CONTEMPORARY TREATMENT METHODS FOR DE QUERVAIN’S DISEASE: A SYSTEMATIC REVIEW
DOI:
https://doi.org/10.31435/ijitss.3(51).2026.6639Keywords:
De Quervain’s Disease, Conservative Treatment of De Quervain’s Disease, Corticosteroid Injections, Platelet-Rich Plasma, Surgical TreatmentAbstract
Introduction: De Quervain’s disease (DQD) is a tendinopathy involving the tendons of the abductor pollicis longus and extensor pollicis brevis muscles, leading to pain and limited function of the thumb and wrist. Therapeutic management aims to reduce pain, improve mobility, and restore hand function. The treatment methods used include corticosteroid and platelet-rich plasma (PRP) injections, as well as immobilization using a thumb spica splint. Rehabilitation also plays an important role and includes range-of-motion exercises, strengthening exercises, ultrasound therapy, and soft tissue mobilization. In cases where conservative treatment is ineffective, surgical treatment involving the release of the first extensor compartment may be considered.
Aim of the study: The aim of this study is to review the available literature on contemporary treatment methods for De Quervain’s disease and to present the current state of knowledge regarding their effectiveness. The study discusses the efficacy and safety of individual therapeutic methods, including corticosteroid and platelet-rich plasma injections, the use of orthoses, rehabilitation, and surgical treatment.
Methods and materials: A review of the literature available in the PubMed database was conducted using the following keywords: “De Quervain’s disease”; “De Quervain’s tenosynovitis”; “De Quervain’s tendinopathy”; “Conservative treatment of De Quervain’s disease”; “Corticosteroid injections”; “Platelet-rich plasma”; “Rehabilitation”; “Ultrasound therapy”; “Surgical treatment”.
Conclusion: De Quervain’s disease requires an individualized therapeutic approach, taking into account the severity of symptoms and the patient’s response to the treatment applied. Corticosteroid injections remain an effective first-line treatment, particularly when performed under ultrasound guidance. PRP may represent a safe alternative; however, further research is required. Orthoses and rehabilitation may support the treatment process, particularly in cases of mild symptoms. In patients with persistent symptoms despite conservative treatment, surgical treatment remains an effective option.
References
Fakoya, A. O., Tarzian, M., Sabater, E. L., Burgos, D. M., & Maldonado Marty, G. I. (2023). De Quervain's disease: A discourse on etiology, diagnosis, and treatment. Cureus, 15(4), e38079. https://doi.org/10.7759/cureus.38079
Shen, P. C., Wang, P. H., Wu, P. T., Wu, K. C., Hsieh, J. L., & Jou, I. M. (2015). The estrogen receptor-β expression in De Quervain's disease. International Journal of Molecular Sciences, 16(11), 26452–26462. https://doi.org/10.3390/ijms161125968
Ramchandani, J., Thakker, A., & Tharmaraja, T. (2022). Time to reconsider occupation induced De Quervain's tenosynovitis: An updated review of risk factors. Orthopedic Reviews, 14(4), 36911. https://doi.org/10.52965/001c.36911
Yurdakul, O. V., Aytüre, L., & Yalçinkaya, E. Y. (2017). Persistent de Quervain tenosynovitis induced by somatotropin treatment. Journal of Pediatric Endocrinology & Metabolism: JPEM, 30(11), 1223–1226. https://doi.org/10.1515/jpem-2017-0085
De Quervain in La Chaux-de-Fonds, F. (2005). On a form of chronic tendovaginitis. Journal of Hand Surgery, 30(4), 388–391. https://doi.org/10.1016/J.JHSB.2005.01.004
Goubau, J. F., Goubau, L., Van Tongel, A., Van Hoonacker, P., Kerckhove, D., & Berghs, B. (2014). The wrist hyperflexion and abduction of the thumb (WHAT) test: A more specific and sensitive test to diagnose de Quervain tenosynovitis than the Eichhoff's test. The Journal of Hand Surgery, European Volume, 39(3), 286–292. https://doi.org/10.1177/1753193412475043
Cavaleri, R., Schabrun, S. M., Te, M., & Chipchase, L. S. (2016). Hand therapy versus corticosteroid injections in the treatment of de Quervain's disease: A systematic review and meta-analysis. Journal of Hand Therapy: Official Journal of the American Society of Hand Therapists, 29(1), 3–11. https://doi.org/10.1016/j.jht.2015.10.004
Richie, C. A., 3rd, & Briner, W. W., Jr (2003). Corticosteroid injection for treatment of de Quervain's tenosynovitis: A pooled quantitative literature evaluation. The Journal of the American Board of Family Practice, 16(2), 102–106. https://doi.org/10.3122/jabfm.16.2.102
Harvey, F. J., Harvey, P. M., & Horsley, M. W. (1990). De Quervain's disease: Surgical or nonsurgical treatment. The Journal of Hand Surgery, 15(1), 83–87. https://doi.org/10.1016/s0363-5023(09)91110-8
Nguyen, M. L., & Jones, N. F. (2012). Rupture of both the abductor pollicis longus and extensor pollicis brevis tendons after steroid injection for de Quervain tenosynovitis. Plastic and Reconstructive Surgery, 129(5), 883e–886e. https://doi.org/10.1097/PRS.0b013e31824aa06d
Afridi, A., Ahmad, B., & Ahmed, H. (2024). Outcomes of single corticosteroid injection in De Quervain's tenosynovitis. Cureus, 16(10), e71928. https://doi.org/10.7759/cureus.71928
Peters-Veluthamaningal, C., van der Windt, D. A., Winters, J. C., & Meyboom-de Jong, B. (2009). Corticosteroid injection for de Quervain's tenosynovitis. The Cochrane Database of Systematic Reviews, 2009(3), CD005616. https://doi.org/10.1002/14651858.CD005616.pub2
Jirarattanaphochai, K., Saengnipanthkul, S., Vipulakorn, K., Jianmongkol, S., Chatuparisute, P., & Jung, S. (2004). Treatment of de Quervain disease with triamcinolone injection with or without nimesulide. A randomized, double-blind, placebo-controlled trial. The Journal of Bone and Joint Surgery. American Volume, 86(12), 2700–2706. https://doi.org/10.2106/00004623-200412000-00017
Bing, J. H., Choi, S. J., Jung, S. M., Ryu, D. S., Ahn, J. H., Kang, C. H., & Shin, D. R. (2018). Ultrasound-guided steroid injection for the treatment of de Quervain's disease: An anatomy-based approach. Skeletal Radiology, 47(11), 1483–1490. https://doi.org/10.1007/s00256-018-2958-9
McDermott, J. D., Ilyas, A. M., Nazarian, L. N., & Leinberry, C. F. (2012). Ultrasound-guided injections for de Quervain's tenosynovitis. Clinical Orthopaedics and Related Research, 470(7), 1925–1931. https://doi.org/10.1007/s11999-012-2369-5
Alam, M., Merza Abdulla Mohamed, A., Alawainati, M., & Haider, F. (2024). The use of platelet-rich plasma in De Quervain's tenosynovitis: A systematic review. Cureus, 16(11), e74232. https://doi.org/10.7759/cureus.74232
Chowley, P., Biswas, H., Mondal, K., Hazra, S., Hazra, S., & Das, P. (2025). Platelet-rich plasma versus corticosteroid injection for the treatment of de Quervain tenosynovitis: A randomised control open label equivalence trial. The Journal of Hand Surgery Asian-Pacific Volume, 30(2), 196–204. https://doi.org/10.1142/S2424835525500249
Hidajat, N. N., Magetsari, R. M. S. N., Steven, G., Budiman, J., & Prasetiyo, G. T. (2024). Platelet-rich plasma for de Quervain's tenosynovitis: A systematic review and meta-analysis. World Journal of Orthopedics, 15(9), 858–869. https://doi.org/10.5312/wjo.v15.i9.858
Goel, R., & Abzug, J. M. (2015). De Quervain's tenosynovitis: A review of the rehabilitative options. Hand (New York, N.Y.), 10(1), 1–5. https://doi.org/10.1007/s11552-014-9649-3
Lane, L. B., Boretz, R. S., & Stuchin, S. A. (2001). Treatment of de Quervain's disease: Role of conservative management. Journal of Hand Surgery (Edinburgh, Scotland), 26(3), 258–260. https://doi.org/10.1054/jhsb.2001.0568
Weiss, A. P., Akelman, E., & Tabatabai, M. (1994). Treatment of de Quervain's disease. The Journal of Hand Surgery, 19(4), 595–598. https://doi.org/10.1016/0363-5023(94)90262-3
Hartzell, T. L., Rubinstein, R., & Herman, M. (2012). Therapeutic modalities--an updated review for the hand surgeon. The Journal of Hand Surgery, 37(3), 597–621. https://doi.org/10.1016/j.jhsa.2011.12.042
Jaworski, C. A., Krause, M., & Brown, J. (2010). Rehabilitation of the wrist and hand following sports injury. Clinics in Sports Medicine, 29(1). https://doi.org/10.1016/j.csm.2009.09.007
Papa, J. A. (2012). Conservative management of De Quervain's stenosing tenosynovitis: A case report. The Journal of the Canadian Chiropractic Association, 56(2), 112–120.
Lee, H. J., Kim, P. T., Aminata, I. W., Hong, H. P., Yoon, J. P., & Jeon, I. H. (2014). Surgical release of the first extensor compartment for refractory de Quervain's tenosynovitis: Surgical findings and functional evaluation using DASH scores. Clinics in Orthopedic Surgery, 6(4), 405–409. https://doi.org/10.4055/cios.2014.6.4.405
Lee, Z. H., Stranix, J. T., Anzai, L., & Sharma, S. (2017). Surgical anatomy of the first extensor compartment: A systematic review and comparison of normal cadavers vs. De Quervain syndrome patients. Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS, 70(1), 127–131. https://doi.org/10.1016/j.bjps.2016.08.020
Bosman, R., Duraku, L. S., van der Oest, M. J. W., Hundepool, C. A., Rajaratnam, V., Power, D. M., Selles, R. W., & Zuidam, J. M. (2022). Surgical treatment outcome of de Quervain's disease: A systematic review and meta-analysis. Plastic and Reconstructive Surgery. Global Open, 10(5), e4305. https://doi.org/10.1097/GOX.0000000000004305
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