TAURINE, BRANCHED-CHAIN AMINO ACIDS, AND BETA-ALANINE: AN EVALUATION OF THEIR EFFICACY AND APPLICATIONS IN SPORTS AND MEDICAL CONDITIONS. A REVIEW ARTICLE

Authors

DOI:

https://doi.org/10.31435/ijitss.3(51).2026.6024

Keywords:

Taurine, Branched-Chain Amino Acids (BCAAs), Beta-Alanine, Sport Performance

Abstract

In recent years, the use of dietary supplements has increased substantially, both among professional athletes and individuals engaging in physical activity for recreational purposes. The aim of this study was to critically review the literature available in the PubMed database regarding the efficacy of taurine, beta-alanine, and branched-chain amino acid (BCAAs) supplementation in enhancing athletic performance, as well as their potential applications beyond sport, including in selected medical conditions. Analysis of the available evidence demonstrates that each of these compounds exerts distinct physiological effects and mechanisms of action. Taurine, due to its antioxidant properties and ability to modulate the inflammatory response, may support recovery processes and reduce the concentration of biomarkers associated with skeletal muscle damage. Beta-alanine, by enhancing intracellular hydrogen ion buffering capacity, appears to improve performance during high-intensity physical activity. In contrast, findings related to BCAA supplementation remain inconclusive. Although BCAAs may exhibit anabolic potential and contribute to reduction in post-exercise muscle soreness, current evidence does not demonstrate a consistent or significant effect on muscle strength or overall physical performance.

Interpretation of available data is limited by considerable heterogeneity across studies, including small sample sizes, and the variability in supplementation protocols. Therefore, further studies with high methodological rigor are required to establish definitive conclusions regarding the efficacy and clinical relevance of these supplements.

References

Areces, F., Salinero, J. J., Abian-Vicen, J., González-Millán, C., Gallo-Salazar, C., Ruiz-Vicente, D., Lara, B., & Del Coso, J. (2014). A 7-day oral supplementation with branched-chain amino acids was ineffective to prevent muscle damage during a marathon. Amino Acids, 46(5), 1169–1176. https://doi.org/10.1007/s00726-014-1677-3

Bai, G.-H., Tsai, M.-C., Tsai, H.-W., Chang, C.-C., & Hou, W.-H. (2022). Effects of branched-chain amino acid-rich supplementation on EWGSOP2 criteria for sarcopenia in older adults: A systematic review and meta-analysis. European Journal of Nutrition, 61(2), 637–651. https://doi.org/10.1007/s00394-021-02710-0

Baliou, S., Adamaki, M., Ioannou, P., Pappa, A., Panayiotidis, M., Spandidos, D., Christodoulou, I., Kyriakopoulos, A., & Zoumpourlis, V. (2021). Protective role of taurine against oxidative stress (review). Molecular Medicine Reports, 24(2), 605. https://doi.org/10.3892/mmr.2021.12242

Berezhnoy, D. S., Stvolinsky, S. L., Lopachev, A. V., Devyatov, A. A., Lopacheva, O. M., Kulikova, O. I., Abaimov, D. A., & Fedorova, T. N. (2019). Carnosine as an effective neuroprotector in brain pathology and potential neuromodulator in normal conditions. Amino Acids, 51(1), 139–150. https://doi.org/10.1007/s00726-018-2667-7

Harris, R. C., Dunnett, M., & Greenhaff, P. L. (1998). Carnosine and taurine contents in individual fibres of human vastus lateralis muscle. Journal of Sports Sciences, 16(7), 639–643. https://doi.org/10.1080/026404198366443

Cairns, S. P., & Lindinger, M. I. (2025). Lactic acidosis: Implications for human exercise performance. European Journal of Applied Physiology, 125(7), 1761–1795. https://doi.org/10.1007/s00421-025-05750-0

Cimadevilla-Fernández-Pola, E., Martínez-Roldán, C., Maté-Muñoz, J. L., Guodemar-Pérez, J., Sánchez-Calabuig, M. A., García-Fernández, P., Hervás-Pérez, J. P., & Hernández-Lougedo, J. (2024). Effects of β-alanine supplementation on subjects performing high-intensity functional training. Nutrients, 16(14), 2340. https://doi.org/10.3390/nu16142340

Colosimo, S., Bertoli, S., & Saffioti, F. (2023). Use of branched-chain amino acids as a potential treatment for improving nutrition-related outcomes in advanced chronic liver disease. Nutrients, 15(19), 4190. https://doi.org/10.3390/nu15194190

da Silva, L. A., Tromm, C. B., Bom, K. F., Mariano, I., Pozzi, B., da Rosa, G. L., Tuon, T., da Luz, G., Vuolo, F., Petronilho, F., Cassiano, W., De Souza, C. T., & Pinho, R. A. (2014). Effects of taurine supplementation following eccentric exercise in young adults. Applied Physiology, Nutrition, and Metabolism, 39(1), 101–104. https://doi.org/10.1139/apnm-2012-0229

Davis, C. K., Laud, P. J., Bahor, Z., Rajanikant, G., & Majid, A. (2016). Systematic review and stratified meta-analysis of the efficacy of carnosine in animal models of ischemic stroke. Journal of Cerebral Blood Flow & Metabolism, 36(10), 1686–1694. https://doi.org/10.1177/0271678X16658302

De Carvalho, F. G., Barbieri, R. A., Carvalho, M. B., Dato, C. C., Campos, E. Z., Gobbi, R. B., Papoti, M., Silva, A. S. R., & de Freitas, E. C. (2018). Taurine supplementation can increase lipolysis and affect the contribution of energy systems during front crawl maximal effort. Amino Acids, 50(1), 189–198. https://doi.org/10.1007/s00726-017-2505-3

de Aguiar Vallim, T. Q., Tarling, E. J., & Edwards, P. A. (2013). Pleiotropic roles of bile acids in metabolism. Cell Metabolism, 17(5), 657–669. https://doi.org/10.1016/j.cmet.2013.03.013

Deng, H., Song, T., Yin, M., Xu, K., Zhong, Y., Liu, P., Sun, S., Bin Naharudin, M. N., Yusof, A., & Fan, X. (2025). Does one shot work? The acute impact of a single taurine dose on exercise performance: A meta‐analytic review. Scandinavian Journal of Medicine & Science in Sports, 35(9). https://doi.org/10.1111/sms.70123

Douligeris, A., Methenitis, S., Stavropoulos-Kalinoglou, A., Panayiotou, G., Vogazianos, P., Lazou, A., Feidantsis, K., Giaginis, C., Papanikolaou, K., Arnaoutis, G., Manios, Y., Jamurtas, A. Z., & Papadopoulou, S. K. (2024). Effects of four weeks of in-season pre-workout supplementation on performance, body composition, muscle damage, and health-related markers in basketball players: A randomized controlled study. Journal of Functional Morphology and Kinesiology, 9(2). https://doi.org/10.3390/jfmk9020085

Foos, T. M., & Wu, J.-Y. (2002). The role of taurine in the central nervous system and the modulation of intracellular calcium homeostasis. Neurochemical Research, 27(1–2), 21–26. https://doi.org/10.1023/A:1014890219513

Gallo-Salazar, C., Areces, F., Abián-Vicén, J., Lara, B., Salinero, J. J., Gonzalez-Millán, C., Portillo, J., Muñoz, V., Juarez, D., & Coso, J. Del. (2015). Enhancing physical performance in elite junior tennis players with a caffeinated energy drink. International Journal of Sports Physiology and Performance, 10(3), 305–310. https://doi.org/10.1123/ijspp.2014-0103

Gluud, L. L., Dam, G., Les, I., Marchesini, G., Borre, M., Aagaard, N. K., & Vilstrup, H. (2017). Branched-chain amino acids for people with hepatic encephalopathy. Cochrane Database of Systematic Reviews, 2020(3). https://doi.org/10.1002/14651858.CD001939.pub4

Harris, R. C., Tallon, M. J., Dunnett, M., Boobis, L., Coakley, J., Kim, H. J., Fallowfield, J. L., Hill, C. A., Sale, C., & Wise, J. A. (2006). The absorption of orally supplied beta-alanine and its effect on muscle carnosine synthesis in human vastus lateralis. Amino Acids, 30(3), 279–289. https://doi.org/10.1007/s00726-006-0299-9

Hoffman, J. R., Varanoske, A., & Stout, J. R. (2018). Effects of β-alanine supplementation on carnosine elevation and physiological performance (pp. 183–206). https://doi.org/10.1016/bs.afnr.2017.12.003

Huxtable, R. J. (1992). Physiological actions of taurine. Physiological Reviews, 72(1), 101–163. https://doi.org/10.1152/physrev.1992.72.1.101

Kalbe, C., Metzger, K., Gariépy, C., & Palin, M.-F. (2023). Effect of muscle fibre types and carnosine levels on the expression of carnosine-related genes in pig skeletal muscle. Histochemistry and Cell Biology, 160(1), 63–77. https://doi.org/10.1007/s00418-023-02193-6

Kaur, A., Yousuf, H., Ramgobin-Marshall, D., Jain, R., & Jain, R. (2022). Energy drink consumption: A rising public health issue. Reviews in Cardiovascular Medicine, 23(3). https://doi.org/10.31083/j.rcm2303083

Kawahara, M., Tanaka, K., & Kato-Negishi, M. (2018). Zinc, carnosine, and neurodegenerative diseases. Nutrients, 10(2), 147. https://doi.org/10.3390/nu10020147

Kephart, W. C., Wachs, T. D., Mac Thompson, R., Brooks Mobley, C., Fox, C. D., McDonald, J. R., Ferguson, B. S., Young, K. C., Nie, B., Martin, J. S., Company, J. M., Pascoe, D. D., Arnold, R. D., Moon, J. R., & Roberts, M. D. (2016). Ten weeks of branched-chain amino acid supplementation improves select performance and immunological variables in trained cyclists. Amino Acids, 48(3), 779–789. https://doi.org/10.1007/s00726-015-2125-8

Laidlaw, S., Grosvenor, M., & Kopple, J. (1990). The taurine content of common foodstuffs. Journal of Parenteral and Enteral Nutrition, 14(2), 183–188. https://doi.org/10.1177/0148607190014002183

Lara, B., Ruiz-Vicente, D., Areces, F., Abián-Vicén, J., Salinero, J. J., Gonzalez-Millán, C., Gallo-Salazar, C., & Del Coso, J. (2015). Acute consumption of a caffeinated energy drink enhances aspects of performance in sprint swimmers. British Journal of Nutrition, 114(6), 908–914. https://doi.org/10.1017/S0007114515002573

Lien, Y. H., Shapiro, J. I., & Chan, L. (1990). Effects of hypernatremia on organic brain osmoles. Journal of Clinical Investigation, 85(5), 1427–1435. https://doi.org/10.1172/JCI114587

Mangner, N., Linke, A., Oberbach, A., Kullnick, Y., Gielen, S., Sandri, M., Hoellriegel, R., Matsumoto, Y., Schuler, G., & Adams, V. (2013). Exercise training prevents TNF-α induced loss of force in the diaphragm of mice. PLoS ONE, 8(1), e52274. https://doi.org/10.1371/journal.pone.0052274

Manzi, P., & Pizzoferrato, L. (2013). Taurine in milk and yoghurt marketed in italy. International Journal of Food Sciences and Nutrition, 64(1), 112–116. https://doi.org/10.3109/09637486.2012.704906

Nemet, D., Wolach, B., & Eliakim, A. (2005). Proteins and amino acid supplementation in sports: are they truly necessary? The Israel Medical Association Journal : IMAJ, 7(5), 328–332.

Nie, Z., Liu, Y., Zhang, M., Wu, C., Cao, Q., Xu, J., Zheng, Y., Min, Z., Zhang, W., & Han, S. (2025). Effects of oral taurine supplementation on cardiometabolic risk factors: A meta-analysis and systematic review of randomized clinical trials. Nutrition Reviews. https://doi.org/10.1093/nutrit/nuaf220

Quinlivan, A., Irwin, C., Grant, G. D., Anoopkumar-Dukie, S., Skinner, T., Leveritt, M., & Desbrow, B. (2015). The effects of Red Bull energy drink compared with caffeine on cycling time-trial performance. International Journal of Sports Physiology and Performance, 10(7), 897–901. https://doi.org/10.1123/ijspp.2014-0481

Ra, S.-G., Akazawa, N., Choi, Y., Matsubara, T., Oikawa, S., Kumagai, H., Tanahashi, K., Ohmori, H., & Maeda, S. (2015). Taurine supplementation reduces eccentric exercise-induced delayed onset muscle soreness in young men (pp. 765–772). https://doi.org/10.1007/978-3-319-15126-7_61

Ra, S.-G., Miyazaki, T., Ishikura, K., Nagayama, H., Komine, S., Nakata, Y., Maeda, S., Matsuzaki, Y., & Ohmori, H. (2013). Combined effect of branched-chain amino acids and taurine supplementation on delayed onset muscle soreness and muscle damage in high-intensity eccentric exercise. Journal of the International Society of Sports Nutrition, 10(1), 51. https://doi.org/10.1186/1550-2783-10-51

Salem, A., Ben Maaoui, K., Jahrami, H., AlMarzooqi, M. A., Boukhris, O., Messai, B., Clark, C. C. T., Glenn, J. M., Ghazzaoui, H. A., Bragazzi, N. L., Ammar, A., Trabelsi, K., & Chtourou, H. (2024). Attenuating muscle damage biomarkers and muscle soreness after an exercise-induced muscle damage with branched-chain amino acid (BCAA) supplementation: A systematic review and meta-analysis with meta-regression. Sports Medicine - Open, 10(1), 42. https://doi.org/10.1186/s40798-024-00686-9

Santulli, G., Kansakar, U., Varzideh, F., Mone, P., Jankauskas, S. S., & Lombardi, A. (2023). Functional role of taurine in aging and cardiovascular health: An updated overview. Nutrients, 15(19), 4236. https://doi.org/10.3390/nu15194236

Saunders, B., Elliott-Sale, K., Artioli, G. G., Swinton, P. A., Dolan, E., Roschel, H., Sale, C., & Gualano, B. (2017). Β-alanine supplementation to improve exercise capacity and performance: A systematic review and meta-analysis. British Journal of Sports Medicine, 51(8), 658–669. https://doi.org/10.1136/bjsports-2016-096396

Schaffer, S. W., Shimada-Takaura, K., Jong, C. J., Ito, T., & Takahashi, K. (2016). Impaired energy metabolism of the taurine-deficient heart. Amino Acids, 48(2), 549–558. https://doi.org/10.1007/s00726-015-2110-2

Smith, J. W., Krings, B. M., Shepherd, B. D., Waldman, H. S., Basham, S. A., & McAllister, M. J. (2018). Effects of carbohydrate and branched-chain amino acid beverage ingestion during acute upper body resistance exercise on performance and postexercise hormone response. Applied Physiology, Nutrition, and Metabolism, 43(5), 504–509. https://doi.org/10.1139/apnm-2017-0563

Song, P., Zhang, X., Wang, S., Xu, W., & Wei, F. (2023). Advances in the synthesis of β-alanine. Frontiers in Bioengineering and Biotechnology, 11. https://doi.org/10.3389/fbioe.2023.1283129

Sun, Q., Wang, J., Wang, H., Yu, H., Wan, K., Ma, F., & Wang, R. (2024). Effect of long-term taurine supplementation on the lipid and glycaemic profile in adults with overweight or obesity: A systematic review and meta-analysis. Nutrients, 17(1), 55. https://doi.org/10.3390/nu17010055

Trexler, E. T., Smith-Ryan, A. E., Stout, J. R., Hoffman, J. R., Wilborn, C. D., Sale, C., Kreider, R. B., Jäger, R., Earnest, C. P., Bannock, L., Campbell, B., Kalman, D., Ziegenfuss, T. N., & Antonio, J. (2015). International society of sports nutrition position stand: Beta-alanine. Journal of the International Society of Sports Nutrition, 12, 30. https://doi.org/10.1186/s12970-015-0090-y

Verner, A., Craig, S., & McGuire, W. (2007). Effect of taurine supplementation on growth and development in preterm or low birth weight infants. The Cochrane Database of Systematic Reviews, 2007(4), CD006072. https://doi.org/10.1002/14651858.CD006072.pub2

Virgiliou, C., Theodoridis, G., Wilson, I. D., & Gika, H. G. (2021). Quantification of endogenous aminoacids and aminoacid derivatives in urine by hydrophilic interaction liquid chromatography tandem mass spectrometry. Journal of Chromatography A, 1642, 462005. https://doi.org/10.1016/j.chroma.2021.462005

Ward, R., Bridge, C. A., McNaughton, L. R., & Sparks, S. A. (2016). The effect of acute taurine ingestion on 4-km time trial performance in trained cyclists. Amino Acids, 48(11), 2581–2587. https://doi.org/10.1007/s00726-016-2282-4

Wolfson, R. L., Chantranupong, L., Saxton, R. A., Shen, K., Scaria, S. M., Cantor, J. R., & Sabatini, D. M. (2016). Sestrin2 is a leucine sensor for the mTORC1 pathway. Science, 351(6268), 43–48. https://doi.org/10.1126/science.aab2674

Wolfson, R. L., & Sabatini, D. M. (2017). The dawn of the age of amino acid sensors for the mTORC1 pathway. Cell Metabolism, 26(2), 301–309. https://doi.org/10.1016/j.cmet.2017.07.001

Zhang, X., Song, L., Cheng, X., Yang, Y., Luan, B., Jia, L., Xu, F., & Zhang, Z. (2011). Carnosine pretreatment protects against hypoxia–ischemia brain damage in the neonatal rat model. European Journal of Pharmacology, 667(1–3), 202–207. https://doi.org/10.1016/j.ejphar.2011.06.003

Downloads

Published

2026-09-17

How to Cite

Jasińska, J., Iskrzyński, D., Bułat, A., Gródek, A., Iglantowicz, J., Sanakiewicz, S., Obajtek, P., Dubiel, W., & Dubiel, M. (2026). TAURINE, BRANCHED-CHAIN AMINO ACIDS, AND BETA-ALANINE: AN EVALUATION OF THEIR EFFICACY AND APPLICATIONS IN SPORTS AND MEDICAL CONDITIONS. A REVIEW ARTICLE. International Journal of Innovative Technologies in Social Science, 4(3(51). https://doi.org/10.31435/ijitss.3(51).2026.6024

Most read articles by the same author(s)

1 2 > >>