HUMAN PAPILLOMAVIRUS (HPV): CURRENT STRATEGIES FOR THE PREVENTION AND TREATMENT OF PRECANCEROUS LESIONS

Wiktor Śliwiński; Jakub Mazur; Mateusz Kosowski; Jakub Marciniak; Daniel Chołuj; Karolina Zarówna; Weronika Pura; Dominika Matecka; Beata Huszcza

doi:10.31435/ijitss.3(51).2026.6560

Authors

Wiktor Śliwiński The Independent Public Healthcare Institution of the Ministry of the Interior and Administration in Łódź, Północna 42 Street, 91–425 Łódź, Poland https://orcid.org/0009-0003-3584-9776
Jakub Mazur Voivodeship Combined Hospital in Kielce 45 Grunwaldzka Street, 25-736 Kielce, Poland https://orcid.org/0009-0005-1089-9210
Mateusz Kosowski Independent Public Healthcare Institution in Koło 25 Księcia Józefa Poniatowskiego Street, 62-600 Koło, Poland https://orcid.org/0009-0001-0811-5326
Jakub Marciniak University Clinical Hospital No. 2 of the Medical University of Łódź 113 Żeromskiego Street, 90-549 Łódź, Poland https://orcid.org/0009-0004-5675-6963
Daniel Chołuj The Independent Public Healthcare Institution of the Ministry of the Interior and Administration in Łódź Północna 42 Street, 91–425 Łódź, Poland https://orcid.org/0009-0009-1445-6336
Karolina Zarówna District Hospital Complex in Oleśnica Armii Krajowej Street, 56-400 Oleśnica, Poland https://orcid.org/0009-0003-6066-7667
Weronika Pura The Independent Public Healthcare Institution of the Ministry of the Interior and Administration in Łódź Północna 42 Street, 91–425 Łódź, Poland https://orcid.org/0009-0007-2889-667X
Dominika Matecka Józef Struś Municipal Hospital, a Multispecialty Medical Centre in Poznań Szwajcarska Street, 61-285 Poznań, Poland https://orcid.org/0009-0000-4644-5943
Beata Huszcza Dr. Karol Jonscher Municipal Medical Center in Lodz, Milionowa Street 14, 93-113 Łódź, Poland https://orcid.org/0009-0002-2168-5275

DOI:

https://doi.org/10.31435/ijitss.3(51).2026.6560

Keywords:

Cervical Intraepithelial Neoplasia, Human Papillomavirus, Photodynamic Therapy, Cancer Preventon

Abstract

Background: Human papillomavirus (HPV) infection is the primary etiology of cervical cancer and its immediate precursors, collectively known as cervical intraepithelial neoplasia (CIN). Although primary prevention via prophylactic vaccination and secondary screening have significantly reduced incidence, cervical cancer remains a major global health burden, particularly in low- and middle-income countries. This comprehensive review evaluates the current landscape of HPV virology, pathogenesis, advanced diagnostic risk-stratification biomarkers, and evolving management paradigms.

Methods: This review synthesizes current literature regarding high-risk HPV types (predominantly HPV16 and 18), viral oncogene mechanisms (E6 and E7), multi-modal screening protocols, and therapeutic interventions ranging from standard surgical excisions to novel non-invasive modalities.

Results: While large loop excision of the transformation zone (LLETZ) remains the gold standard for high-grade CIN, its associated obstetric complications necessitate fertility-sparing alternatives. Recent advances highlight the efficacy of non-invasive modalities—including thermal ablation, photodynamic therapy (PDT), and topical immunomodulators such as imiquimod—which achieve high rates of lesion regression and viral clearance while preserving cervical structural integrity. Furthermore, diagnostic precision has been markedly improved through the integration of molecular markers (p16/Ki-67, DNA methylation signatures, and circulating microRNAs) and emerging microbiome-targeted adjunctive therapies.

Conclusions: The management of HPV-associated precancerous lesions is shifting from standardized surgical excision to a personalized, molecularly guided, and fertility-preserving paradigm. Future clinical efforts must focus on expanding global vaccine access while implementing multi-modal, minimally invasive therapeutic strategies.

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