TRANSCUTANEOUS ELECTRICAL NERVE STIMULATION AS AN ADJUNCTIVE INTERVENTION FOR PAIN, FATIGUE, AND FUNCTION IN FIBROMYALGIA: A LITERATURE REVIEW
DOI:
https://doi.org/10.31435/ijitss.3(51).2026.6052Keywords:
Transcutaneous Electrical Nerve Stimulation, TENS, Fibromyalgia, Movement-evoked Pain, Fatigue, Clinical TolerabilityAbstract
Introduction: Fibromyalgia is a chronic pain disorder characterized by widespread pain, fatigue, sleep disturbances, cognitive impairment, and reduced quality of life. Current management emphasizes patient education and non-pharmacological interventions, particularly physical activity. Transcutaneous electrical nerve stimulation (TENS) may be relevant as an adjunctive approach because of its potential to modulate pain mechanisms and support activity tolerance.
Methodology: A structured search of the PubMed database was conducted to identify studies evaluating TENS in fibromyalgia, published between 2011 and 2026. Randomized controlled trials were prioritized, particularly those assessing pain, movement-evoked pain, fatigue, physical function, quality of life, and clinical tolerability. Clinical trials, observational studies, secondary analyses, systematic reviews, and meta-analyses were also included when clinically relevant. Only English-language free full-text articles were included. The selected publications were analyzed qualitatively.
Results: The most consistent findings were observed for reductions in movement-evoked pain and fatigue, particularly when conventional TENS was applied regularly at a strong but comfortable intensity during physical activity. Effects on rest pain, objective physical function, activity levels, and quality of life were less consistent. Secondary analyses suggested that early response to TENS may help predict later clinical benefit. TENS was generally well tolerated, with mostly mild adverse events. Related transcutaneous neuromodulation approaches showed variable outcomes.
Conclusions: TENS may serve as an adjunctive non-pharmacological intervention for patients with fibromyalgia, especially for movement-evoked pain and fatigue. Further rigorously designed studies are needed to optimize stimulation protocols and identify patients most likely to benefit.
References
Arnold, L. M., Bennett, R. M., Crofford, L. J., Dean, L. E., Clauw, D. J., Goldenberg, D. L., Fitzcharles, M.-A., Paiva, E. S., Staud, R., Sarzi-Puttini, P., Buskila, D., & Macfarlane, G. J. (2019). AAPT diagnostic criteria for fibromyalgia. The Journal of Pain, 20(6), 611–628. https://doi.org/10.1016/j.jpain.2018.10.008
Siracusa, R., Paola, R. D., Cuzzocrea, S., & Impellizzeri, D. (2021). Fibromyalgia: Pathogenesis, mechanisms, diagnosis and treatment options update. International Journal of Molecular Sciences, 22(8), 3891. https://doi.org/10.3390/ijms22083891
Wolfe, F., Clauw, D. J., Fitzcharles, M.-A., Goldenberg, D. L., Häuser, W., Katz, R. L., Mease, P. J., Russell, A. S., Russell, I. J., & Walitt, B. (2016). 2016 Revisions to the 2010/2011 fibromyalgia diagnostic criteria. Seminars in Arthritis and Rheumatism, 46(3), 319–329. https://doi.org/10.1016/j.semarthrit.2016.08.012
Macfarlane, G. J., Kronisch, C., Dean, L. E., Atzeni, F., Häuser, W., Fluß, E., Choy, E., Kosek, E., Amris, K., Branco, J., Dincer, F., Leino-Arjas, P., Longley, K., McCarthy, G. M., Makri, S., Perrot, S., Sarzi-Puttini, P., Taylor, A., & Jones, G. T. (2017). EULAR revised recommendations for the management of fibromyalgia. Annals of the Rheumatic Diseases, 76(2), 318–328. https://doi.org/10.1136/annrheumdis-2016-209724
Johnson, M. I., Claydon, L. S., Herbison, G. P., Jones, G., & Paley, C. A. (2017). Transcutaneous electrical nerve stimulation (TENS) for fibromyalgia in adults. Cochrane Database of Systematic Reviews, 10(10), CD012172. https://doi.org/10.1002/14651858.CD012172.pub2
Dailey, D. L., Rakel, B. A., Vance, C. G. T., Liebano, R. E., Amrit, A. S., Bush, H. M., Lee, K. S., Lee, J. E., & Sluka, K. A. (2013). Transcutaneous electrical nerve stimulation reduces pain, fatigue and hyperalgesia while restoring central inhibition in primary fibromyalgia. Pain, 154(11), 2554–2562. https://doi.org/10.1016/j.pain.2013.07.043
Dailey, D. L., Vance, C. G. T., Rakel, B. A., Zimmerman, M. B., Embree, J., Merriwether, E. N., Geasland, K. M., Chimenti, R., Williams, J. M., Golchha, M., Crofford, L. J., & Sluka, K. A. (2020). Transcutaneous electrical nerve stimulation reduces movement‐evoked pain and fatigue: A randomized, controlled trial. Arthritis & Rheumatology, 72(5), 824–836. https://doi.org/10.1002/art.41170
Carbonario, F., Matsutani, L. A., Yuan, S. L. K., & Marques, A. P. (2013). Effectiveness of high-frequency transcutaneous electrical nerve stimulation at tender points as adjuvant therapy for patients with fibromyalgia. European Journal of Physical and Rehabilitation Medicine, 49(2), 197–204.
Dailey, D. L., Vance, C. G. T., Van Gorp, B. J., Johnson, E. M., Post, A. A., Chimenti, R. L., Vance, K. G., Franck, C., Sault, J., Yarasir, E., Reisinger, H. S., Anderson, A., Anderson, J., Capelle, R., Crouch, A., Donatelle, J., Kaster, D., Kepros, T., Nicklies, E., … Clinician Group. (2026). Transcutaneous electrical nerve stimulation and pain with movement in people with fibromyalgia: A cluster randomized clinical trial. JAMA Network Open, 9(3), e262450. https://doi.org/10.1001/jamanetworkopen.2026.2450
Jamison, R. N., Edwards, R. R., Curran, S., Wan, L., Ross, E. L., Gilligan, C. J., & Gozani, S. N. (2021). Effects of wearable transcutaneous electrical nerve stimulation on fibromyalgia: A randomized controlled trial. Journal of Pain Research, 14, 2265–2282. https://doi.org/10.2147/JPR.S316371
Vance, C. G., Zimmerman, M. B., Dailey, D. L., Rakel, B. A., Geasland, K. M., Chimenti, R. L., Williams, J. M., Golchha, M., Crofford, L. J., & Sluka, K. A. (2021). Reduction in movement-evoked pain and fatigue during initial 30-minute TENS treatment predicts TENS responders in women with fibromyalgia. Pain, 162(5), 1545–1555. https://doi.org/10.1097/j.pain.0000000000002144
Dailey, D. L., Vance, C. G. T., Chimenti, R., Rakel, B. A., Zimmerman, M. B., Williams, J. M., Sluka, K. A., & Crofford, L. J. (2022). The influence of opioids on transcutaneous electrical nerve stimulation effects in women with fibromyalgia. The Journal of Pain, 23(7), 1268–1281. https://doi.org/10.1016/j.jpain.2022.02.008
Berardi, G., Dailey, D. L., Chimenti, R., Merriwether, E., Vance, C. G. T., Rakel, B. A., Crofford, L. J., & Sluka, K. A. (2024). Influence of transcutaneous electrical nerve stimulation (TENS) on pressure pain thresholds and conditioned pain modulation in a randomized controlled trial in women with fibromyalgia. The Journal of Pain, 25(6), 104452. https://doi.org/10.1016/j.jpain.2023.12.009
Yüksel, M., Ayaş, Ş., Cabıoğlu, M. T., Yılmaz, D., & Cabıoğlu, C. (2019). Quantitative data for transcutaneous electrical nerve stimulation and acupuncture effectiveness in treatment of fibromyalgia syndrome. Evidence-Based Complementary and Alternative Medicine, 2019, 9684649. https://doi.org/10.1155/2019/9684649
Eken, A., Kara, M., Baskak, B., Baltacı, A., & Gökçay, D. (2018). Differential efficiency of transcutaneous electrical nerve stimulation in dominant versus nondominant hands in fibromyalgia: Placebo-controlled functional near-infrared spectroscopy study. Neurophotonics, 5(1), 011005. https://doi.org/10.1117/1.NPh.5.1.011005
Mattar, J. G., Chalah, M. A., Ouerchefani, N., Sorel, M., Le Guilloux, J., Lefaucheur, J., Abi Lahoud, G. N., & Ayache, S. S. (2025). The effect of the EXOPULSE Mollii Suit on pain and fibromyalgia‐related symptoms—A randomized sham‐controlled crossover trial. European Journal of Pain, 29(2), e4729. https://doi.org/10.1002/ejp.4729
Sarı, İ. F., İlhanlı, İ., Mızrak, T., Kulaklı, F., & Kasap, Z. (2023). The effect of transcutaneous posterior tibial nerve stimulation on pain and quality of life in patients with fibromyalgia: A single-blind, randomized controlled trial. Journal of Clinical Medicine, 12(15), 4989. https://doi.org/10.3390/jcm12154989
Paccione, C. E., Stubhaug, A., Diep, L. M., Rosseland, L. A., & Jacobsen, H. B. (2022). Meditative-based diaphragmatic breathing vs. vagus nerve stimulation in the treatment of fibromyalgia—A randomized controlled trial: Body vs. machine. Frontiers in Neurology, 13, 1030927. https://doi.org/10.3389/fneur.2022.1030927
Lommano, M. G., Farah, S., Bianchi, B., Risa, A. M., Sarzi-Puttini, P., Salaffi, F., & Di Carlo, M. (2026). Non-invasive auricular vagus nerve stimulation in fibromyalgia: Impacts on autonomic function, central sensitization and pain catastrophizing. Joint Bone Spine, 93(1), 105966. https://doi.org/10.1016/j.jbspin.2025.105966
Salazar, A. P. D. S., Stein, C., Marchese, R. R., Plentz, R. D. M., & Pagnussat, A. D. S. (2017). Electric stimulation for pain relief in patients with fibromyalgia: A systematic review and meta-analysis of randomized controlled trials. Pain Physician, 20(2), 15–25.
Honda, Y., Sakamoto, J., Hamaue, Y., Kataoka, H., Kondo, Y., Sasabe, R., Goto, K., Fukushima, T., Oga, S., Sasaki, R., Tanaka, N., Nakano, J., & Okita, M. (2018). Effects of physical-agent pain relief modalities for fibromyalgia patients: A systematic review and meta-analysis of randomized controlled trials. Pain Research & Management, 2018, 2930632. https://doi.org/10.1155/2018/2930632
Downloads
Published
Issue
Section
License
Copyright (c) 2026 Julia Marek, Aleksandra Wiśniewska , Izabela Czerny, Szymon Daniszewski

This work is licensed under a Creative Commons Attribution 4.0 International License.
All articles are published in open-access and licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0). Hence, authors retain copyright to the content of the articles.
CC BY 4.0 License allows content to be copied, adapted, displayed, distributed, re-published or otherwise re-used for any purpose including for adaptation and commercial use provided the content is attributed.

