POLISH AND AMERICAN GUIDELINES FOR VITAMIN D DEFICIENCY PREVENTION AND TREATMENT FOR THE GENERAL POPULATION - A LITERATURE REVIEW
DOI:
https://doi.org/10.31435/ijitss.2(50).2026.5661Keywords:
Vitamin D, Guidelines, Recommendations, Supplementation, TreatmentAbstract
Vitamin D plays a well-known role in calcium and phosphate homeostasis. Recent findings also indicate many extraskeletal effects. Studies have shown that a vitamin D deficiency has been associated with chronic conditions in musculoskeletal, cardiovascular, neurological and immune systems. There have been multiple national and international guidelines considering the problem of vitamin D supplementation and treatment. Recommendations for vitamin D prophylaxis and treatment show variability which may result in confusion in clinical practice. The aim of this review is to compare diagnostic thresholds of scrum 25(OH)D levels and dosing strategies for prevention and treatment between selected vitamin D guidelines published in Poland, Central Europe and the United States of America. Future recommendations should integrate the results of observational studies and randomized control trials. This way they may benefit the clinicians and patients by simplifying treatment decisions and improving clinical outcomes.
References
Aberger, S., Schreiber, N., Pilz, S., Eller, K., Rosenkranz, A. R., & Kirsch, A. H. (2024). Targeting calcitriol metabolism in acute vitamin D toxicity: A comprehensive review and clinical insight. International Journal of Molecular Sciences, 25(18), Article 10003. https://doi.org/10.3390/ijms251810003
Pludowski, P., Takacs, I., Boyanov, M., Belaya, Z., Diaconu, C. C., Mokhort, T., Zherdova, N., Rasa, I., Payer, J., & Pilz, S. (2022). Clinical practice in the prevention, diagnosis and treatment of vitamin D deficiency: A Central and Eastern European expert consensus statement. Nutrients, 14(7), Article 1483. https://doi.org/10.3390/nu14071483
Aberger, S., Schreiber, N., Pilz, S., Eller, K., Rosenkranz, A. R., & Kirsch, A. H. (2024). Targeting calcitriol metabolism in acute vitamin D toxicity: A comprehensive review and clinical insight. International Journal of Molecular Sciences, 25(18), Article 10003. https://doi.org/10.3390/ijms251810003
Asif, A., & Farooq, N. (2023). Vitamin D toxicity. In StatPearls. StatPearls Publishing.
Janoušek, J., Pilařová, V., Macáková, K., Nomura, A., Veiga-Matos, J., Silva, D. D. D., Remião, F., Saso, L., Malá-Ládová, K., Malý, J., Nováková, L., & Mladěnka, P. (2022). Vitamin D: Sources, physiological role, biokinetics, deficiency, therapeutic use, toxicity, and overview of analytical methods for detection of vitamin D and its metabolites. Critical Reviews in Clinical Laboratory Sciences, 59(8), 517–554. https://doi.org/10.1080/10408363.2022.2070595
Cui, A., Zhang, T., Xiao, P., Fan, Z., Wang, H., & Zhuang, Y. (2023). Global and regional prevalence of vitamin D deficiency in population-based studies from 2000 to 2022: A pooled analysis of 7.9 million participants. Frontiers in Nutrition, 10, Article 1070808. https://doi.org/10.3389/fnut.2023.1070808
Bopape, P. G., Wagenaar, C., Poka, M., & Bronkhorst, E. (2023). Vitamin D supplementation in a post-pandemic era: A narrative review. South African Family Practice, 65(1), Article e1–e6. https://doi.org/10.4102/safp.v65i1.5752
Charzewska, J., Chlebna-Sokół, D., Chybicka, A., Czech-Kowalska, J., Dobrzańska, A., Helwich, E., Imiela, J. R., Karczmarewicz, E., Ksiazyk, J. B., Lewiński, A., Lorenc, R. S., Lukas, W., Łukaszkiewicz, J., Marcinowska-Suchowierska, E., Milanowski, A., Milewicz, A., Płudowski, P., Pronicka, E., Radowicki, S., Ryzko, J., … Zespół Ekspertów. (2010). Stanowisko Zespołu Ekspertów. Polskie zalecenia dotyczace profilaktyki niedoborów witaminy D—2009 [Prophylaxis of vitamin D deficiency—Polish recommendation 2009]. Ginekologia Polska, 81(2), 149–153.
Holick, M. F., Binkley, N. C., Bischoff-Ferrari, H. A., Gordon, C. M., Hanley, D. A., Heaney, R. P., Murad, M. H., Weaver, C. M., & Endocrine Society. (2011). Evaluation, treatment, and prevention of vitamin D deficiency: An Endocrine Society clinical practice guideline. The Journal of Clinical Endocrinology & Metabolism, 96(7), 1911–1930. https://doi.org/10.1210/jc.2011-0385
Płudowski, P., Karczmarewicz, E., Bayer, M., Carter, G., Chlebna-Sokół, D., Czech-Kowalska, J., Dębski, R., Decsi, T., Dobrzańska, A., Franek, E., Głuszko, P., Grant, W. B., Holick, M. F., Yankovskaya, L., Konstantynowicz, J., Książyk, J. B., Księżopolska-Orłowska, K., Lewiński, A., Litwin, M., Lohner, S., … Żmijewski, M. A. (2013). Practical guidelines for the supplementation of vitamin D and the treatment of deficits in Central Europe: Recommended vitamin D intakes in the general population and groups at risk of vitamin D deficiency. Endokrynologia Polska, 64(4), 319–327. https://doi.org/10.5603/ep.2013.0012
Rusińska, A., Płudowski, P., Walczak, M., Borszewska-Kornacka, M. K., Bossowski, A., Chlebna-Sokół, D., Czech-Kowalska, J., Dobrzańska, A., Franek, E., Helwich, E., Jackowska, T., Kalina, M. A., Konstantynowicz, J., Książyk, J., Lewiński, A., Łukaszkiewicz, J., Marcinowska-Suchowierska, E., Mazur, A., Michałus, I., Peregud-Pogorzelski, J., … Zygmunt, A. (2018). Vitamin D supplementation guidelines for general population and groups at risk of vitamin D deficiency in Poland: Recommendations of the Polish Society of Pediatric Endocrinology and Diabetes and the expert panel with participation of national specialist consultants and representatives of scientific societies—2018 update. Frontiers in Endocrinology, 9, Article 246. https://doi.org/10.3389/fendo.2018.00246
Płudowski, P., Kos-Kudła, B., Walczak, M., Fal, A., Zozulińska-Ziółkiewicz, D., Sieroszewski, P., Peregud-Pogorzelski, J., Lauterbach, R., Targowski, T., Lewiński, A., Spaczyński, R., Wielgoś, M., Pinkas, J., Jackowska, T., Helwich, E., Mazur, A., Ruchała, M., Zygmunt, A., Szalecki, M., Bossowski, A., … Misiorowski, W. (2023). Guidelines for preventing and treating vitamin D deficiency: A 2023 update in Poland. Nutrients, 15(3), Article 695. https://doi.org/10.3390/nu15030695
Demay, M. B., Pittas, A. G., Bikle, D. D., Diab, D. L., Kiely, M. E., Lazaretti-Castro, M., Lips, P., Mitchell, D. M., Murad, M. H., Powers, S., Rao, S. D., Scragg, R., Tayek, J. A., Valent, A. M., Walsh, J. M. E., & McCartney, C. R. (2024). Vitamin D for the prevention of disease: An Endocrine Society clinical practice guideline. The Journal of Clinical Endocrinology & Metabolism, 109(8), 1907–1947. https://doi.org/10.1210/clinem/dgae290
National Institutes of Health, Office of Dietary Supplements. (n.d.). Vitamin D fact sheet for health professionals. https://ods.od.nih.gov/factsheets/VitaminDHealthProfessional/
Pludowski, P., Marcinowska-Suchowierska, E., Togizbayev, G., Belaya, Z., Grant, W. B., Pilz, S., & Holick, M. F. (2024). Daily and weekly “high doses” of cholecalciferol for the prevention and treatment of vitamin D deficiency for obese or multi-morbidity and multi-treatment patients requiring multi-drugs: A narrative review. Nutrients, 16(15), Article 2541. https://doi.org/10.3390/nu16152541
Holick, M. F. (2024). Revisiting vitamin D guidelines: A critical appraisal of the literature. Endocrine Practice, 30(12), 1227–1241. https://doi.org/10.1016/j.eprac.2024.10.011
Wimalawansa, S. J., Weiss, S. T., & Hollis, B. W. (2024). Integrating endocrine, genomic, and extra-skeletal benefits of vitamin D into national and regional clinical guidelines. Nutrients, 16(22), Article 3969. https://doi.org/10.3390/nu16223969
Grant, W. B., Wimalawansa, S. J., Pludowski, P., & Cheng, R. Z. (2025). Vitamin D: Evidence-based health benefits and recommendations for population guidelines. Nutrients, 17(2), Article 277. https://doi.org/10.3390/nu17020277
Wimalawansa, S. J. (2018). Non-musculoskeletal benefits of vitamin D. The Journal of Steroid Biochemistry and Molecular Biology, 175, 60–81. https://doi.org/10.1016/j.jsbmb.2016.09.016
Wimalawansa, S. J. (2024). Physiology of vitamin D: Focusing on disease prevention. Nutrients, 16(11), Article 1666. https://doi.org/10.3390/nu16111666
Giustina, A., Bilezikian, J. P., Adler, R. A., Banfi, G., Bikle, D. D., Binkley, N. C., Bollerslev, J., Bouillon, R., Brandi, M. L., Casanueva, F. F., di Filippo, L., Donini, L. M., Ebeling, P. R., Fuleihan, G. E., Fassio, A., Frara, S., Jones, G., Marcocci, C., Martineau, A. R., Minisola, S., … Virtanen, J. K. (2024). Consensus statement on vitamin D status assessment and supplementation: Whys, whens, and hows. Endocrine Reviews, 45(5), 625–654. https://doi.org/10.1210/endrev/bnae009
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Copyright (c) 2026 Zuzanna Rybka, Alicja Maciejewska, Maja Kaczor, Monika Stępińska, Marta Omiecińska, Weronika Trynkiewicz, Emilia Lenkiewicz, Karolina Dąbrowska, Jakub Winiarczyk, Maja Śmigielska

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