HONEY AND PROPOLIS IN PUBLIC HEALTH: EVIDENCE, REGULATION, AND TECHNOLOGY-ENABLED QUALITY ASSURANCE
DOI:
https://doi.org/10.31435/ijitss.1(49).2026.5288Keywords:
Honey, Propolis, Apitherapy, Public Health, Quality Assurance, Digital TraceabilityAbstract
Bee-derived products such as honey and propolis are increasingly used as foods, supplements, and components of traditional and complementary medicine. At the same time, public health systems face antibiotic overuse, a rising burden of chronic diseases, and an expanding market of natural products whose quality, safety, and claims are variable. This review synthesizes recent peer-reviewed evidence on honey- and propolis-based products with an emphasis on (i) clinically and socially relevant application areas, (ii) public health determinants of safe use (knowledge, regulation, and information pathways), and (iii) modern technologies that can improve standardization, authentication, and consumer protection. A targeted narrative review was conducted using PubMed, PMC, and Google Scholar, prioritizing recent reviews, clinical and preclinical studies, and analytical quality-control research. The literature suggests the strongest and most mature evidence base for symptom relief in selected pediatric respiratory infections, alongside emerging but heterogeneous findings in chronic disease contexts (e.g., metabolic and kidney-disease populations). Across indications, major translation barriers include variability in botanical origin and composition, inconsistent preparations and dosing, contamination and adulteration risks, and uneven professional guidance. Survey data indicate important knowledge gaps among healthcare professionals and highlight social media as a dominant information source, raising concerns about misinformation-driven use. Advances in chemical analytics (spectroscopy, chromatography-mass spectrometry), DNA-based botanical verification, and non-thermal decontamination approaches can strengthen quality assurance. Integrating these technologies with clearer governance and health-professional education may help translate honey and propolis into responsible, evidence-aligned public health practices.
References
Anjos, O., & Miguel, M. G. (2025). Unveiling the chemistry and bioactivity of bee products and their derivatives. Foods, 14(17), 3058. https://doi.org/10.3390/foods14173058
Bertoni, C., Alberti, I., Parri, N., Agostoni, C. V., Bettocchi, S., Zampogna, S., & Milani, G. P. (2025). Phytotherapeutic, homeopathic interventions and bee products for pediatric infections: A scoping review. Nutrients, 17(19), 3137. https://doi.org/10.3390/nu17193137
Gökkaya, İ., Renda, G., Ayhan, F., & Yazici, N. (2025). Awareness of apitherapy: A study of healthcare professionals in Türkiye. Journal of Pharmacopuncture, 28(1), 35–46. https://doi.org/10.3831/KPI.2025.28.1.35
Jagua-Gualdrón, A., García-Reyes, N. A., & Fernández-Bernal, R. E. (2025). Apitherapy for diabetes mellitus: Mechanisms and clinical implications. Journal of Complementary and Integrative Medicine, 22(2), 228–236. https://doi.org/10.1515/jcim-2024-0367
Karagözoğlu, F., Şahin, E., Melek, Ş., Şahin, S. B., Koca, R. H., Yüksel, H., & Güngören, A. (2025). Effects of apilarnil on type 2 diabetes-induced IRS-1/PI3K/Akt mediated insulin resistance in male rats. ACS Omega, 10(23), 25027–25038. https://doi.org/10.1021/acsomega.5c02662
Kemp, J. A., Mendonça, M., Chrispim, P., Ribeiro, M., Britto, I., Coutinho-Wolino, K. S., Ribeiro-Alves, M., Nakao, L. S., Kussi, F., Coelho, E. B., Berretta, A. A., Mafra, D., & Cardozo, L. (2025). Apitherapy with royal jelly and green propolis EPP-AF improves cardiovascular risk markers in patients undergoing hemodialysis: A randomized double-blind placebo-controlled trial. Toxins, 17(8), 369. https://doi.org/10.3390/toxins17080369
Li, D., Wu, Y., Chang, L., Song, Y., Du, X., Xue, F., Liu, Y., Wu, J., & Wang, T. (2025). Therapeutic effects of melittin on paclitaxel-induced peripheral neuropathic pain and spinal neuronal hyperactivity in male rats. Frontiers in Neuroscience, 19, 1622553. https://doi.org/10.3389/fnins.2025.1622553
Matias, K. V., Gonçalves, V. de C., & Scorza, F. A. (2025). Nature’s remedies: Exploring the potential of propolis to alleviate non-motor manifestations of Parkinson’s disease. Molecules, 30(8), 1672. https://doi.org/10.3390/molecules30081672
Rezazadeh, A., Mehrabian, A. R., Maleki, H., Shakoori, Z., Zarei Golbaghi, N., Sharifi, T., Yazdi, H., & Zarqami Amirsalari, M. (2025). Evaluation of bee pollen by characterizing its botanical origin, total phenolic content, and microbial load for the formulation of apitherapy products. PLOS ONE, 20(9), e0327480. https://doi.org/10.1371/journal.pone.0327480
Sanlier, N., Yildiz Kaya, E., & Yucel, I. I. (2026). Health effects of bee products: A comprehensive review. Food Science & Nutrition, 14(2), e71165. https://doi.org/10.1002/fsn3.71165
Solanki, P., Rana, M., Choudhary, K. S., Ahuja, V., Kumar, V., & Tyagi, A. (2025). The anti-leukemic potential of bee venom. International Journal of General Medicine, 18, 7395–7408. https://doi.org/10.2147/IJGM.S560153
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Copyright (c) 2026 Daria Danielczyk, Michał Babicz, Kamil Chudzicki, Wiktor Czyżewski, Katarzyna Rosa, Agata Słoma, Anna Szot, Dominik Szydełko, Martyna Szymczyk, Paweł Żurek

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