PHYSICAL ACTIVITY VS. LOW-GLYCEMIC-INDEX DIET: A COMPARATIVE ANALYSIS OF THEIR EFFECTS ON INSULIN RESISTANCE TREATMENT

Authors

DOI:

https://doi.org/10.31435/ijitss.3(51).2026.6684

Keywords:

Low Glycemic Index Diet, Physical Activity, Insulin Resistance, Lifestyle Modification

Abstract

Introduction Insulin resistance is a complex metabolic disorder that plays a pivotal role in the pathogenesis of type 2 diabetes, metabolic syndrome, and cardiovascular diseases. Given its increasing prevalence, growing attention is being directed toward non-pharmacological interventions such as low glycemic index (LGI) diets and regular physical activity. The objective of this study was to compare the effects of an LGI diet and physical activity on the management of insulin resistance.

Current State of Knowledge A review of scientific literature published between 2020 and 2025 was conducted using PubMed, Scopus, and Google Scholar databases. Both original research articles and review papers focusing on the impact of LGI diets and physical activity on insulin resistance were included. The findings indicate that both LGI diets and regular physical activity positively influence glycemic parameters by enhancing tissue sensitivity to insulin and reducing blood glucose and insulin concentrations. The combination of these interventions yields superior therapeutic outcomes compared to each intervention alone. The effectiveness of combined strategies also appears to be influenced by the timing and type of physical exercise.

Conclusions A multifaceted approach integrating an LGI diet with physical activity constitutes an effective strategy for managing insulin resistance. Given the multifactorial nature of insulin resistance, treatment should be individually tailored and monitored by healthcare professionals. Further research is warranted to account for variables such as sex, age, and duration of the intervention.

References

Martins, F. O., & Conde, S. V. (2022). Impact of diet composition on insulin resistance. Nutrients, 14(18), 3764. https://doi.org/10.3390/nu14183764

Marušić, M., Paić, M., Knobloch, M., & Liberati Pršo, A. M. (2021). NAFLD, insulin resistance, and diabetes mellitus type 2. Can J Gastroenterol Hepatol, 2021, 6613827. https://doi.org/10.1155/2021/6613827

Yu, Y. T., Fu, Y. H., Chen, Y. H., Fang, Y. W., & Tsai, M. H. (2025). Effect of dietary glycemic index on insulin resistance in adults without diabetes mellitus: A systematic review and meta-analysis. Front Nutr, 12, 1458353. https://doi.org/10.3389/fnut.2025.1458353

Lee, S. H., Park, S. Y., & Choi, C. S. (2022). Insulin resistance: From mechanisms to therapeutic strategies. Diabetes Metab J, 46(1), 15–37. https://doi.org/10.4093/dmj.2021.0280

Amaravadi, S. K., Maiya, G. A., K, V., & Shastry, B. A. (2024). Effectiveness of structured exercise program on insulin resistance and quality of life in type 2 diabetes mellitus–a randomized controlled trial. PLoS One, 19(5), e0302831. https://doi.org/10.1371/journal.pone.0302831

Praet, S. F., & van Loon, L. J. (2008). Exercise: The brittle cornerstone of type 2 diabetes treatment. Diabetologia, 51(3), 398–401. https://doi.org/10.1007/s00125-007-0910-y

American Diabetes Association. (2007). Standards of medical care in diabetes-2007. Diabetes Care, 30(Suppl 1), S4–S41.

Aneis, Y. M., El Refaye, G. E., Taha, M. M., Aldhahi, M. I., & Elsisi, H. F. (2023). Concurrent aerobic and strength training with caloric restriction reduces insulin resistance in obese premenopausal women: A randomized controlled trial. Medicina (Kaunas), 59(7), 1193. https://doi.org/10.3390/medicina59071193

Mauer, J., Chaurasia, B., Goldau, J., Vogt, M. C., Ruud, J., Nguyen, K. D., Theurich, S., Hausen, A. C., Schmitz, J., Bronneke, H. S., et al. (2014). Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin. Nat Immunol, 15, 423–430. https://doi.org/10.1038/ni.2865

de Mutsert, R., Gast, K., Widya, R., de Koning, E., Jazet, I., Lamb, H., le Cessie, S., de Roos, A., Smit, J., Rosendaal, F. J. M., et al. (2018). Associations of abdominal subcutaneous and visceral fat with insulin resistance and secretion differ between men and women: The Netherlands epidemiology of obesity study. Metab Syndr Relat Disord, 16, 54–63. https://doi.org/10.1089/met.2017.0128

Sigal, R. J., Kenny, G. P., Boulé, N. G., Wells, G. A., Prud’homme, D., Fortier, M., Reid, R. D., Tulloch, H., Coyle, D., Phillips, P., Jennings, A., & Jaffey, J. (2007). Effects of aerobic training, resistance training, or both on glycemic control in type 2 diabetes: A randomized trial. Ann Intern Med, 147(6), 357–369. https://doi.org/10.7326/0003-4819-147-6-200709180-00005

Burstein, R., Epstein, Y., Shapiro, Y., Charuzi, I., & Karnieli, E. (1990). Effect of an acute bout of exercise on glucose disposal in human obesity. J Appl Physiol, 69, 299–304. https://doi.org/10.1152/jappl.1990.69.1.299

Liu, A. G., Most, M. M., Brashear, M. M., Johnson, W. D., Cefalu, W. T., & Greenway, F. L. (2012). Reducing the glycemic index or carbohydrate content of mixed meals reduces postprandial glycemia and insulinemia over the entire day but does not affect satiety. Diabetes Care, 35(8), 1633–1637. https://doi.org/10.2337/dc12-0329

Brand-Miller, J., Hayne, S., Petocz, P., & Colagiuri, S. (2003). Low-glycemic index diets in the management of diabetes: A meta-analysis of randomized controlled trials. Diabetes Care, 26(8), 2261–2267. https://doi.org/10.2337/diacare.26.8.2261

Zafar, M. I., Mills, K. E., Zheng, J., Regmi, A., Hu, S. Q., Gou, L., & Chen, L. L. (2019). Low-glycemic index diets as an intervention for diabetes: A systematic review and meta-analysis. Am J Clin Nutr, 110(4), 891–902. https://doi.org/10.1093/ajcn/nqz149

Papakonstantinou, E., Oikonomou, C., Nychas, G., & Dimitriadis, G. D. (2022). Effects of diet, lifestyle, chrononutrition and alternative dietary interventions on postprandial glycemia and insulin resistance. Nutrients, 14(4), 823. https://doi.org/10.3390/nu14040823

Wadden, T. A., Tronieri, J. S., & Butryn, M. L. (2020). Lifestyle modification approaches for the treatment of obesity in adults. Am Psychol, 75(2), 235–251. https://doi.org/10.1037/amp0000517

O’Brien, M. J., Perez, A., Scanlan, A. B., Alos, V. A., Whitaker, R. C., Foster, G. D., et al. (2017). PREVENT-DM comparative effectiveness trial of lifestyle intervention and metformin. Am J Prev Med, 52(6), 788–797. https://doi.org/10.1016/j.amepre.2017.01.008

Johansen, M. Y., MacDonald, C. S., Hansen, K. B., Karstoft, K., Christensen, R., Pedersen, M., Hansen, L. S., Zacho, M., Wedell-Neergaard, A. S., Nielsen, S. T., Iepsen, U. W., Langberg, H., Vaag, A. A., Pedersen, B. K., & Ried-Larsen, M. (2017). Effect of an intensive lifestyle intervention on glycemic control in patients with type 2 diabetes: A randomized clinical trial. JAMA, 318(7), 637–646. https://doi.org/10.1001/jama.2017.10169

Slentz, C. A., Bateman, L. A., Willis, L. H., Granville, E. O., Piner, L. W., Samsa, G. P., Setji, T. L., Muehlbauer, M. J., Huffman, K. M., Bales, C. W., & Kraus, W. E. (2016). Effects of exercise training alone vs a combined exercise and nutritional lifestyle intervention on glucose homeostasis in prediabetic individuals: A randomised controlled trial. Diabetologia, 59(10), 2088–2096. https://doi.org/10.1007/s00125-016-4051-z

Corpeleijn, E., Saris, W. H. M., & Blaak, E. E. (2009). Metabolic flexibility in the development of insulin resistance and type 2 diabetes: Effects of lifestyle. Obes Rev, 10(2), 178–193. https://doi.org/10.1111/j.1467-789X.2008.00544.x

Savikj, M., Gabriel, B. M., Alm, P. S., Smith, J., Caidahl, K., Björnholm, M., Fritz, T., Krook, A., Zierath, J. R., & Wallberg-Henriksson, H. (2019). Afternoon exercise is more efficacious than morning exercise at improving blood glucose levels in individuals with type 2 diabetes: A randomised crossover trial. Diabetologia, 62(2), 233–237. https://doi.org/10.1007/s00125-018-4767-z

Aqeel, M., Forster, A., Richards, E. A., Hennessy, E., McGowan, B., Bhadra, A., Guo, J., Gelfand, S., Delp, E., & Eicher-Miller, H. A. (2020). The effect of timing of exercise and eating on postprandial response in adults: A systematic review. Nutrients, 12(1), 221. https://doi.org/10.3390/nu12010221

Dunkley, A. J., Charles, K., Gray, L. J., Camosso-Stefinovic, J., Davies, M. J., & Khunti, K. (2012). Effectiveness of interventions for reducing diabetes and cardiovascular disease risk in people with metabolic syndrome: Systematic review and mixed treatment comparison meta-analysis. Diabetes Obes Metab, 14(7), 616–625. https://doi.org/10.1111/j.1463-1326.2012.01571.x

Downloads

Published

2026-09-14

How to Cite

Ostrowicz, K., Brzuchacz, D., Malinowski, A., Pelczar, A., Oczkowska, W., Marchewka, K., Ciesielska, J., Furtek, D., Bartosik , K. ., & Borkowska, J. (2026). PHYSICAL ACTIVITY VS. LOW-GLYCEMIC-INDEX DIET: A COMPARATIVE ANALYSIS OF THEIR EFFECTS ON INSULIN RESISTANCE TREATMENT. International Journal of Innovative Technologies in Social Science, 3(3(51). https://doi.org/10.31435/ijitss.3(51).2026.6684