication beliefs influence adherence to topical therapies in patients with atopic dermatitis? JEADV Clinical Practice, 2(1), 1–13. https://doi.org/10.1002/jvc2.70295
Thaçi, D., Reitamo, S., Gonzalez Ensenat, M. A., Moss, C., Boccaletti, V., Cainelli, T., van der Valk, P., Buckova, H., Sebastian, M., Schuttelaar, M. L., & Ruzicka, T. (2008). Proactive disease management with 0.03% tacrolimus ointment for children with atopic dermatitis: Results of a randomized, multicentre, comparative study. British Journal of Dermatology, 159(6), 1348–1356. https://doi.org/10.1111/j.1365-2133.2008.08813.x
Thomas, S. (2008). The role of dressings in the treatment of moisture-related skin damage. World Wide Wounds. http://www.worldwidewounds.com/2008/march/Thomas/Maceration-and-the-role-of-dressings.html
Totté, J. E., van der Feltz, W. T., Hennekam, M., van Belkum, A., van Zuuren, E. J., & Pasmans, S. G. (2016). Prevalence and odds of Staphylococcus aureus carriage in atopic dermatitis: A systematic review and meta-analysis. British Journal of Dermatology, 175(4), 687–695. https://doi.org/10.1111/bjd.14566
Wollenberg, A., Christen-Zäch, S., Taieb, A., Paul, C., Thyssen, J. P., de Bruin-Weller, M., Vestergaard, C., Seneschal, J., Werfel, T., Cork, M. J., Kunz, B., Fölster-Holst, R., Trzeciak, M., Darsow, U., Szalai, Z., Deleuran, M., von Kobyletzki, L., Barbarot, S., Heratizadeh, A., … Ring, J. (2020). ETFAD/EADV Eczema Task Force 2020 position paper on diagnosis and treatment of atopic dermatitis in adults and children. Journal of the European Academy of Dermatology and Venereology, 34(12), 2717–2744. https://doi.org/10.1111/jdv.16892
Wollenberg, A., Kinberger, M., Arents, B., Aszodi, N., Avila Valle, G., Barbarot, S., Bieber, T., Brough, H. A., Calzavara Pinton, P., Christen-Zäch, S., Deleuran, M., Dittmann, M., Dressler, C., Fink-Wagner, A. H., Fosse, N., Gáspár, K., Gerbens, L., Gieler, U., Girolomoni, G., … Flohr, C. (2022). European guideline (EuroGuiDerm) on atopic eczema – part II: Non-systemic treatments and treatment recommendations for special AE patient populations. Journal of the European Academy of Dermatology and Venereology, 36(11), 1904–1926. https://doi.org/10.1111/jdv.18429
Zhang, N., Chi, H., Jin, Q., Sun, M., Zhao, Y., & Song, P. (2025). Prevalence of sleep disorders in atopic dermatitis: A systematic review and meta-analysis. Archives of Dermatological Research, 317(1), 668. https://doi.org/10.1007/s00403-025-04176-0
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Copyright (c) 2026 Julia Kret, Adrianna Zabiegałowska, Michał Szpunar, Lilianna Zielińska, Jan Gdula, Paulina Bigda, Aleksander Sadkowski, Oliwer Muller, Jagoda Pałubska, Aleksandra Wyrostkiewicz, Anna Wojtala, Stanisław Rutz, Zuzanna Rafałowska, Magda Buśko
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